Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

Cell

Volumn 48, Issue 3, 1987, Pages 369-378

  Thompson, Craig B ^a   Neiman, Paul E ^b  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^b FRED HUTCHINSON CANCER RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULINS, LAMBDA CHAIN;

ALLELE; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BURSA FABRICII; CHICK EMBRYO; CHICKEN; CHROMATIN; CYTOLOGY; GENE CONVERSION; GENETIC VARIABILITY; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; SEQUENCE HOMOLOGY;

ALLELES; ANIMAL; ANTIBODY DIVERSITY; B-LYMPHOCYTES; BURSA OF FABRICIUS; CHICK EMBRYO; CHICKENS; CHROMATIN; GENE CONVERSION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS, LAMBDA-CHAIN; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; VARIATION (GENETICS);

EID: 0023652303     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(87)90188-7     Document Type: Article

References (36)

1. H fusions
2. Regulation of genome rearrangement events during lymphocyte differentiation
3. Avian leukosis virus infection: analysis of viremia and DNA integration in susceptible and resistant chicken lines
4. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin
5. Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins, and antibody production
6. Immune capacity of the chicken bursectomized at 60H of incubation
7. Clusters of point mutations are found exclusively around rearranged antibody variable genes
8. Partial amino acid sequences of chicken and turkey immunoglobulin light chains
9. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
10. B-cell ontogeny in the chicken
11. Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
12. H segmental elements during vertebrate evolution
13. Immune capacity of the chicken bursectomized at 60 HR of incubation: surface immunoglobulin and B-L (la-like) antigen-bearing cells
14. Defect in the generation of light-chain diversity in bursectomized chickens
15. H genes
16. Molecular mechanisms for gene conversion in higher cells
17. The organization of immunoglobulin genes and the origin of their diversity
18. Ontogeny of B cells in the chicken. I. Sequential development of clonal diversity in the bursa
19. The molecular evolution of the immune response
20. Structural analysis of monoclonal anti-arsonate antibodies: idiotypic specificities are determined by the heavy chains
21. Viral DNA in bursal lymphomas induced by avian leukosis viruses
22. Counting components of the chicken's B cell system
23. The ontogeny and cloning of B cells in the bursa of Fabricius
24. Complete sequence of a chicken λ light chain immunoglobulin derived from the nucleotide sequence of its mRNA
25. A single rearrangement event generates most of the chicken immunoglobulin light chain diversity
26. A hyperconversion mechanism generates the chicken light chain preimmune repertoire
27. Sequence analysis of non-expressed immunoglobulin heavy chain loci in clonally related, somatically mutated hybridoma cells
28. Detection of specific sequences among DNA fragments separated by gel electrophoresis
29. Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes
30. Monoclonal antibodies reveal the structural basis of antibody diversity
31. Normal and neoplastic B cell development in the bursa of Fabricius
32. Expression of the c-myb proto-oncogene during cellular proliferation
33. Somatic generation of antibody diversity
34. The joining of V and J gene segments creates antibody diversity
35. Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius
36. H gene segments