Hemiparkinsonism in monkeys after unilateral caudate nucleus infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior and histology

Brain Research

Volumn 474, Issue 2, 1988, Pages 327-332

  Imai, Hisamasa ^a   Nakamura, Toshiki ^a   Endo, Kiyonori ^a   Narabayashi, Hirotaro ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; 1 Methyl 4 phenylpyridinium ion; Caudate nucleus; Dopamine; Hemiparkinsonism; Monkey; Osmotic minipump; Substantia nigra pars compacta

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; APOMORPHINE; BENSERAZIDE; DOPAMINE; LEVODOPA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CAUDATE NUCLEUS; HISTOLOGY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PARKINSONISM; PRIORITY JOURNAL; RETROGRADE NERVE FIBER TRANSPORT; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMAL; CAUDATE NUCLEUS; LATERALITY; MACACA FASCICULARIS; MALE; MOTOR ACTIVITY; PARKINSON DISEASE, SECONDARY; POSTURE; PYRIDINES; STEREOTYPED BEHAVIOR; SUBSTANTIA NIGRA;

EID: 0023701184     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(88)90446-5     Document Type: Article

References (22)

1. Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
2. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra byN-methly-4-phenyl-1,2,3,6-tetrahydropyridine
3. + binds to neuromelanin
4. Chronic parkinsonism secondary to intravenous injection of meperidine analogues
5. Variability and functional recovery in theN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys
6. Reaction of the substantia nigra to massive basal ganglia infarction
7. + in the substantia nigra: a key to neurotoxicity?
8. 3H] mazindol autoradiography
9. MPTP induced parkinsonism
10. Chronic parkinsonism in humans due to product of meperidine-analogue synthesis
11. MPTP: current concepts and controversies
12. The organization of the ascending catecholamine neuron systems in the brain as revealed by the glyoxylic acid fluorescence method
13. Pigmentation in the nucleus substantiae nigrae of mammals
14. Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment
15. Neurotoxic effects ofN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the cat. Tyrosine hydroxylase immunohistochemistry
16. MPTP: a neurotoxin relevant to the pathophysiology of Parkinson's disease
17. The nucleus raphe dorsalis of the rat and its projection upon the caudatoputamen. A combined cytoarchitectonic, immunohistochemical and retrograde transport study
18. Behavioral and neurochemical effects of intra-caudate nucleus MPTP in the cat
19. Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigrostriatal dopamine system in the rat brain