Antiestrogens as treatment of female and male infertilities

Hormone Research in Paediatrics

Volumn 28, Issue 2-4, 1987, Pages 219-229

  Buvat, J ^a   Buvat Herbaut, M ^a   Marcolin, G ^a   Ardaens Boulier, K ^a  

^a Centre d’tude de la Pathologie de I’Appareil Reproducteur et de la Psychosomatique ^*  (France)

Author keywords

Anovulation; Clomiphene; Hormonal effects; Infertility; Luteal phase deficiency; Oligospermia; Tamoxifen

Indexed keywords

CLOMIFENE; TAMOXIFEN;

ANOVULATION; EYE TOXICITY; FEMALE; HOT FLUSH; HUMAN; INFERTILITY; LUTEAL INSUFFICIENCY; MALE; SHORT SURVEY; SPERMATOGENESIS;

ANOVULATION; CLINICAL TRIALS; CLOMIPHENE; COMPARATIVE STUDY; ESTROGEN ANTAGONISTS; FEMALE; HUMAN; INFERTILITY, FEMALE; INFERTILITY, MALE; MALE; OLIGOSPERMIA; RANDOM ALLOCATION; TAMOXIFEN;

EID: 0023632771     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000180947     Document Type: Article

References (30)

1. Adashi, E.Y.: Clomiphene citrate: mechanism(s) and site(s) of action - a hypothesis revisited. Fert. Steril. 42: 331–342 (1984).
2. Helgason, S.; Wilking, N.; Carlstroni, K.; Dambcr, M.G.; Von Schoultz, B.: A comparative study of the estrogenic effects of tamoxifen and 17-beta-estradiol in post-menopausal women. J. clin. En-docr. Metab. 54: 404–408 (1982).
3. Vermeulen, A.; Comhaire, F.: Hormonal effects of an anticstrogen, tamoxifen, in normal and oligo-spermic men. Fert. Steril. 29: 320–324 (1978).
4. Kerin, J.F.; Liu, J.H.; Phillipou, G.; Yen, S.S.C.:Evidence for a hypothalamic site of action of clomiphene citrate in women. J. clin. Endocr. Metab. 61: 265–268 (1985).
5. Tajima, C.: Tamoxifen in the treatment of infertile patients associated with inadequate luteal phase. Fert. Steril. 41: 470–472 (1984).
6. Tajima, C.; Fukushima, T.: Endocrine profiles in tamoxifen-induced ovulatory cycles. Fert. Steril. 40: 23–30 (1983).
7. Winters, S.J.; Troen, P.: Evidence for a role of endogenous estrogen in the hypothalamic control of gonadotropin secretion in men. J. clin. Endocr. Metab. 61: 842–845 (1985).
8. Buvat, J.; Ardaens, K.; Lemaire, A.; Gauthier, A.; Gasnault, J.P.; Buvat-Herbaui, M.: Increased sperm count in 25 cases of idiopathic normogo-nadotropic oligospermia following treatment with tamoxifen. Fert. Steril. 39: 700–703 (1983).
9. Kalla, N.R.; Nisula, B.C.; Menard, R.; Loriaux, D. L.: The effect of estradiol on testicular testosterone biosynthesis. Endocrinology 106: 35–39 (1980).
10. Van Bergeijk, L.; Gooren, L.; Van der Veen, E.A.; De Vries, C.P.: Effects of short- and long-term administration of tamoxifen on hCG-induccd testicular steroidogenesis in man: no evidence for an oestradiol-induced steroidogenic lesion. Int. J. Androl. 8: 28–36 (1986).
11. Smals, A.G.H.; Dony, J.M.J.; Smals, A.E.M.; Pieters, G.F.F.M.; Hermus, A.R.N.N.; Boers, G.H.J.; Benraad, T.J.; Kloppenborg, P.W.C.: Aromatase inhibition by delta-I-testolactone does not relieve the gonadotropin-induced late steroidogenic block in normal men. J. clin. Endocr. Metab. 60: 1127–1131 (1985).
12. Buvat, J.; Buvat-Herbaui, M.: Strategic de reduction de I’ovulation en cas d’anovulation normo-prolactinique; in Buvat. Bringer, Induction et stimulation de I’ovulation. pp. 173–192 (Doin. Paris 1986).
13. Birkenfeld, A.; Navot, D.; Lcvij, S.I.; Laufer, N.; Beier-Hcllwig, K.; Goecke, C.; Schenker, J.G.; Beier, H.M.: Advances secretory changes in the proliferative human endometrial epithelium following clomiphene citrate treatment. Fert. Steril. 45: 462–468 (1986).
14. Yoshimura, Y.; Hosoi, Y.; Atlas, S.J.; Wallach, E. E.: Effect of clomiphene citrate on in vitro ovulated ova. Fert. Steril. 45: 800–804 (1986).
15. Taymor, M.L.: Use and abuse of clomiphene citrate. Fert. Steril. 47: 206–207 (1987).
16. Thomas, D.; L’Hermite, M.: Strategic de la stimulation de I’ovulation en cas de phase luteale inadequate; in Buvat, Bringer, Induction et stimulation de I’ovulation. pp. 219–229 (Doin. Paris 1986).
17. Downs, K.A.; Gibson, M.: Clomiphene citrate therapy for luteal phase defect. Fert. Steril. 39: 34–38 (1983).
18. Witten, B.I.; Martin, S.A.: The endometrial biopsy as a guide to the management of luteal phase defect. Fert. Steril. 44: 460–465 (1985).
19. Fukushima, T.; Tajima, C.; Fukuma, K.; Mayea-ma, M.: Tamoxifen in the treatment of infertility associated with luteal phase deficiency. Fert. Stc-ril. 37: 755–761 (1982).
20. Senior, B.E.; Lawood, M.L.; Oake, R.E.; McKid-die, J.M.; Siddle, D.R.: A comparison of the effects of clomiphene and tamoxifen on the concentrations of estradiol and progesterone in the peripheral plasma of infertile women. Clin. Endocrinol. 8: 381–389 (1978).
21. Roumcn, F.J.M.E.; Doesburg, W.H.; Rolland, R.: Treatment of infertile women with a deficient post-coital test with two antiestrogens: clomiphene and tamoxifen. Fert. Steril. 41: 237–243 (1984).
22. Dony, J.M.: Idiopathic oligospermia. Endocrinological and therapeutical aspects; thesis Nijmegen, pp. 7–8, 74–76 (1985).
23. Vigiersky, R.A.; Glass, A.R.: Effects of delta-1 -testolactone on the pituitary testicular axis in oli-gospermic men. J. clin. Endocr. Metab. 52: 897–900 (1981).
24. Schill, W.B.: Medical treatment of idiopathic nor-mogonadotropic oligospermia. Int. J. Androl. 5: suppl.. pp. 135–153 (1982).
25. Micic, S.; Dotlic, R.: Evaluation of sperm parameters in clinical trial with clomiphene citrate of oligospermic men. J. Urol. 133: 221–222 (1985).
26. Wang, C.; Chan, C.W.; Wong, K.K.; Yeung, K.K.: Comparison of the effectiveness of placebo, clomiphene citrate, mesterolone, pentoxifylline and testosterone rebound therapy in the treatment of idiopathic oligospermia. Fert. Steril. 40: 358–365 (1983).
27. Ronnberg, L.: The effect of clomiphene citrate on different sperm parameters and serum hormone levels in preselected infertile men: a controlled double-blind cross-over study. Int. J. Androl. 3: 479–486 (1980).
28. Comhaire, F.: Treatment of oligospermia with tamoxifen. Int. J. Fertil. 21: 232–238 (1976).
29. Dony, J.M.J.;Smals, A.G.H.; Rolland, R.; Fauser, B.C.J.M.; Thomas, C.M.G.: Effect of lower versus higher doses of tamoxifen on pituitary-gonadal function and sperm indices in oligozoospermic men. Andrologia 17: 369–378 (1985).
30. Baker, H.W.G.; Kovacs, G.T.: Spontaneous improvement in semen quality: regression towards the mean. Int. J. Androl. 8: 421–426 (1985).