Inhibition of HIV replication by amino-sugar derivatives

FEBS Letters

Volumn 237, Issue 1-2, 1988, Pages 128-132

  Fleet, George W J ^a   Karpas, Abraham ^b   Dwek, Raymond A ^a   Fellows, Linda E ^e   Tyms, A S ^c   Petursson, Sigthor ^a   Namgoong, Sung K ^a   Ramsden, Nigel G ^a   Smith, Paul W ^a   Son, Jong Chan ^a   Wilson, Francis ^a   Witty, David R ^a   Jacob, Gary S ^a,d   Rademacher, Thomas W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d PFIZER INC   (United States)

^e Glycobiology Unit Department of Biochemistry University of Oxford ^*

Author keywords

AIDS; Amino sugar; Glycosidase inhibitor; Glycosylation; HIV

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; ALPHA LEVO FUCOSIDASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; PRIORITY JOURNAL; VIRUS REPLICATION;

AMINO SUGARS; CELL LINE; COMPARATIVE STUDY; DNA REPLICATION; HIV; HIV-1; HIV-2; HUMAN; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION;

EID: 0023693720     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(88)80185-6     Document Type: Article

References (35)

1. CASTANOSPERMINE AND OTHER PLANT ALKALOID INHIBITORS OF GLUCOSIDASE ACTIVITY BLOCK THE GROWTH OF HIV
2. The biological activity of polyhydroxyalkaloids from plants
3. Alkaloidal glysosidase inhibitors from plants
4. Synthesis of 2-acetamido-1,5-imino-1,2,5-trideoxy-D-mannitol and of 2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol, a potent and specific inhibitor of a number of .BETA.-N-acetylglucosaminidases.
5. Synthesis from D-glucose of 1,5-dideoxy-1,5-imino-L-fucitol, a potent ?-L-fucosidase inhibitor