Biological activities of novel recombinant tumor necrosis factor having N-terminal: Amino acid sequences derived from cytotoxic factors produced by THP-1 cells

Journal of Biological Response Modifiers

Volumn 7, Issue 6, 1988, Pages 587-595

  Soma, Gen Ichiro ^a   Tsuji, Yoshiaki ^a   Tanabe, Yoshiyuki ^a,b   Noguchi, Katsuo ^a   Kitahara Tanabe, Namiko ^a   Gatanaga, Tetsuya ^a   Inagawa, Hiroyuki ^a   Kawakami, Masanobu ^c   Mizuno, Den’ichi ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Acute toxicity; Antitumor spectrum; Cachectin activity; Clinical use; Key Words; Novel TNF; rTNF S

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; BLADDER CARCINOMA; CELL CULTURE; GENETIC ENGINEERING; HUMAN; HUMAN CELL; LUNG CARCINOMA; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMINO ACID SEQUENCE; BLADDER NEOPLASMS; COMPARATIVE STUDY; LIPOLYSIS; LIPOPROTEIN LIPASE; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; NEPHROBLASTOMA; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR;

EID: 0023697331     PISSN: 07326580     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Old LJ. Tumor necrosis factor (TNF). Science 1985;230:630-2.
2. Sugarman BJ, Aggarwal BB, Hass PE, Figari IS, Palladino MA Jr, Shepard HM. Recombinant human tumor necrosis factor-a: effects on proliferation of normal and transformed cells in vitro. Science 1985;22:943-5.
3. Nakano K, Abe S, Sohmura Y. Recombinant human tumor necrosis factor-I. Cytotoxic activity in vitro. Int J Immunopharmacol 1986;8:347-55.
4. Gabrilove JL, Starnes MF, Begas A, et al. Phase I studies of rTNF-a in patients with advanced cancer. Immunobiology 1987;175:12-3.
5. Taguchi T. Clinical studies of recombinant human tumor necrosis factor (rHu-TNF). Immunobiology 1987;175:37-8.
6. Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. N Engt J Med 1987,316:379- 85.
7. Beutler B, Cerami A. Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature (Lond) 1986;320:584-8.
8. Soma G-I, Kitahara N, Tsuji Y, et al. Improvement of cytotoxicity of tumor necrosis factor (TNF) by increase in basicity of its N-terminal region. Biochem Biophys Res Commun 1987;148:629-35.
9. Armstrong CA, Klostergaard J, Granger GA. Isolation and initial characterization of tumoricidal monokine(s) from the human monocytic leukemia cell line THP-1. JNCI 1985;74:l-9.
10. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 1970:227:680-5.
11. Ruff MR, Gifford GE. Purification and physicochemical characterization of rabbit tumor necrosis factor. J Immunol 1980;125:1671-7.
12. Gatanaga T, Takahashi K, Yamazaki M, Mizuno D, Abe S. Combination antitumor therapy with rabbit tumor necrosis factor and chemo- and therapeutic agents against murine tumors. Jpn J Cancer Res 1985,76:631-6.
13. Kawakami M, Murase T, Ogawa H, et al. Human recombinant TNF suppress lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells. J Biochem 1987;101:331-8.
14. Heicappell R, Naito S, Ichinose Y, Creasey AA, Lin LS, Fidler IJ. Cytostatic and cytolytic effects of human recombinant tumor necrosis factor on human renal cell carcinoma cell lines derived from a single surgical specimen. J Immunol 1987;138:1634-40.
15. Abe S, Yamamoto T, Inagawa H, Oshima H, Yamazaki M, Mizuno D. A possible role of gluco-corticoids: a natural and endogenous inhibitor to tumor necrosis factor. Immunobiology 1987;175:124.
16. Weber H, Valenzuela D, Lujber G, Gubler M, Weissmann C. Single amino acid changes that render human IFN-a2 biologically active on mouse cells. EMBO J 1987;6:591-8.
17. Old LJ. TNF: pleiotropic actions and interactions. Immunobiology 1987; 175:24.