Blood-brain barrier transcytosis of insulin in developing rabbits

Brain Research

Volumn 420, Issue 1, 1987, Pages 32-38

  Duffy, Kent R ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain capillary; Peptide transport

Indexed keywords

INSULIN I 125; RADIOISOTOPE;

AUTORADIOGRAPHY; BLOOD AND HEMOPOIETIC SYSTEM; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; DEVELOPMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PERIPHERAL VASCULAR SYSTEM; RABBIT;

ANIMAL; AUTORADIOGRAPHY; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INSULIN; RABBITS; SERUM ALBUMIN; SUPPORT, NON-U.S. GOV'T;

EID: 0023636719     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(87)90236-8     Document Type: Article

References (36)

1. Thyrotropin-releasing hormone-degrading activity of neonatal human plasma
2. Insulin binding to microvascular endothelium of intact heart: a kinetic and morphometric analysis
3. Regional concentration of insulin in the rat brain
4. Serum bioavailability and tissue metabolism of testosterone and estradiol in rat salivary gland
5. The influence of insulin upon the metabolism of glucose by the brain
6. Brain insulin binding and content are altered by streptozotocin treatment in rats
7. A direct in vitro demonstration of insulin binding to isolated brain microvessels
8. Enhanced insulin binding to blood-brain barrier in vivo and to brain microvessels in vitro in newborn rabbits
9. Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels
10. Insulin binding to the blood-brain barrier in the streptozotocin diabetic rat
11. Immunohistological localization of gamma-glutamyl transpeptidase in cerebellum at light and electron microscope levels
12. The failure of rat hypothalamic tissues to take up labeled insulin in vivo or to respond to insulin in vitro
13. Identification of insulin in rat brain
14. Insulin receptors are widely distributed in the central nervous system of the rat
15. Capacity for energy metabolism in microvessels isolated from rat brain
16. Kinetic analysis of plasma insulin disappearance in non-ketotic diabetic patients and in normal subjects
17. Selective externalization of the transferrin receptor by sheep reticulocytes in vitro
18. Carrier-mediated transport of thyroid hormones through the blood-brain barrier. Primary role of albumin-bound hormone
19. Neuropeptides and the blood-brain barrier
20. Receptor-mediated peptide transport through the blood-brain barrier
21. Brain metabolism: a perspective from the blood-brain barrier
22. Human blood-brain barrier insulin receptor
23. Absence of albumin receptor on brain capillaries in vivo or in vitro
24. Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46-K protein
25. Stimulation of ornithine decarboxylase activity in neuronal cell culture: potential role of insulin
26. Insulin-mediated regulation of neuronal maturation
27. Stimulation of ornithine decarboxylase activity by insulin in developing rat brain
28. Localization of steroid hormone target neurons by autoradiography
29. Insulin: is it a nerve survival factor?
30. Insulin binding and vesicular ingestion in capillary endothelium
31. Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese Zucker rats
32. Influence of the insulin-sensitive central nervous system glucoregulator receptor on hepatic glucose metabolism
33. Insulin binds to brain blood vessels in vivo
34. Insulin binding sites in the rat brain: in vivo localization to the circumventricular organs by quantitative radioautography
35. Relationship between plasma and cerebrospinal fluid insulin levels of dogs
36. Characterization of insulin stimulation of the incorporation of precursors into macromolecules in cultured rat brain cells