Summary review of the health effects associated with phenol

Toxicology and Industrial Health

Volumn 3, Issue 4, 1987, Pages 535-568

  Bruce, Robert M ^a   Santodonato, Joseph ^b   Neal, Michael W ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b SYRACUSE RESEARCH CORPORATION   (United States)

Author keywords

air quality; fate; occurrence; phenol; public health; toxicology

Indexed keywords

PHENOL;

ANIMAL EXPERIMENT; CARCINOGENICITY; COMA; CONVULSION; ENVIRONMENTAL EXPOSURE; FETOTOXICITY; HUMAN; INHALATION; INTOXICATION; MUSCLE WEAKNESS; MUTAGENICITY; OCCUPATIONAL EXPOSURE; REVIEW; RISK ASSESSMENT; SKIN ABSORPTION; TERATOGENICITY; TOXICOKINETICS;

ANIMAL; HUMAN; PHENOLS; RISK FACTORS;

EID: 0023633542     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/074823378700300407     Document Type: Review

References (103)

1. Adlard, E.R., Milne, C.B. and Tindle, P.E. (1981). The determination of phenol in urine by enzymatic hydrolysis/ headspace gas chromatography. Chromatographia 14: 507-509.
2. American Conference Of Governmental Industrial Hygienists. (1952). Threshold limit values for 1952. AMA Arch. Ind. Hyg. Occup. Med. 6: 178-180.
3. American Conference Of Governmental Industrial Hygienists. (1961). Threshold limit values for 1961. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.
4. American Conference Of Governmental Industrial Hygienists. (1980). Documentation of the threshold limit values. Fourth edition. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, Inc., p. 328.
5. American Conference Of Governmental Industrial Hygienists. (1984). Threshold limit values for chemical substances and physical agents in the work environment and biological exposure indices with intended changes for 1984-1985. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.
6. Babich, H. and Davis, D.L. (1981). Phenol: a review of environmental and health risks. Regul. Toxicol. Pharmacol. 1: 90-109.
7. Baker, E.L., Landrigan, P.J., Bertozzi, P.E., Field, P.H., Basteyns, B.J. and Skinner, H.G. (1978). Phenol poisoning due to contaminated drinking water. Arch. Environ. Health 33: 89-94.
8. Bennett, I.L., Jr., James, D.F. and Golden, A. (1950). Severe acidosis due to phenol poisoning: report of two cases. Ann. Intern. Med. 32: 324-327.
9. Berenblum, I. (1985). Challenging problems in cocarcinogenesis. Cancer Res. 45: 1917-1921.
10. Boutwell, R.K. and Bosch, D.K. (1959). The tumor-promoting action of phenol and related compounds for mouse skin. Cancer Res. 19: 413-424.
11. Braun, A.G., Buckner, C.A., Emerson, D.J. and Nichinson, B.B. (1982). Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents. Proc. Natl. Acad. Sci. U.S.A. 79: 2056-2060.
12. Brodzinsky, R. and Singh, H.B. (1982). Volatile organic chemicals in the atmosphere: an assessment of available data. Research Triangle Park, NC: U.S. Environmental Protection Agency, Environmental Sciences Research Laboratory; EPA report no. EPA-600/ 3-83-027A. Available from NTIS, Springfield, VA;PB83-195503.
13. Callahan, M.A., Slimak, M.W., Gabel, N.W., May, I.P. and Fowler, C.F. (1979). Water-related environmental fate of 129 priority pollutants. Volume II: halogenated aliphatic hydrocarbons, halogenated ethers, monocyclic aromatics, phthalate esters, polycyclic aromatic hydrocarbons, nitrosamines, and miscellaneous compounds. Washington, DC: U.S. Environmental Protection Agency, Office of Water Planning and Standards; EPA report no. EPA-440/ 4-79-029b. Available from NTIS, Springfield, VA;PB80-204381.
14. Capel, I.D., French, M.R., Millburn, P., Smith, R.L. and Williams, R.T. (1972a). The fate of [14C] phenol in various species. Xenobiotica 2: 25-34.
15. Capel, I.D., French, M.R., Millburn, P., Smith, R.L. and Williams, R.T. (1972b). Species variations in the metabolism of phenol. Biochem. J. 127: 25-26.
16. Capel, I.D., Millburn, P. and Williams, R.T. (1974). Route of administation and the conjugation of phenol in hens. Biochem. Soc. Trans. 2: 875-876.
17. Carter, W.P.L., Winer, A.M. and Pitts, J.N., Jr. (1981). Major atmospheric sink for phenol and the cresols. Reaction with the nitrate radical. Environ. Sci. Techol. 15: 829-831.
18. Cassidy, M.K. and Houston, J.B. (1984). In vivo capacity of hepatic and extrahepatic enzymes to conjugate phenol. Drug Metab. Dispos. 12: 619-624.
19. CHEMICAL ENGINEERING NEWS. (1984). Production by the U.S. chemical industry: output makes a strong recovery. Chem. Eng. News 62 (24):34-40.
20. Chemical Marketing Report. (1984). Chemical profile: Chem. Mark. Rep. 226 (1):50.
21. Clarke, T.W. and Brown, E.D. (1906). The value of alcohol in carbolic acid poisoning. A clinical and experimental study. JAMA 46: 782-790.
22. Conning, D.M. and Hayes, J.J. (1970). The dermal toxicity of phenol: An investigation of the most effective first-aid measures. Br. J. Ind. Med. 27: 155-159.
23. Deichmann, W.B. (1944). Phenol studies, V: The distribution, detoxification, and excretion of phenol in the mammalian body. Arch. Biochem. 3: 345-355.
24. Deichmann, W.B. and Witherup, S. (1944). Phenol studies, VI: The acute and comparative toxicity of phenol and o-, m-, and p-cresols for experimental animals. J. Pharmacol. Exp. Ther. 80: 233-240.
25. Deichmann, W.B. and Keplinger, M.L. (1981). Phenols and phenolic compounds. In: Patty's Industrial Hygiene and Toxicology: V. 2A, Toxicology (B.D. Clayton and F.E. Clayton eds.), 3rd. rev. ed., pp. 2567-2627. John Wiley and Sons, New York, NY.
26. Deichmann, W.B., Kitzmiller, K.V. and Witherup, S. (1944). Phenol studies, VII: Chronic phenol poisoning, with special references to the effects upon experimental animals of the inhalation of phenol vapor. Am. J. Clin. Pathol. 14: 273-277.
27. Dalaney, J.L. and Hughes, T.W. (1979). Source assessment: manufacture of acetone and phenol from cumene. Research Triangle Park, NC: U.S. Environmental Protection Agency, Industrial Environmental Research Laboratory; EPA report no. EPA-600/ 2-79-019D. Available from NTIS, Springfield, VA;PB80-150592.
28. Demerec, M., Bertani, G. and Flint, J. (1951). A survey of chemicals for mutagenic action on E. coli. Am. Nat. 85: 119-136.
29. Dow Chemical Company. (1976). References and literature review pertaining to toxicological properties of phenol. Toxicol. Res. Lab. (unpub. manuscript).
30. Duplay, S. and Cazin, M. (1891). On the effect of phenol on animals. C.R. Acad. Sci. 112: 627.
31. Elkins, H.B. (1959). The chemistry of industrial toxicology. 2nd edition, p. 116. New York, NY: John Wiley and Sons.
32. Farquharson, M.E., Gage, J.C. and Northover, J. (1958). The biological action of chlorophenols. Br. J. Pharmacol. 13: 20-24.
33. Flickinger, C.W. (1976). The benzenediols: catechol, resorcinol and hydroquinone—A review of the industrial toxicology and current industrial exposure limits. Am. Ind. Hyg. Assoc. J. 37: 596-606.
34. Florin, I., Rutberg, L., Curvall, M. and Enzell, C.R. (1980). Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology 15: 219-232.
35. Folin, O. and Denis, W. (1915). The excretion of free and conjugated phenols and phenol derivatives. J. Biol. Chem. 22: 309-320.
36. Federal Register. Proposed guidelines for carcinogenic risk assessment; request for comments. 49: 46294-46301 (November 23).
37. Franz, T.J. (1975). Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 64: 190-195.
38. Freese, E., Levin, B.C., Pearce, R., Sreevalsan, T., Kaufman, J.J., Koski, W.W. and Semo, N.M. (1979). Correlation between the growth inhibitory effects, partition coefficients and teratogenic effects of lipophilic acids. Teratology 20: 413-439.
39. Gad-el-Karim, M.M., Rammanugam, S., Ahmed, A.E. and Legator, M.S. (1985). Benzene myeloclastogenicity: a function of its metabolism. Am. J. Ind. Med. 7: 475-484.
40. Geill, C. (1888). Clinical studies on acute phenol poisoning. Prager Med. Wochenschr. 13: 411.
41. Gocke, E., King, M.T., Eckhardt, K. and Wild, D. (1981). Mutagenicity of cosmetics ingredients licensed by the European communities. Mutat. Res. 90: 91-109.
42. Greek, B.F. (1984). Phenol, vinyl acetate face tightening supply. Chem. Eng. News 62 (39): 10-12.
43. Haworth, S., Lawlor, T., Mortelmans, K., Speck, W. and Zeiger, E. (1983). Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen. 5(Suppl. 1):3-142.
44. Heller, V.G. and Pursell, L. (1938). Phenol-contaminated waters and their physiological action. J. Pharmacol. Exp. Ther. 63: 99-107.
45. Hendry, D.G. and Kenley, R.A. (1979). Atmospheric reaction products of organic compounds. Washington, DC: U.S. Environmental Protection Agency, Office of Toxic Substances; pp. 20 and 46; EPA report no. EPA-560/ 12-79-001. Available from NTIS, Springfield, VA; PB-301384.
46. Hogg, S.I., Curtis, C.G., Upshall, D.G. and Powell, G.M. (1981). Conjugation of phenol by rat lung. Biochem. Pharmacol. 30: 1551-1555.
47. Ikeda, M. and Ohtsuji, H. (1969). Hippuric acid, phenol, and tricholoacetic acid levels in the urine of Japanese subjects with no known exposure to organic solvents. Br. J. Ind. Med. 26: 162-164.
48. Jones-Price, C., Ledoux, T.A., Reel, J.R., Langhoff-Paschke, L. and Marr, M.C. (1983a). Teratologic evaluation of phenol (CAS No. 108-95-2) in CD-1 mice. Laboratory study: September 18, 1980 to January 12, 1981. Research Triangle Park, NC: Research Triangle Institute. Available from NTIS, Springfield, VA;PB85-104461 /XAB.
49. Jones-Price, C., Ledoux, T.A., Reel, J.R., Fisher, P.W., Langhoff-Paschke, L. and Marr, M.C. (1983b). Teratologic evaluation of phenol (CAS No. 108-95-2) in CD rats. Research Triangle Park, NC: Research Triangle Institute. Available from NTIS, Springfield, VA;PB83-247726.
50. Kao, J., Bridges, J.W. and Faulkner, J.K. (1979). Metabolism of [14C] phenol by sheep, pig and rat. Xenobiotica 9: 141-147.
51. Kociba, R.J., Kalnins, R.V., Wade, C.E., Garfield, E.L. and Fishbeck, W.A. (1976). Elevated urinary phenol levels in beagle dogs treated with salol. Am. Ind. Hyg. J. 37: 183:191.
52. Korshunov, S.F. (1974). Early and late embryotoxic effects of phenol (experimental data). In Gigiena truda i sostoyanie spetsificheskikh funktsii u rabotnis neftekhimicheskoi i khimicheskoi promyshlennosti [Industrial hygiene and condition of specific functions of working women in the petrochemical and chemical industry] (R.A. Malysheva, ed.), pp. 149-153. Sverdlovskii Nauchno-Issledovatel'skii Institut Okhrany Materinstva i Mladenchestva Minzdrava RSFSR, Sverdlovsk, USSR.
53. Kronlein, R.U. (1873). Zur Casuistik des Carbolismus acutus [Towards the cause of acute carbolism]. Berl. Klin. Wochenschr. 10: 605-606.
54. Leonardos, G., Kendall, D. and Barnard, N. (1969). Odor threshold determination of 53 odorant chemicals. J. Air Pollut. Control Assoc. 19: 91-95.
55. Leuenberger, C., Ligocki, M.P. and Pankow, J.F. (1985). Trace organic compounds in rain. 4. Identities, concentrations, and scavenging mechanisms for phenols in urban air and rain. Environ. Sci. Techol. 19: 1053-1058.
56. Levan, A. and Tjio, J.H. (1948). Induction of chromosome fragmentation by phenols. Hereditas 34: 453-484.
57. Liao, T.F. and Oehme, F.W. (1981). Tissue distribution and plasma protein binding of [14C] phenol in rats. Toxicol. Appl. Pharmacol. 57: 220-225.
58. Macht, D.I. (1915). An experimental study of lavage in acute carbolic acid poisoning. Bull. Johns Hopkins Hosp. 26: 98-104.
59. Makhinya, A.P. (1972). Data for the sanitary validation of maximum permissible concentrations of sulfur dioxide in combination with phenol. In: American Institute of Crop Ecology Survey of USSR Air Pollution Literature—A Fourth Compilation of Technical Reports on the Biological Effects and the Public Health Aspects of Atmospheric Pollutants (M.Y. Nuttonson ed.), Vol. 17, pp. 6-16. Silver Spring, MD: American Institute of Crop Ecology; report no. AICE-AIR-72-17; APTD-1309. Available from NTIS, Springfield, VA; PB-212599.
60. Miller, J.J., Powell, G.M., Olavesen, A.H. and Curtis, C.G. (1973). The metabolism and toxicity of phenols in cats. Biochem. Soc. Trans. 1: 1163-1165.
61. Miller, J.J., Powell, G.M., Olavesen, A.H. and Curtis, C.G. (1976). The toxicity of dimethoxyphenol and related compounds in the cat. Toxicol. Appl. Pharmacol. 38: 47-57.
62. Minor, J.L. and Becker, B.A. (1971). A comparison of the teratogenic properties of sodium salicylate, sodium benzoate, and phenol. Toxicol. Appl. Pharmacol. 19: 373.
63. Model, A. (1889). Vergiftug mit concentrirter Carbolsaure bei einem diphtheriekranken Kinde. [Poisoning with concentrated phenol in a child suffering from diphtheria]. Ther. Monatshr. 3: 482-485.
64. Morimoto, K., Wolff, S. and Koizumi, A. (1983). Induction of sister-chromatid exchanges in human lymphocytes by microsomal activation of benzene metabolites. Mutat. Res. 119: 355-360.
65. Mukhitov, B. (1964). The effect of low phenol concentrations on the organism of man or animals and their hygienic evaluation. In U.S.S.R. Literature on Air Pollution and Related Occupational Diseases: v. 9 in two parts. (B.S. Levine trans.) Washington, DC: U.S. Department of Commerce, Office of Technical Services; pp. 185-199. Available from NTIS, Springfield, VA; TT-64-11574.
66. Nagel, R., Adler, H.I. and Rao, T.K. (1982). Induction of filamentation by mutagens and carcinogens in a Ion mutant of Escherichia coli. Mutat. Res. 105: 309-312.
67. National Cancer Institute. (1980). Bioassay of phenol for possible carcinogenicity. Bethesda, MD: U.S. Department of Health and Human Services; Technical Report Series No. NCI-CG-TR-203. Available from NTIS, Springfield, VA; PB80-217946.
68. National Institute For Occupational Safety And Health. (1976). Criteria for a recommended standard: Occupational exposure to phenol. Rockville, MD: U.S. Department of Health, Education and Welfare; DHEW publication no. (NIOSH) 76-196. Available from NTIS, Springfield, VA; PB-266495.
69. Oehme, F.W. (1969). Comparative study of the biotransformation and excretion of phenol [dissertation]. Columbia, MO: University of Missouri. Available from University Microfilms, Ann Arbor, MI; publication no. 69-16,097.
70. Ohtsuji, H. and Ikeda, M. (1972). Quantitative relation between atmospheric phenol vapour and phenol in the urine of workers in Bakelite factories. Br. J. Ind. Med. 29: 70-73.
71. Painter, R.B. and Howard, R. (1982). The HeLa DNA-synthesis inhibition test as a rapid screen for mutagenic carcinogens. Mutat. Res. 92: 427-437.
72. Parkhurst, B.R., Bradshaw, A.S., Forte, J.L. and Wright, G.P. (1979). An evaluation of the acute toxicity to aquatic biota of a coal conversion effluent and its major components. Bull. Environ. Contam. Toxicol. 23: 349-356.
73. Paschin, Yu. V., and Bahitova, L.M. (1982). Mutagenicity of benzo(a)pyrene and the antioxidant phenol at the HGPRT locus of V79 Chinese hamster cells. Mutat. Res. 104: 389-393.
74. Petrov, V.I. (1963). Cases of phenol vapor poisoning during coke slaking with phenol water. In USSR Literature on Air Pollution and Related Occupational Diseases—A Survey (B.S. Levine transl.), pp. 219-221. Washington, DC: U.S. Department of Commerce, Office of Technical Services. Available from NTIS, Springfield, VA: 63:11570.
75. Piotrowski, J.K. (1971). Evaluation of exposure to phenol: Absorption of phenol vapor in the lungs and through the skin and excretion of phenol in urine. Br. J. Ind. Med. 28: 172-178.
76. Poirier, M.C., De Cicco, B.T. and Lieberman, M.W. (1975). Nonspecific inhibition of DNA repair synthesis by tumor promoters in human diploid fibroblasts damaged with N-acetoxy-2-acetylaminofluorene. Cancer Res. 35: 1392-1397.
77. Pool, B.L. and Lin, P.Z. (1982). Mutagenicity testing in the Salmonella typhimurium assay of phenolic compounds and phenolic fractions obtained from smokehouse smoke condensates. Food Chem. Toxicol. 20: 383-391.
78. Powell, G.M., Miller, J.J., Olavesen, A.H. and Curtis, C.G. (1974). Liver as a major organ of phenol detoxication. Nature (London) 252: 234-235.
79. Ramli, J.B. and Wheldrake, J.F. (1981). Phenol conjugation in the desert hopping mouse, Notomys alexis. Comp. Biochem. Physiol. C. 69C: 379-381.
80. Rogers, S.C.F., Burrows, D. and Neill, D. (1978). Percutaneous absorption of phenol and methyl alcohol in magenta paint B.P.C. Br. J. Dermatol. 98: 559-560.
81. Salaman, M.H. and Glendenning, O.M. (1957). Tumour promotion in mouse skin by sclerosing agents. Br. J. Cancer 11: 434-444.
82. Sandage, C. (1961). Tolerance criteria for continuous inhalation exposure to toxic material. I. Effects on animals of 90-day exposure to phenol, CCl 4, and a mixture of indole, skatole, H2S, and methyl mercaptan. Wright-Patterson Air Force Base, OH: U.S. Air Force Systems Command, Aeronautical Systems Division; ASD technical report 61-519 (I). Available from NTIS, Springfield, VA; AD-268783.
83. Sollmann, T. (1957). A manual of pharmacology and its applications to therapeutics and toxicology. 8th ed. Philadelphia, PA: W.B. Saunders Co.; pp. 805-809.
84. Spicer, C.W., Riggin, R.M., Holdren, M.W., Deroos, F.L. and Lee, R.N. (1985). Atmospheric reaction products from hazardous air pollutant degradation. Research Triangle Park, NC: U.S. Environmental Protection Agency, Atmospheric Sciences Research Laboratory; EPA report no. EPA-600/3-85-028. Available from NTIS, Springfield, VA; PB85-185841/ XAB.
85. Sri International. (1984). 1984 directory of chemical producers, United States of America. Menlo Park, CA: SRI International; pp. 778-779.
86. Stajduhar-Caric, Z. (1968). Acute phenol poisoning: singular findings in a lethal case. J. Forensic Med. 15: 41-42.
87. Tauber, S. (1985). Studies on detoxication therapy. II. The effect of sulfates and sulfites as well as of sulfur compounds in phenol poisoning. Arch. Exp. Pathol. Pharmakol. 36: 211.
88. Thomas, A.A. and Back, K.C. (1964). A symposium on toxicity in the closed ecologic system, p. 135. Palo Alto, CA: Lockhead Missiles and Space Co.
89. Thurman, C. (1982). Phenol. In: Kirk-Othmer Encyclopedia of Chemical Technology: V-17, Peroxides and Peroxy Compounds, Inorganic to Piping Systems. 3rd ed., pp. 373-384. John Wiley & Sons, New York, NY.
90. Tollens, K. (1905). Uber die Wirkug der Cresole und des Liquor Cresoli saponatus im Vergleich zur Carbolsaure [On the effect of cresols and of liquor crexolis saponatus as compared with phenol]. Arch. Exp. Pathol. Pharmakol. 52: 220-241.
91. U.S. Environmental Protection Agency. (1980). Ambient water quality criteria for phenol. Washington, DC: Criteria and Standards Division; pp. C-24-C-25; EPA report no. EPA-440/ 5-80-066. Available from NTIS, Springfield, VA; PB81-117722.
92. U.S. Environmental Protection Agency. (1983). Treatability manual. Volume I. Treatability data. Washington, DC: Office of Research and Development ; pp. 1.8.1-1 to 1.8.1-6; EPA report no. EPA-600/2-82-001a.
93. U.S. International Trade Commission (1984). Synthetic organic chemicals: United States production and sales, 1983. Washington, DC: U.S. International Trade Commission ; pp. 27-28; USITC publication no. 1588. Available from GPO, Washington, DC; S / N 049-00059-6.
94. Van Duuren, B.L. and Goldschmidt, B.M. (1976). Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis. J. Natl. Cancer Inst. (U.S.) 56: 1237-1242.
95. Van Duuren, B.L., Sivak, A., Langseth, L., Goldschmidt, B.M. and Segal, A. (1968). Initiators and promoters in tobacco carcinogenesis. In: Toward a Less Harmful Cigarette: A Workshop (E. Wynder and D. Hoffman eds.), pp. 173-180. September 1967; New York, NY. Bethesda, MD: U.S. Department of Health, Education, and Welfare; National Cancer Institute (National Cancer Institute Monograph 28).
96. Van Duuren, B.L., Blazej, T., Goldschmidt, B.M., Katz, C., Mel-Chionne, S. and Sivak, A. (1971). Cocarcinogenesis studies on mouse skin and inhibition of tumor induction. J. Natl. Cancer Inst. (U.S.) 46: 1039-1044.
97. Van Duuren, B.L., Katz, C. and Goldschmidt, B.M. (1973). Brief communication: cocarcinogenic agents in tobacco carcinogenesis. J. Natl. Cancer Inst. (U.S.) 51: 703-705.
98. Van Haaften, A.B. and Sie, S.T. (1965). The measurement of phenol in urine by gas chromatography as a check on benzene exposure. Am. Ind. Hyg. Assoc. J. 26: 52-58.
99. Weitering, J.G., Kriggsheld, K.R. and Mulder, G.J. (1979). The availability of inorganic sulphate as a rate-limiting factor in the sulphate conjugation or xenobiotics in the rat? Biochem. Pharmacol. 28: 757-762.
100. Wheldrake, J.F., Baudinette, R.V. and Hewitt, S. (1978). The metabolism of phenol in a desert rodent Notomys alexis. Comp. Biochem. Physiol. C. 61 C: 103-107.
101. Willhard, A. (1886). Examination of the urine in a case of phenol poisoning. Jahresber. Tierchem. 16: 464.
102. Williams, R.T. (1959). Detoxication mechanisms: The metabolism and detoxication of drugs, toxic substances and other organic compounds. 2nd ed. London, United Kingdom: Chapman & Hall.
103. Williams, R.T. (1964). Metabolism of phenolics in animals. In: Biochemistry of phenolic compounds (J.B. Harborne ed.), pp. 205-248. Academic Press Ltd., London, United Kingdom.