The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) increases glial fibrillary acidic protein and decreases dopamine levels of the mouse striatum: Evidence for glial response to injury

Neuroscience Letters

Volumn 95, Issue 1-3, 1988, Pages 246-251

  Reinhard Jr , John F ^a   Miller, Diane B ^b   O'Callaghan, James P ^c  

^a GLAXOSMITHKLINE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c Neurotoxicology Division   (United States)

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; 1 Methyl 4 phenylpyridinium; Astrocyte; Dopamine; Glia; Glial fibrillary acidic protein; Neurotoxicant

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; NORADRENALIN; PARGYLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ASTROCYTE; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; GLIA CELL; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MESENCEPHALON; MOUSE; NONHUMAN; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMAL; ASTROCYTES; CORPUS STRIATUM; DOPAMINE; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; MICE; MICE, INBRED C57BL; PYRIDINES; TIME FACTORS;

EID: 0023700151     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(88)90665-9     Document Type: Article

References (18)

1. Quantitative changes in the synaptic vesicle proteins, synapsin 1 and p38, and the astrocyte specific protein, glial fibrillary acidic protein, are associated with chemical-induced injury to the rat central nervous system
2. The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal and limbic catecholamine neurons in white and black mice
3. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
4. Peptides released by ameboid microglia regulate astroglial proliferation
5. Neurochemical and histological characterization of neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse
6. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
7. Inhibition of monoamine oxidase produces protection against the dopaminergic toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
8. Selective (+)-amphetamine neurotoxicity on striatal dopamine nerve terminals in the mouse
9. 4
10. Chronic Parkinsonism in humans due to a product of mederidine-analog synthesis
11. Cerebellar hypoplasia in the Gunn rat is associated with quantitative changes in neurotypic and gliotypic proteins
12. Diethyldithiocarbamate increases the distribution of cadmium to brain but prevents cadmium-induced neurotoxicity
13. The neuropathology of MPTP-induced Parkinsonism in man and in experimental animals
14. Fast analysis of tissue catechols using a short, high-efficiency (3 μm) column and amperometric detection
15. Noradrenergic modulation of serotonin synthesis and release: inhibition by clonidine in vivo
16. Calcium-mediated breakdown of glial filaments and neurofilaments in rat optic nerve and spinal cord
17. Neurotoxic effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the cat
18. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications