A hyperconversion mechanism generates the chicken light chain preimmune repertoire

Cell

Volumn 48, Issue 3, 1987, Pages 379-388

  Reynaud, Claude Agnès ^a   Anquez, Viviane ^a   Grimal, Hélène ^a   Weill, Jean Claude ^a  

^a INSTITUT JACQUES MONOD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULINS, J CHAIN; IMMUNOGLOBULINS, LAMBDA CHAIN;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BURSA FABRICII; CHICK EMBRYO; CHICKEN; CYTOLOGY; GENE CONVERSION; GENETIC VARIABILITY; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; NUCLEOTIDE SEQUENCE;

ANIMAL; ANTIBODY DIVERSITY; BASE SEQUENCE; BURSA OF FABRICIUS; CHICK EMBRYO; CHICKENS; GENE CONVERSION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, J-CHAIN; IMMUNOGLOBULINS, LAMBDA-CHAIN; SUPPORT, NON-U.S. GOV'T; VARIATION (GENETICS);

EID: 0023652339     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(87)90189-9     Document Type: Article

References (39)

1. Molecular events during maturation of the immune response to oxazolone
2. 35S label as an aid to rapid DNA sequence determination
3. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
4. Development and function of the immunoglobulin-producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production
5. Immunoglobulin V region variants in hybridoma cells: II. Recombination between V genes
6. Isolation of the chicken β-globin gene and a linked embryonic β-like globin gene from a chicken DNA recombinant library
7. Somatic recombination of duplicated genes an hypothesis on the origin of antibody diversity
8. Correct transcription of an immunoglobulin gene requires an upstream fragment containing conserved sequence elements
9. Clusters of point mutations are found exclusively around rearranged antibody variable genes
10. Endonucleolytic activity that cleaves immunoglobulin recombination sequences
11. Bursectomy in ovo blocks the generation of immunoglobulin diversity
12. Defect in the generation of light chain diversity in bursectomized chickens
13. Variable region genes for the immunoglobulin framework are assembled from small fragments of DNA-A hypothesis
14. + B-cell lymphoma
15. Translocation alters the activation rate of a trypanosome surface antigen gene
16. A bacteriophage lambda vector for cloning large DNA fragments made with several restriction enzymes
17. Ontogeny of B cells in the chicken. I. Sequential developmental of clonal diversity in the Bursa
18. The molecular evolution of the immune response
19. Sequencing end-labeled DNA with base-specific chemical cleavages
20. A new pair of M13 vectors for selecting either DNA strand of double digest restriction fragments
21. The regulation of yeast mating-type chromatin structure by SIR: an action at a distance affecting both transcription and transposition
22. Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence
23. Differences between germline and rearranged immunoglobulin V coding sequences suggest a localized mutation mechanism
24. Counting components of the chicken's B cell system
25. Immunoglobulin bearing stem cells for clones of B (bursa-derived) lymphocytes
26. H joining mechanism in heavy-chain-negative (nul) pre-B cells results in heavy chain production
27. A single rearrangement event generates most of the chicken immunoglobulin light chain diversity
28. The use of incomplete genes for the construction of a Trypanosoma equiperdum variant surface glycoprotein gene
29. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response
30. DNA sequencing with chain-terminating inhibitors
31. Somatic mutation of immunoglobulin light-chain variable-region genes
32. The genetic basis of antibody variability
33. Detection of specific sequences among DNA fragments separated by gel electrophoresis
34. High frequency targeting of genes to specific sites in the mammalian genome
35. Bursal and post-bursal stem cells in the chicken
36. The pUC plasmids: an M13 mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers
37. Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius
38. Questioning the role of the embryonic bursa in the molecular differentiation of B lymphocytes