Rat brain cathepsin L: Characterization and differentiation from cathepsin B utilizing opioid peptides

Archives of Biochemistry and Biophysics

Volumn 259, Issue 1, 1987, Pages 131-143

  Marks, N ^a   Berg, M J ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; OPIATE PEPTIDE;

ANIMAL CELL; BRAIN; CENTRAL NERVOUS SYSTEM; ENZYME SPECIFICITY; NONHUMAN; PHARMACOKINETICS; RAT;

AMINO ACID SEQUENCE; ANIMAL; BRAIN; CATHEPSIN B; CATHEPSINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDORPHINS; ENKEPHALIN, LEUCINE; KIDNEY; KINETICS; RATS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023627662     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/0003-9861(87)90478-4     Document Type: Article

References (50)

1. Intracellular Protein Catabolism: 6th Symposium
2. Opioid Peptides: Molecular Pharmacology, Biosynthesis, and Analysis
3. Action of cathepsin L on the oxidized B-chain of bovine insulin
4. A general framework of cysteine-proteinase mechanism deduced from studies on enzymes with structurally different analogous catalytic-site residues Asp-158 and -161 (papain and actinidin), Gly-196 (cathepsin B) and Asn-165 (cathepsin H). Kinetic studies up to pH 8 of the hydrolysis of N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide catalysed by cathepsin B and of L-arginine 2-naphthylamide catalysed by cathepsin H.
5. Different immunolocalizations of cathepsins B, H, and L in the liver.