Gastric mucosal blood flow and mucosal protection

Journal of Clinical Gastroenterology

Volumn 10, Issue , 1988, Pages S114-S119

  Holm, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Blood flow velocity; Gastric mucosa; Gastric ulcer; Ischemic injury; Microcirculation; Microspheres; Neutrophils; Omeprazole; Prostaglandins; Reperfusion injury

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; OMEPRAZOLE; PROSTAGLANDIN E1; PROSTAGLANDIN E2;

HISTOLOGY; INTRAVITAL MICROSCOPY; MALE; MICROVASCULATURE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; STOMACH PROTECTION;

16,16-DIMETHYLPROSTAGLANDIN E2; ALPROSTADIL; ANIMAL; DINOPROSTONE; GASTRIC MUCOSA; MALE; MUCUS; NEUTROPHILS; OMEPRAZOLE; RATS; RATS, INBRED STRAINS;

EID: 0023686453     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/00004836-198812001-00017     Document Type: Article

References (26)

1. Mersereau WA, Hinchey EJ. Effect of gastric acidity on ulceration induced by hemorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology 1973;64:1130-5.
2. Leung FW, Itoh M, Hirabayashi K, Guth PH. Role of blood flow in gastric and duodenal mucosal injury in the rat. Gastroenterology 1985;88:281-9.
3. + back diffusion in the pathogenesis of acute gastric erosions. J Surg Res 1977;22:357-61.
4. McGreevy JM, Moody FG. Protection of gastric mucosa against aspirin-induced erosions by enhanced blood flow. Surg Forum 1977;28:357-9.
5. Esplugues J, Horis JM, Mart’i-Bonmat’i E, Marcillo EJ. Effects of beta-adrenoceptor drug stimulation on various models of gastric ulcer in rats. Br J Pharmacol 1982;76:587-94.
6. Bagge U, Braide M. Microcirculatory effects of white blood cells in shock. Prog Appl Microcirc 1985;7:43-50.
7. 2 at a cytoprotective dose. Gastroenterology 1985;88:1948-53.
8. 2 or sodium thiosulfate. Gastroenterology 1986;91:1415-26.
9. Miller TA. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol 1983;245:G601-G623.
10. Ahlquist DA, Duenes JA, Madson TH, Romero JC, Dozois RR, Malagelada JR. Prostaglandin generation from gastro duodenal mucosa: regional and species differences. Prostaglandins 1982;24:115-25.
11. Robert A, Nezamis JE, Lancaster C, Davis JP, Field SO, Hanchar AJ. Mild irritants prevent gastric necrosis through adaptive cytoprotection mediated by prostaglandins. Am J Physiol 1983;245:G113-G121.
12. Whittle BJR. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 1981;80:94-8.
13. Cohen MM, MacDonald WC. Mechanism of aspirin injury to human gastroduodenal mucosa. Prostaglandins Leukotrienes Med 1982;9:241-55.
14. Mattsson H, Andersson K, Larsson H. Omeprazole provides protection against experimentally induced gastric mucosal lesions. Eur J Pharmacol 1983;91:111-4.
15. Kollberg B, Isenberg JI, Johansson C. Cytoprotective effect of omeprazole on the rat gastric mucosa. In: Allen A, et al., eds. Mechanisms of mucosal protection in the upper intestinal tract. New York: Raven Press, 1984:351-6.
16. 2 on gastric mucosal microcirculation and basal acid output in the rat. Acta Physiol Scand 1986;127:313-21.
17. Holm-Rutili L. Effects of omeprazole on gastric mucosal microcirculation and acid secretion in the rat. Gastroenterology 1987;92:716-23.
18. Smith SM, Holm-Rutiti L, Perry MA, et al. Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat. Gastroenterology 1987;93:466-71.
19. Holm-Rutili L, Öbrink K-J. Rat gastric mucosal microcirculation in vivo. Am J Physiol 1985;248:G741-G746.
20. Arfors K-E, Bergqvist D, Intaglietta M, Westergren B. Measurements of blood flow velocity in the microcirculation. Ups J Med Sci 1975;80:27-33.
21. Intaglietta M, Tompkins WR, Richardson DR. Velocity measurements in the microvasculature of the cat omentum by on-line method. Microvasc Res 1970;2:462-73.
22. Wayland H, and Johnson PC. Erythrocyte velocity measurement in microvessels by a two-slit photometric method. J Appl Physiol 1967;22:333-7.
23. Szabo S, Pihan G, Trier JS. Alterations in blood vessels during gastric injury and protection. Scand J Gastroenterol 1986;21:92-6.
24. Boxer LA, Allen JM, Schmidt M, Yoder M, Baehner RL. Inhibition of polymorphonuclear leukocyte adherence by prostacyclin. J Lab Clin Med 1980;95:672-8.
25. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 1979;77:433-43.
26. Gannon B, Browning J, O’Brien P, Rogers P. Mucosal microvascular architecture of the fundus and body of human stomach. Gastroenterology 1984;86:866-75.