Human brain metabolism of morphine and naloxone

Pain

Volumn 35, Issue 2, 1988, Pages 121-127

  Wahlström, Agneta ^a   Winblad, Bengt ^a   Bixo, Marie ^a   Rane, Anders ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Glucuronidation; Human brain; Metabolism; Morphine; Naloxone

Indexed keywords

DRUG METABOLITE; MORPHINE; NALOXONE;

BRAIN; DRUG METABOLISM; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; FEMALE; GLUCURONATES; HUMAN; KINETICS; MALE; MIDDLE AGE; MORPHINE; NALOXONE; SUPPORT, NON-U.S. GOV'T;

EID: 0023685095     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(88)90219-9     Document Type: Article

References (20)

1. Enkephalin-like immunoreactivity in rat area postrema: ultrastructural localization and coexistence with serotonin
2. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry
3. Enkephalin receptors in the emetic chemoreceptor trigger zone of the dog
4. Morphine and codeine are endogenous components of human cerebrospinal fluid
5. Morphine-6-glucuronide has high affinity for the opioid receptor
6. N-demethylation of morphine in rat brain is localised in sites with high opiate receptor content
7. Isolation of naloxone-3-glucuronide from human urine
8. Analysis of morphine and its major metabolites by differential radioimmunoassay
9. Multiple opioid system and pain
10. Studies on the urinary metabolites of morphine in several mammalian species
11. Morphine intoxication in renal failure: the role of morphine-6-glucuronide
12. Morphine glucuronidation in the human fetal and adult liver
13. The natural (−)- and unnatural (+)-enantiomers of morphine. Comparative metabolism and effect of morphine and phenobarbital treatment
14. Preliminary characterization of enzymes for reduction of naloxone and naltrexone in rabbit and chicken liver
15. Oral morphine in cancer patients: in vivo kinetics and in vitro hepatic glucuronidation
16. Renal failure and use of morphine in intensive care
17. Determination of morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography
18. High doses of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretical implications
19. Urinary excretion of morphine and its metabolites in morphine-dependent subjects
20. Chemical reactivity of morphine-6-conjugates and their binding to rat brain