A genetic linkage map of the human genome

Cell

Volumn 51, Issue 2, 1987, Pages 319-337

  Donis Keller, Helen ^a   Green, Philip ^a   Helms, Cynthia ^a   Cartinhour, Samuel ^a   Weiffenbach, Barbara ^a   Stephens, Karen ^a   Keith, Tim P ^a   Bowden, Donald W ^a   Smith, Douglas R ^a   Lander, Eric S ^b   Botstein, David ^c   Akots, Gita ^a   Rediker, Kenneth S ^a   Gravius, Thomas ^a   Brown, Valerie A ^a   Rising, Marcia B ^a   Parker, Carol ^a   Powers, Jody A ^a   Watt, Diane E ^a   Kauffman, Erick R ^a   Bricker, Angela ^a   Phipps, Pamela ^a   Muller Kahle, Hans ^a   Fulton, Thomas R ^a   Ng, Siu ^a   Schumm, James W ^a   Braman, Jeffrey C ^a   Knowlton, Robert G ^a   Barker, David F ^a   Crooks, Steven M ^a   Lincoln, Steven E ^b   Daly, Mark J ^b   Abrahamson, Jeff ^b   more..

^a Diagnostic Services Division   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME MAP; GENE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; HUMAN; PEDIGREE; SEXUAL DEVELOPMENT;

CHROMOSOME MAPPING; GENES; HUMAN; LINKAGE (GENETICS); PEDIGREE; POLYMORPHISM (GENETICS); RECOMBINATION, GENETIC; SEX CHARACTERISTICS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023663060     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(87)90158-9     Document Type: Article

References (136)

1. Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphis
2. Clones from the human gene complex coding for salivary proline-rich proteins
3. Restriction sites containing CpG show a higher frequency of polymorphism in human DNA
4. A locus on chromosome 11p with multiple restriction site polymorphisms
5. RFLP analysis of probes containing repetitive DNA using probe prehybridization
6. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17
7. A genetic linkage map of 63 DNA markers on human chromosome 7
8. Double cos site vectors: simplified cosmid cloning
9. Polymorphic DNA region adjacent to the 5' end of the human insulin gene
10. Chromosomal walking and jumping to isolate DNA from the ace and rosy loci and bithorax complex in Drosophila melanogaster
11. Detection of a frequent restriction fragment length polymorphism in the human T-cell antigen receptor beta chain locus
12. Localization of the gene for familial adenomatous polyposis in chromosome 5
13. Construction of a genetic linkage in man using restriction fragment length polymorphism
14. Radiation-induced basepair substitution mutagenesis in single-stranded DNA phage M13
15. The relationship of the age of the female to crossing over in the third chromosome of Drosophila melanogaster
16. Regional assignments of three polymorphic DNA segments on human chromosome 15
17. The cytogenetics of corn
18. Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13
19. Genetic origin of mutations predisposing to retinoblastoma
20. The interaction of knobs and B chromosomes of maize in determining the level of recombination
21. Gene transfer and molecular cloning of the human NGF receptor
22. Transformation of NIH 3T3 cells by a human c-sis cDNA clone
23. A variable tandem repeat locus mapped to chromosome band 10q26 is amplified and rearranged in leukocyte DNAs of two cancer patients
24. Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal
25. Molecular cloning of a new transforming gene from a chemically transformed human cell line
26. DNA RFLPs and heterozgosity in the human genome
27. An estimate of unique DNA sequence heterozygosity in the human genome
28. Isolation and subregional mapping of an arbitrary cloned probe detecting a common RFLP on human chromosome 2
29. Linkage analysis of two cloned sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome
30. Recombination percentages
31. Assignment of RFLP loci D3S3, D20S4, and D15S1 to chromosomes 3p, 20, and 15, respectively. (HGM7)
32. Highly polymorphic RFLP probes as diagnostic tools
33. Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms
34. Bipolar affective disorders linked to DNA markers on chromosome 11
35. Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumors
36. A systematic approach for detecting high-frequency restriction fragment polymorphisms using large genomic probes
37. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
38. Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere
39. Familial hypercholesterolemia
40. Linkage analysis of a DNA marker localized to 20p12 and multiple endocrine neoplasia type 2A
41. A pseudoautosomal gene in man
42. Localization and linkage of three polymorphic DNA sequences on human chromosome 20
43. Isolation and localization of DNA segments from specific human chromosomes
44. A polymorphic DNA marker genetically linked to Huntington's disease
45. Sex ratio and unisexual sterility in hybrid animals
46. A new method for purifying lambda from phage lysates
47. Genetics
48. Highly variable regions of DNA flank the human globin genes
49. Human renin gene: structure and sequence analysis
50. Ananonymous single copy chromosome 22 clone, D22S10 (22c1-18) identifies an RFLP with Pstl
51. The X chromosome shows less genetic variation at restriction sites than the autosomes
52. Chiasma derived genetic maps and recombination fractions: chromosome 1
53. Rapid and efficient cosmid cloning
54. Isolation and sequence of a human apolipoprotein Cll cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein Cll
55. Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7
56. A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7
57. Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms
58. Mapping complex genetic traits in humans: new strategies using a complete RFLP linkage map
59. Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children
60. Construction of multilocus genetic linkage maps in humans
61. MAPMAKER an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
62. Strategies for multilocus linkage analysis in humans
63. Further studies on bivalent chiasma frequency in human males with normal karyotypes
64. Further studies on chiasma distribution and interference in the human male
65. The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA
66. Construction of a map of the short arm of chromosome 6
67. Human retinoblastoma gene: cloning, identification and sequence
68. Isolation and characterization of human myosin heavy chain genes
69. A primary genetic linkage map of chromosome 13q
70. Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells
71. Human cytoplasmic superoxide dismutase cDNA clone: a probe for studying the molecular biology of Down Syndrome
72. The genetic analysis of meiosis in female Drosophila melanogaster
73. BgIII RFLP recognized by a human IRBP cDNA localized to chromosome 10
74. A highly polymorphic locus in human DNA revealed by cosmid-derived probes
75. Very close linkage between D2S1 and ACP1 on chromosome 2p
76. Insertion/deletion polymorphisms in human salivary proline-rich protein genes
77. Chiasma studies in the silkworm Bombyx mori L
78. A linked genetic marker for multiple endocrine neoplasia type 2a on chromosome 10
79. Structural and evolutionary relationships among five members of the human gamma-crystallin gene family
80. Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene
81. No crossing over in the male of Drosophila of genes in the second and third pair of chromosomes
82. Assignment of two unique DNA sequences which define restriction fragment length polymorphisms to chromosomes 3 and 18
83. Sequential tests for the detection of linkage
84. An inferred chiasma map of Drosophila melanogaster
85. Data and theory for a revised chiasma map of man
86. Multipoint linkage analysis
87. Variable number of tandem repeat (VNTR) markers for human gene mapping
88. DNA polymorphic loci mapped to human chromosomes 3, 5, 9, 11, 17, 18, and 22
89. Isolation of cDNA clones coding for the B subunit of human B-hexosaminidase
90. Occurrence of a transposition from the X chromosome long arm to the Y chromosome short arm during human evolution
91. Linkage physical mapping and DNA sequence analysis of pseudoautosomal loci on the human X and Y chromosomes
92. Organization of the HPRT gene and related sequences in the human genome
93. Prenatal diagnosis of sickle cell anemia by restriction endonuclease analysis: Hind III polymorphisms in gammaglobin genes extend test applicability
94. Isolation of a cDNA clone for human antithrombin III
95. Isolation and characterization of the human catalase gene
96. A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16
97. Male and female recombination fraction of the nail-patella ABO linkage in man
98. Different rates of crossing over in male and female gametes of maize
99. Different frequency in the recovery of crossover products from male and female gametes of plants hypoploid for B-A translocation in maize
100. A gradient of sex-linkage in the pseudoautsomal region of the human sex chromosomes
101. Cloning the gene for an inherited human disorder — chronic granulomatous disease — on the basis of its chromosomal location
102. The genetic defect causing familial Alzheimer's disease maps on chromosome 21
103. Identification of more than 500 restriction fragment length polymorphisms by screening random genomic clones
104. New highly informative RFLPs at the D17S2 and MYH2 loci and linkage between MYH2 and D17S1. (HGM8)
105. Loss of genes on chromosome 22 in tumorogenesis of human acoustic neuroma
106. Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene
107. Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19
108. Two RFLPs identified by a human chromosome #2 clone at 2p15-2p16 (HGM8 assignment no. D2S5)
109. Pseudoautosomal DNA sequences in the pairing regions of the human sex chromosomes
110. Assignment of multiple endocrine neoplasia type 2a to chromosome 10 by linkage
111. The development of human linkage analysis
112. Mapping of human class 1 alcohol dehydrogenase (ADH)
113. Assignment of ADH1, ADH2 and ADH3 genes (class I ADH) to human chromosome 4q21-4q25
114. Evolution of sickle cell variant gene
115. Chromosome 5 allele loss in human colorectal carcinomas
116. Abelson murine leukemia virus: molecular cloning of infectious integrated proviral DNA
117. Isolation and characterization of cloned DNA from a DNA bank enriched for human chromosome 21 (HGM7)
118. The linear arrangment of six sex-linked factors in Drosophila as shown by their mode of association
119. Introduction of homologous DNA segments into mammalian cells induces mutations in the cognate gene
120. RFLP associated with the proalpha2(I) gene of human type I procollagen
121. Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker
122. Human chromosome-specific DNA libraries construction and availability
123. Localization of cystic fibrosis locus to human chromosome 7cen-q22
124. Construction of linkage maps with DNA markers for human chromosomes
125. A closely linked genetic marker for cystic fibrosis
126. Construction of human genetic linkage maps: I. Progress and perspectives
127. Report of the committee on human gene mapping by recombinant DNA techniques
128. Detection of restriction fragment length polymorphism at the centromere of human chromosomes by using chromosome specific alpha satellite DNA probes: implications for development of centromere-based genetic linkage maps
129. Assignment of the first random restriction fragment length polymorphism (RFLP) locus (D14S1) to a region of human chromosome 14
130. Factors which equalize the representation of genome segments in recombinant libraries
131. High-resolution chromosomal localization of human genes for amylase, pro-opiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization