메뉴 건너뛰기




Volumn 12, Issue 4, 1987, Pages 439-464

The expression, localization and functional significance of β-nerve growth factor in the central nervous system

Author keywords

Central nervous system; Cholinergic neuron; Nerve growth factor; NGF mRNA; NGF receptor; NGF behavior; NGF disease

Indexed keywords

NERVE GROWTH FACTOR; CELL SURFACE RECEPTOR; MESSENGER RNA; NERVE GROWTH FACTOR RECEPTOR;

EID: 0023626621     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-0173(87)90008-7     Document Type: Review
Times cited : (438)

References (238)
  • 1
    • 0014173524 scopus 로고
    • The formation of synaptic junctions in developing rat brain: a quantitative electron microscopic study
    • (1967) Brain Res. , vol.6 , pp. 716-727
    • Aghajanian1    Bloom2
  • 5
    • 0019781601 scopus 로고
    • A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism and Alzheimer disease
    • (1981) Ann. Neurol. , vol.10 , pp. 499-505
    • Appel1
  • 8
    • 0017358355 scopus 로고
    • Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia
    • (1977) Acta Neuropathol. (Berlin) , vol.37 , pp. 111-118
    • Ball1
  • 10
  • 13
    • 0018407234 scopus 로고
    • Nerve growth factor in the goldfish brain: biological assay studies using pheochromocytoma cells
    • (1979) Brain Res. , vol.162 , pp. 164-168
    • Benowitz1    Shashoua2
  • 14
    • 0015913953 scopus 로고
    • Nerve growth factor: enhanced recovery of feeding after hypothalamic damage
    • (1973) Science , vol.180 , pp. 506-508
    • Berger1    Wise2    Stein3
  • 15
  • 16
    • 0015842536 scopus 로고
    • Stimulation of growth of new axonal sprouts from lesioned monoamine neurones in adult rat brain by nerve growth factor
    • (1973) Brain Research , vol.60 , pp. 161-176
    • Bjerre1    Björklund2    Stenevi3
  • 17
    • 0016138739 scopus 로고
    • Inhibition of the regenerative growth of central noradrenergic neurons by intracerebrally administered anti-NGF serum
    • (1974) Brain Res. , vol.74 , pp. 1-18
    • Bjerre1    Björklund2    Stenevi3
  • 18
    • 0015513544 scopus 로고
    • Nerve growth factor stimulation of regenerative growth of central noradrenergic neurons
    • (1972) Science , vol.17 , pp. 1251-1253
    • Björklund1    Stenevi2
  • 19
    • 0019825123 scopus 로고
    • In vivo evidence for a hippocampal adrenergic neuronotrophic factor specifically released on septal deafferentation
    • (1981) Brain Res. , vol.229 , pp. 403-428
    • Björklund1    Stenevi2
  • 20
    • 0021922165 scopus 로고
    • Detection of the messenger RNAs coding for the opioid peptide precursors in pituitary and adrenal by ‘in situ’ hybridization: study in several mammal species
    • (1985) Neurosci. Lett. , vol.53 , pp. 141-148
    • Bloch1    LeGuellec2    DeKeyzer3
  • 21
    • 0021261061 scopus 로고
    • Characterization of cholinergic neurons in the rat neostriatum. A combination of choline acetyltransferase immunocytochemistry, Golgi-impregnation and electron microscopy
    • (1984) Neuroscience , vol.12 , pp. 711-718
    • Bolam1    Wainer2    Smith3
  • 23
    • 0021330797 scopus 로고
    • L cells potentiate the effect of the extracellular NGF activity in co-cultures with PC12 pheochromocytoma cells
    • (1984) Exp. Cell Res. , vol.150 , pp. 234-241
    • Brachet1    Dicou2
  • 26
    • 0001228725 scopus 로고
    • Purification and metabolic effects of a nerve growth-promoting protein from snake venom
    • (1959) J Biol Chem , vol.234 , pp. 1129-1135
    • Cohen1
  • 27
    • 0022875838 scopus 로고
    • Cholinergic function and intellectual decline in Alzheimer's disease
    • (1986) Neuroscience , vol.19 , pp. 1-28
    • Collerton1
  • 28
    • 0022406874 scopus 로고
    • Neurotrophic activity in the adult rat hippocampal formation: regional distribution and increase after septal lesion
    • (1985) J. Neurosci. , vol.5 , pp. 2809-2814
    • Collins1    Crutcher2
  • 32
    • 0020686674 scopus 로고
    • Alzheimer's disease: a disorder of cortical cholinergic innervation
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle1    Price2    DeLong3
  • 34
    • 0015692194 scopus 로고
    • A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat
    • (1973) Brain Res. , vol.63 , pp. 195-204
    • Crain1    Cotman2    Taylor3    Lynch4
  • 36
    • 0019418358 scopus 로고
    • Cholinergic denervation of rat neocortex results in sympathetic innervation
    • (1981) Exp. Neurol. , vol.74 , pp. 324-329
    • Crutcher1
  • 38
    • 0020022311 scopus 로고
    • Development of the rat septohippocampal projection: a retrograde fluorescent tracer study
    • (1982) Dev. Brain Res. , vol.3 , pp. 145-150
    • Crutcher1
  • 39
    • 0019509129 scopus 로고
    • Sympathetic noradrenergic sprouting in response to central cholinergic denervation: a histochemical study of neuronal sprouting in the rat hippocampal formation
    • (1981) Brain Res. , vol.210 , pp. 115-128
    • Crutcher1    Brothers2    Davis3
  • 40
    • 0019366466 scopus 로고
    • Sympathohippocampal sprouting is directed by a target trophic factor
    • (1981) Brain Res. , vol.204 , pp. 410-414
    • Crutcher1    Davis2
  • 41
    • 0020042660 scopus 로고
    • Target regulation of sympathetic sprouting in the rat hippocampal formation
    • (1982) Exp. Neurol. , vol.75 , pp. 347-359
    • Crutcher1    Davis2
  • 42
    • 0019950085 scopus 로고
    • In vitro evidence for two distinct hippocampal growth factors: basis of neuronal plasticity?
    • (1982) Science , vol.217 , pp. 67-68
    • Crutcher1    Collins2
  • 43
    • 0022850152 scopus 로고
    • Entorhinal lesions result in increased nerve growth factor-like growth-promoting activity in medium conditioned by hippocampal slices
    • (1986) Brain Res. , vol.399 , pp. 383-389
    • Crutcher1    Collins2
  • 45
    • 84911742917 scopus 로고
    • The anatomy of the CNS cholinergic neurons
    • (1984) TINS , vol.9 , pp. 74-78
    • Cuello1    Sofroniew2
  • 49
    • 0019189573 scopus 로고
    • Failure of nerve growth factor to affect fetal mouse brain stem catecholaminergic neurons in culture
    • (1980) Brain Res. , vol.194 , pp. 540-547
    • Dreyfus1    Peterson2    Crain3
  • 51
    • 0017919154 scopus 로고
    • Retrograde transport of nerve growth factor in the rat central nervous system
    • (1978) Brain Res. , vol.139 , pp. 160-163
    • Ebbott1    Hendry2
  • 57
    • 0021020898 scopus 로고
    • Identification of central cholinergic neurons containing both choline acetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase
    • (1983) J. Neurosci. , vol.3 , pp. 2286-2291
    • Eckenstein1    Sofroniew2
  • 58
    • 0021882017 scopus 로고
    • Neonatal brain damage and recovery: intraventricular injection of NGF at time of injury alters performance of active avoidance
    • (1985) Dev. Brain Res. , vol.19 , pp. 227-235
    • Eclancher1    Ramirez2    Stein3
  • 59
    • 0014749756 scopus 로고
    • Tissue culture assay of nerve growth factor and of the specific antiserum
    • (1970) Exp. Cell Res. , vol.59 , pp. 383-392
    • Fenton1
  • 63
    • 0017178590 scopus 로고
    • The role of nerve growth factor (NGF) in the central nervous system
    • (1976) Brain Res. Bull. , vol.1 , pp. 393-412
    • Freed1
  • 64
    • 0018691832 scopus 로고
    • Seizures and related epileptiform activity in hippocampus transplanted to the anterior chamber of the eye: modulation by cholinergic and adrenergic input
    • (1979) Ann. Neurol. , vol.6 , pp. 281-295
    • Freedman1    Taylor2    Seiger3    Olson4    Hoffer5
  • 65
    • 0022376548 scopus 로고
    • Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study
    • (1985) J. Comp. Neurol. , vol.239 , pp. 237-246
    • Frotscher1    Leranth2
  • 69
    • 0021187871 scopus 로고
    • Denervation releases a neuronal survival factor in adult rat hippocampus
    • (1984) Nature , vol.308 , pp. 637-639
    • Gage1    Björklund2    Stenevi3
  • 70
    • 0022573983 scopus 로고
    • Enhanced graft survival in the hippocampus following selective denervation
    • (1986) Neuroscience , vol.17 , pp. 89-98
    • Gage1    Björklund2
  • 71
    • 0022487150 scopus 로고
    • Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism
    • (1986) J. Neurosci. , vol.6 , pp. 2837-2847
    • Gage1    Björklund2
  • 73
    • 0022480016 scopus 로고
    • Time course of the elevation of nerve growth factor (NGF) content in the hippocampus and septum following lesions of the septohippocampal pathway in rats
    • (1986) Brain Res. , vol.376 , pp. 351-356
    • Gasser1    Weskamp2    Otten3    Dravid4
  • 75
    • 0020565380 scopus 로고
    • NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?
    • (1983) Dev. Brain Res. , vol.9 , pp. 45-52
    • Gnahn1    Hefti2    Heumann3    Schwab4    Thoenen5
  • 76
    • 46149128942 scopus 로고
    • Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: lesion effects in the rat brain and levels in Alzheimer's disease
    • (1986) Mol. Brain Res. , vol.1 , pp. 85-92
    • Goedert1    Fine2    Hunt3    Ullrich4
  • 78
    • 0016276648 scopus 로고
    • A dissociated cell culture bioassay for nerve growth factor
    • (1974) Neurobiology , vol.4 , pp. 286-292
    • Greene1
  • 79
    • 0017724075 scopus 로고
    • A quantitative bioassay for nerve growth factor (NGF) activity employing a clonal pheochromocytoma cell line
    • (1977) Brain Res. , vol.133 , pp. 350-353
    • Greene1
  • 83
    • 0023115225 scopus 로고
    • Nerve growth factor promotes development of the rat septohippocampal cholinergic projection in vitro
    • (1987) Neurosci. Lett. , vol.75 , pp. 6-10
    • Gähwiler1    Enz2    Hefti3
  • 85
    • 0018840290 scopus 로고
    • Nerve growth factor: biological significance, measurement, and distribution
    • (1980) J. Neurochem. , vol.34 , pp. 5-16
    • Harper1    Thoenen2
  • 88
    • 0022543614 scopus 로고
    • Differential effects of nerve-growth factor and glioma-conditioned medium on neurons cultured from various regions of fetal rat central nervous system
    • (1986) Dev. Brain Res. , vol.30 , pp. 47-56
    • Hatanaka1    Tsukui2
  • 89
    • 0022486717 scopus 로고
    • Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transection
    • (1986) J. Neurosci. , vol.6 , pp. 2155-2162
    • Hefti1
  • 90
    • 84911709514 scopus 로고    scopus 로고
    • Hefti, F., Role of nerve growth factor in the CNS. In J. Ferendeli, R. Collins and E. Johnson (Eds.), Neurobiology of Amino Acids, Peptides and Trophic Factors, Martinus Nijhoff, Boston, in press.
  • 91
    • 0021359024 scopus 로고
    • Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions
    • (1984) Brain Res. , vol.293 , pp. 305-311
    • Hefti1    Dravid2    Hartikka3
  • 93
    • 0022481746 scopus 로고
    • Effect of thyroid hormone analogs on the activity of choline acetyltransferase in cultures of dissociated septal cells
    • (1986) Brain Res. , vol.375 , pp. 413-416
    • Hefti1    Hartikka2    Bolger3
  • 96
    • 0015377123 scopus 로고
    • Developmental changes in tissue and plasma concentrations of the biologically active species of nerve growth factor in the mouse, by using a two-site radioimmunoassay
    • (1972) Biochem. J. , vol.128 , pp. 1265-1272
    • Hendry1
  • 97
    • 0021767870 scopus 로고
    • Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues
    • (1984) EMBO J. , vol.3 , pp. 3183-3189
    • Heumann1    Korsching2    Scott3    Thoenen4
  • 99
    • 0020031410 scopus 로고
    • Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregation cell cultures
    • (1982) Dev. Brain Res. , vol.3 , pp. 229-238
    • Honegger1    Lenoir2
  • 102
    • 0021956410 scopus 로고
    • Molecular characteristics of nerve growth factor receptors on PC12 cells
    • (1985) J. Biol. Chem. , vol.260 , pp. 655-662
    • Hosang1    Shooter2
  • 104
    • 0015188767 scopus 로고
    • A sensitive radioimmunoassay for 7S nerve growth factor antigens in serum and tissues
    • (1971) J. Neurochem. , vol.18 , pp. 2355-2362
    • Johnson1    Gorden2    Kopin3
  • 107
  • 109
    • 0013568917 scopus 로고
    • Catecholamine levels and DOPA-decarboxylase activity in peripheral organs and adrenergic tissues in the rat after immunosympathectomy
    • (1965) J. Pharmacol. Exp. Ther. , vol.148 , pp. 14-21
    • Klingman1
  • 110
    • 84911744216 scopus 로고
    • Nerve growth factor (NGF) promotes cell survival and neurite outgrowth of rat CNS neurons in culture. Correlation with ontogenesis of NGF receptor immunoreactivity
    • (1986) Soc. Neurosci. Abstr. , vol.12 , pp. 1093
    • Koh1    Notter2    Loy3
  • 113
  • 117
    • 0023067115 scopus 로고
    • Nerve growth factor treatment after brain injury prevents neuronal death
    • (1987) Science , vol.235 , pp. 214-216
    • Kromer1
  • 118
    • 0022620808 scopus 로고
    • β-Nerve growth factor in developing mouse cerebral cortical synaptosomes: measurement by competitive radioimmunoassay and bioassay
    • (1986) Pediat. Res. , vol.20 , pp. 391-397
    • Lakshmanan1    Weischel2    Tarris3    Fisher4
  • 121
    • 0017271074 scopus 로고
    • The nerve growth factor: its role in growth, differentiation and function of the sympathetic adrenergic neuron
    • (1975) Prog. Brain Res. , vol.45 , pp. 235-258
    • Levi-Montalcini1
  • 125
    • 2042493330 scopus 로고
    • In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo
    • (1954) Cancer Res. , vol.16 , pp. 49-57
    • Levi-Montalcini1    Meyer2    Hamburger3
  • 126
  • 128
    • 0022259889 scopus 로고
    • Temporal expression of mouse glial fibrillary acidic protein mRNA studied by a rapid in situ hybridization procedure
    • (1985) J. Neurochem. , vol.45 , pp. 913-919
    • Lewis1    Cowan2
  • 129
    • 0018666718 scopus 로고
    • Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones
    • (1979) Nature (London) , vol.282 , pp. 80-82
    • Lindsay1
  • 131
    • 0018083739 scopus 로고
    • Synthesis of nerve growth factor in rat glioma cells
    • (1978) Dev. Biol. , vol.65 , pp. 260-270
    • Longo1
  • 132
    • 0017763832 scopus 로고
    • Anomalous innervation of the hippocampal formation by peripheral sympathetic axons following mechanical injury
    • (1977) Exp. Neurol. , vol.57 , pp. 645-650
    • Loy1    Moore2
  • 133
    • 0018859958 scopus 로고
    • Sprouting of sympathetic axons in the hippocampal formation: conditions necessary to elicit ingrowth
    • (1980) Exp. Neurol. , vol.67 , pp. 399-411
    • Loy1    Milner2    Moore3
  • 134
    • 84911733615 scopus 로고
    • Developmental expression of nerve growth factor receptors in sensory systems of the rat CNS
    • (1986) Soc. Neurosci. Abstr. , vol.12 , pp. 393
    • Loy1    Koh2
  • 135
    • 84911709513 scopus 로고    scopus 로고
    • Loy, R., Springer, J.E., Tayrien, M.W. and Koh, S., Septal and lesion-induced sympathetic afferents to the hippocampus are immunoreactive for nerve growth factor receptor, Exp. Neurol., in press.
  • 138
    • 0022871592 scopus 로고
    • Hippocampal pyramidal cells and aging in the human: a quantitative study of neuronal loss in sectors CA1 to CA4
    • (1986) Exp. Neurol. , vol.94 , pp. 29-40
    • Mani1    Lohr2    Jeste3
  • 140
    • 0015993585 scopus 로고
    • Development of cholinergic innervation in the hippocampal formation of the rat. I. Histochemical demonstration of acetylcholinesterase activity
    • (1974) Dev. Biol. , vol.36 , pp. 130-141
    • Matthews1    Nadler2    Lynch3    Cotman4
  • 141
    • 0022746538 scopus 로고
    • Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF
    • (1986) EMBO J. , vol.5 , pp. 1489-1493
    • Meier1    Becker-Andre2    Götz3    Heumann4    Shaw5    Thoenen6
  • 142
  • 143
    • 0021270569 scopus 로고
    • Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry
    • (1984) Neuroscience , vol.12 , pp. 669-686
    • Mesulam1    Mufson2    Levey3    Wainer4
  • 144
    • 0020771410 scopus 로고
    • An anatomical study of the development of the septo-hippocampal projection in the rat
    • (1983) Dev. Brain Res. , vol.8 , pp. 343-371
    • Milner1    Loy2    Amaral3
  • 150
    • 0000026363 scopus 로고
    • An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunohistochemistry
    • A. Björklund, T. Hökfelt, Handbook of Chemical Neuroanatomy, Elsevier, Amsterdam, Part I
    • (1985) GABA and Neuropeptides in the CNS , vol.4 , pp. 436-608
    • Mugnaini1    Oertel2
  • 153
    • 0015951780 scopus 로고
    • Development of cholinergic innervation in the hippocampal formation of the rat. Quantitative changes in choline acetyltransferase and acetylcholinesterase activities
    • (1974) Dev. Biol. , vol.36 , pp. 142-154
    • Nadler1    Matthews2    Cotman3    Lynch4
  • 154
    • 0017231824 scopus 로고
    • Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents
    • (1976) Nature , vol.11 , pp. 538-540
    • Nadler1    Vaca2    White3    Lynch4    Cotman5
  • 159
    • 0018593093 scopus 로고
    • NGF and antiNGF: evidence against effects of fiber growth in locus coeruleus from cultures of perinatal CNS tissues
    • (1979) Dev. Neurosci. , vol.2 , pp. 160-176
    • Olson1    Ebendal2    Seiger3
  • 161
    • 0023036744 scopus 로고
    • Longterm effects of nerve growth factor and neural transplants on behavior of rats with medial septal lesions
    • (1986) Brain Res. , vol.386 , pp. 197-208
    • Pallage1    Toniolo2    Will3    Hefti4
  • 163
    • 0015153916 scopus 로고
    • Effects of a nerve-growth factor, embryo age and metabolic inhibitors on growth of fibers and on synthesis of ribonucleic acid and protein in embryonic sympathetic ganglia
    • (1971) J. Neurochem. , vol.18 , pp. 2101-2118
    • Partlow1    Larrabee2
  • 164
    • 0018374305 scopus 로고
    • Nerve growth factor: intense polydipsia of long duration produced by ventral diencephalic application
    • (1979) Brain Res. , vol.161 , pp. 351-355
    • Perkins1    Margules2    Ward3
  • 165
    • 0020577422 scopus 로고
    • Sprouting of sympathetic fibers in the hippocampus in the absence of major target cell candidates
    • (1983) Brain Res. , vol.264 , pp. 21-29
    • Peterson1    Loy2
  • 174
    • 0021959647 scopus 로고
    • Evidence for a ‘perivascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
    • (1985) Brain Res. , vol.326 , pp. 47-63
    • Rennels1    Gregory2    Blaumanis3    Fujimoto4    Grady5
  • 177
    • 0021645710 scopus 로고
    • Immunohistochemical localization of endogenous nerve growth factor
    • (1984) Nature (London) , vol.312 , pp. 364-367
    • Rush1
  • 178
    • 0021238760 scopus 로고
    • Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex
    • (1984) Science , vol.225 , pp. 947-949
    • Sajdel-Sulkowska1    Marotta2
  • 181
    • 0019501554 scopus 로고
    • Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association
    • (1981) Cell , vol.24 , pp. 867-874
    • Schechter1    Bothwell2
  • 182
    • 0021714371 scopus 로고
    • Enhancement of central cholinergic sprouting by prior injury: correlation with endogenous trophic content of hippocampus
    • (1984) Brain Res. , vol.321 , pp. 377-380
    • Schonfeld1    Heacock2    Katzman3
  • 183
    • 0017133442 scopus 로고
    • Immunocytochemical localization of nerve growth factor (NGF) in the submandibular gland of adult mice by light and electron microscopy
    • (1976) Cell Tissue Res. , vol.169 , pp. 289-299
    • Schwab1    Stöckel2    Thoenen3
  • 184
    • 0018367557 scopus 로고
    • Nerve growth factor (NGF) in the rat CNS: absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra
    • (1979) Brain Res. , vol.168 , pp. 473-483
    • Schwab1    Otten2    Agid3    Thoenen4
  • 187
    • 0017727664 scopus 로고
    • Reinitiation of directed nerve fiber growth in central monoamine neurons after intraocular maturation
    • (1977) Exp. Brain Res. , vol.29 , pp. 15-44
    • Seiger1    Olson2
  • 188
    • 0021257975 scopus 로고
    • Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat
    • (1984) Brain Res. , vol.300 , pp. 33-39
    • Seiler1    Schwab2
  • 189
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • (1986) Cell , vol.46 , pp. 559-667
    • Shaw1    Kamen2
  • 191
    • 0022503081 scopus 로고
    • Studies on the regulation of beta-nerve growth factor gene expression in the rat iris: the level of mRNA-encoding nerve growth factor is increased in irises placed in expiant cultures in vitro, but not in irises deprived of sensory or sympathetic innervation in vivo
    • (1986) J. Cell Biol. , vol.102 , pp. 1940-1948
    • Shelton1    Reichardt2
  • 192
    • 0000901144 scopus 로고
    • Studies on the expression of the β nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 2714-2718
    • Shelton1    Reichardt2
  • 195
    • 0022245591 scopus 로고
    • Detection of preprocholecystokinin and preproenkephalin A mRNAs in rat brain by hybridization histochemistry using complementary RNA probes
    • (1986) Neuropeptides , vol.6 , pp. 573-580
    • Siegal1    Young2
  • 196
    • 0017849848 scopus 로고
    • Possible biochemical basis of memory disorder in Alzheimer's disease
    • (1978) Ann. Neurol. , vol.3 , pp. 471-473
    • Smith1    Swash2
  • 197
    • 0022319605 scopus 로고
    • Intrahippocampal injections of antiserum to nerve growth factor inhibit sympathohippocampal sprouting
    • (1985) Brain Res. Bull. , vol.15 , pp. 629-634
    • Springer1    Loy2
  • 198
    • 0023099778 scopus 로고
    • Basal forebrain magnocellular neurons stain for nerve growth factor: correlation with cholinergic cell bodies and effects of axotomy
    • (1987) J. Neurosci. Res. , vol.17 , pp. 111-118
    • Springer1    Koh2    Tayrien3    Loy4
  • 199
    • 0019154804 scopus 로고
    • Nerve growth factor disrupts metabolism and behavioral performance of intact rats but does not affect recovery from hypothalamic lesions
    • (1980) Brain Res. , vol.190 , pp. 278-284
    • Stein1    Blake2    Weiner3
  • 200
    • 0020692431 scopus 로고
    • Nerve growth factor produces a temporary facilitation of recovery from entorhinal cortex lesions
    • (1983) Brain Res. , vol.261 , pp. 127-131
    • Stein1    Will2
  • 202
    • 0017890514 scopus 로고
    • Growth of vascular sympathetic axons into the hippocampus after lesions of the septo-hippocampal pathway: a pitfall in brain lesion studies
    • (1978) Neurosci. Lett. , vol.7 , pp. 219-224
    • Stenevi1    Björklund2
  • 203
    • 0017614742 scopus 로고
    • Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy
    • (1977) Brain Res. , vol.120 , pp. 379-386
    • Storm-Mathisen1
  • 207
  • 210
    • 25044433664 scopus 로고
    • Immunocytochemical localization of nerve growth factor (NGF) and NGF receptor in the rat olfactory bulb
    • (1986) Anat. Rec. , vol.214 , pp. 133A
    • Tayrien1    Koh2    Springer3    Loy4
  • 213
    • 0022500985 scopus 로고
    • The neurobiology of learning and memory
    • (1986) Science , vol.233 , pp. 941-947
    • Thompson1
  • 214
    • 0022385362 scopus 로고
    • Acetylcholine rich transplants in the hippocampus: influence of intrinsic growth factors and application of nerve growth factor on choline acetyltransferase activity
    • (1985) Brain Res. , vol.345 , pp. 141-146
    • Toniolo1    Dunnett2    Hefti3    Will4
  • 215
    • 0021826829 scopus 로고
    • Vasopressin mRNA in situ hybridization, localization and regulation studied with oligonucleotide cDNA probes in normal and Brattleboro rat hypothalamus
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 5555-5559
    • Uhl1    Zingg2    Habener3
  • 219
  • 221
    • 0019947184 scopus 로고
    • Ontogenesis of nerve growth factor and epidermal growth factor in submaxillary glands and nerve growth factor in brains of immature male mice: correlation with ontogenesis of serum levels of thyroid hormones
    • (1982) Pediat. Res. , vol.16 , pp. 520-524
    • Walker1    Weichsel2    Eveleth3    Fisher4
  • 226
    • 84911709511 scopus 로고    scopus 로고
    • Whittemore, S.R., Persson, H., Ebendal, T., Lärkfors, L., Larhammar, D. and Ericsson, A., The structure and expression of NGF in the rat CNS. In A. Gorio, J. deVellis J.R. Perez-Polo and B. Haber (Eds.), Cellular and Molecular Aspects of Neural Development and Regeneration, Springer, Heidelberg, in press.
  • 227
    • 0022245786 scopus 로고
    • Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions
    • (1985) Behav. Brain Res. , vol.17 , pp. 17-24
    • Will1    Hefti2
  • 231
    • 0023191469 scopus 로고
    • A quantitative study of the developmental expression of nerve growth factor (NGF) receptor in rats
    • (1987) Dev. Biol. , vol.121 , pp. 139-148
    • Yan1    Johnson2
  • 234
    • 0023258058 scopus 로고
    • Noradrenergic, serotinergic, and cholinergic sprouting in the hippocampus that follows partial or complete transection of the sept ohippocampal pathway: contributions of spared inputs
    • (1987) Exp. Neurol. , vol.96 , pp. 352-364
    • Gasser1    Dravid2
  • 236
  • 237
    • 84911709510 scopus 로고    scopus 로고
    • Lärkfors, L., Ebendal, T., Whittemore, S.R., Persson, H., Hoffer, B. and Olson, L., Decreased levels of nerve growth factor and its messenger RNA in the aged rat brain, Mol. Brain Res., in press.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.