Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers

Journal of Biological Chemistry

Volumn 263, Issue 29, 1988, Pages 15064-15070

  Knauf, M J ^a   Bell, D P ^a   Hirtzer, P ^a   Luo, Z P ^a   Young, J D ^a   Katre, N V ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 2 DERIVATIVE; PROTEIN;

ANIMAL EXPERIMENT; CHEMICAL MODIFICATION; GLOMERULUS FILTRATION RATE; MOLECULAR SIZE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; GLYCERIDES; HALF-LIFE; INTERLEUKIN-2; ISOELECTRIC FOCUSING; MALE; METABOLIC CLEARANCE RATE; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; RATS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0023683508     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)