Studies on the mode of vasodilating action of carvedilol

Journal of Cardiovascular Pharmacology

Volumn 10, Issue , 1987, Pages S42-S48

  Sponer, G ^a   Strein, K ^a   Muller Beckmann B ^a   Bartsch, W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Carvedilol; Experimental models; Vasodilatation; blockade; stimulation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CARVEDILOL; CLONIDINE; DIHYDRALAZINE; KETANSERIN; LABETALOL; METHOXAMINE; NITROPRUSSIDE SODIUM; NORADRENALIN; PHENTOLAMINE; POTASSIUM CHLORIDE; PRAZOSIN; PROPRANOLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; BIOLOGICAL MODEL; BLOOD PRESSURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; VASODILATATION;

ANIMAL; AORTA; CARBAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; IN VITRO; LABETALOL; MUSCLE RELAXATION; NITROPRUSSIDE; NOREPINEPHRINE; PROPANOLAMINES; RATS; RATS, INBRED STRAINS; VASODILATION; VASODILATOR AGENTS;

EID: 0023621018     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/00005344-198710111-00007     Document Type: Article

References (17)

1. Sponer G. Bartsch W, Strein K, Müller-Beckmann B, Böhm E. Pharmacological profile of carvedilol as a β-blocking agent with vasodilating and hypotensive properties. J Cardiovasc Pharmacol 1987;9:317-27.
2. Strein K, Sponer G. Müller-Beckmann B, Bartsch W. Pharmacological profile of carvedilol. a compound with β-blocking and vasodilating properties. J Cardiovasc Pharmacol 1987;10(suppl 11):S33-S41.
3. Meyer-Sabellek WA, Schulte KL, Thiede HM, Gotzen R. Acute hypotensive response to the new antihypertensive agent BM 14.190 in essential hypertensive patients. J Hypertension 1983;l(suppl 2):351-2.
4. Eggertsen R, Sivertsson R, Andren L, Hansson L. Haemo-dynamic effects of carvedilol, a new beta-adrenoceptor blocker and precapillary vasodilator in essential hypertension. J Hypertension 1984;2:529-34.
5. Graham RM, Thornell IR, Gain JM, Bagnoli C, Oates HF, Stokes GS. Prazosin: the first-dose phenomenon. Brit Med J 1976;2:1293-4.
6. Furchgott RF, Bhadrakom S. Reaction of strips of rabbit aorta to epinephrine, isoproterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther 1953;108:129-43.
7. Massingham R. A study of compounds which inhibit vascular smooth muscle contraction. Eur J Pharmacol 1973; 22:75-82.
8. Kent RL, Harakal C, Santamore WP, Carey RA, Bove AA. An index for comparing the inhibitory action of vasodilators. Eur J Pharmacol 1982;85:85-91.
9. Shipley RE, Tilden JH. A pithed rat preparation suitable for assaying pressor substances. Proc Soc Exp Biol Med 1947; 64:453-5.
10. Ignarro LJ, Lippton H, Edwards JC, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981;218:739-49.
11. Farmer JB, Kennedy I, Levy GP, Marshall RJ. Pharmacology of AH 5158; a drug which blocks both alpha and β-adrenoceptors. Br J Pharmacol 1972;45:660-75.
12. Brittain RT, Levy GP. A review of the animal pharmacology of labetalol, a combined alpha- and β-adrenoceptor-blocking drug. Br J Pharmacol 1982;3:681-94.
13. Baum T, Sybertz EJ. Pharmacology of labetalol in experimental animals. Am J Med 1983;75(suppl 10): 15-23.
14. Schölkens BA, Xiang J, Jung W. Effects of the converting enzyme inhibitor HOE 498 on vascular responses to norepinephrine. Z Kardiol 1985;74(suppl 3): 102.
15. Tell GPE, Cuatrecasas P. Beta-adrenergic receptors: Stereo-specificity and lack of affinity for catechols. Biochem Biophys Res Commun 1974;57:793-800.
16. Takenaka T, Honda K, Osawa A, Matsuda Y. Preliminary cardiovascular studies with BM 14.190. Report D 18, Boehringer Mannheim, 1982.
17. Bartsch W, Sponer G, Strein K, Böhm E, Hooper RG. Evaluation of risk for drug-induced postural hypotension in an experimental model: Investigations with carvedilol, prazosin, labetalol, and guanethidine. J Cardiovasc Pharmacol 1987;10(suppl 11):S49-S51.