Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

Neuroscience Letters

Volumn 79, Issue 1-2, 1987, Pages 195-200

  McGeer, Patrick L ^a   Itagaki, Shigeru ^a   Tago, Hisao ^a   McGeer, Edith G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer's disease; Cholinergic system; Glial fibrillary acidic protein (GFAP); HLA DR; Immune system; Immunohistochemistry; Phagocytosis

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOPROTEIN; HLA DR ANTIGEN;

ALZHEIMER DISEASE; AUTOPSY; CENTRAL NERVOUS SYSTEM; CYTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PHAGOCYTOSIS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBRAL CORTEX; HIPPOCAMPUS; HLA-D ANTIGENS; HLA-DR ANTIGENS; HUMAN; NEUROGLIA; SUPPORT, NON-U.S. GOV'T;

EID: 0023633015     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(87)90696-3     Document Type: Article

References (11)

1. The detailed distribution of MHC class II antigens in normal human organs
2. Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from ‘histologically normal’ to that showing different levels of glial tumor involvement
3. Biochemistry and pathology of the basal ganglia
4. γ-Glutamyltransferase: normal control levels in Alzheimer's disease
5. The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry
6. Microglia
7. Demonstration of HLA-DR antigens in normal human brain
8. Immunofluoresence studies of monocytes in the injured rat brain
9. Interferon-γ induces expression of H-2 and Ia antigens on brain cells