An acridine-linked oligodeoxynucleotide targeted to the common 5' end of trypanosome mRNAs kills cultured parasites

Gene

Volumn 61, Issue 3, 1987, Pages 307-315

  Verspieren, P ^a   Cornelissen, A W C A ^b   Thuong, N T ^c   Helene C ^a   Toulme J J ^d  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

^d NONE

Author keywords

antisense DNA; DNA RNA hybrids; intercalating agents; mini exon; Recombinant DNA; translation regulation; Trypanosoma brucei

Indexed keywords

ACRIDINE; ANTIPROTOZOAL AGENT; OLIGODEOXYNUCLEOTIDE; RADIOISOTOPE;

EXON; GENETIC ENGINEERING; HEREDITY; NONHUMAN; PROTOZOON; RNA TRANSLATION; TRYPANOSOMA BRUCEI;

ACRIDINES; ANIMAL; DNA, RECOMBINANT; EXONS; OLIGODEOXYRIBONUCLEOTIDES; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSLATION, GENETIC; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0023635433     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(87)90194-6     Document Type: Article

References (40)

1. Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribo-nucleoside methylphosphonates
2. Nouvelles substances α forte affinité spécifique pour des séquences d'acides nucléiques: oligodésoxynucléotides liés de faéon covalente α un agent intercalant
3. Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligo-deoxynucleotides
4. Oligodeoxynucleotides covalently linked to intercalating dyes as base sequence-specific ligands. Influence of dye attachment site
5. Oligothymidylates Substitubs en Position 3’ Par un Derive De L'Acridine
6. Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxy-ribonucleotides
7. Hybridization arrest of globin synthesis in rabbit reticulocyte lysates and cells by oligodeoxyribonucleoside methylphosphonates
8. Discontinuous transcription and antigenic variation in trypanosomes
9. Cultivation and in vitro cloning of procyclic culture forms of Trypanosoma brucei in a semidefined medium
10. Enzymatic amplification of translation inhibition of rabbit β-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents
11. Anti-messenger oligodeoxynucleotides: specific inhibition of rabbit β-globin synthesis in wheat germ extracts and Xenopus oocytes
12. Purification of eukaryotic messenger RNA
13. The common 5' terminal sequence on trypanosome mRNAs: a target for anti-messenger oligo-deoxynucleotides
14. Identification, purification and properties of clone-specific glycoproteins antigens constituting the surface coat of Trypanosoma brucei
15. Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species
16. The role of antisense RNA in gene regulation
17. Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length
18. Quantitative hybridization-arrest of mRNA in Xenopus oocytes using single-stranded complementary DNA or oligodeoxynucleotide probes
19. Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA
20. In vivo labelling of intermediates in the discontinuous synthesis of mRNAs in Trypanosoma brucei
21. Proton and phosphorus nuclear magnetic resonance studies of an oligothymidylate covalently linked to an acridine derivative and of its binding to complementary sequences
22. Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.
23. Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligodeoxynucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages
24. Cloning and characterization of a Leishmania gene encoding a RNA spliced leader sequence
25. The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations
26. Α-DNA II. Synthesis of unnatural Α-anomeric oligodeoxyribonucleotides containing the four usual bases and study of their substrate activities for nucleases
27. Identification of a novel Y branch structure as an intermediate in trypanosome mRNA processing: evidence for trans-splicing
28. Sequences homologous to variant antigen mRNA spliced leader in Trypanosomatidae which do not undergo antigenic variation
29. Mechanism for the autogenous control of the crp operon: transcriptional inhibition by a divergent RNA transcript
30. Biochemical peculiarities of trypanosomes, African and South American
31. Destabilization of messenger RNA/complementary DNA duplexes by the elongating 80 S ribosome
32. Antiviral effect of an oligo (nucleoside methyl-phosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5
33. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribo-nucleotide
34. Oligo-alpha-deoxynucleotides covalently linked to an intercalating agent. Double helices with parallel strands are formed with complementary oligobeta-deoxynucleotides
35. Evidence for trans-splicing in trypanosomes
36. Oligo (alpha-deoxynucleotides) covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion
37. Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents.
38. The 35-nucleotide spliced leader sequence is common to all trypanosome messenger RNAs
39. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
40. Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligodeoxynucleotides complementary to viral RNA