Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets

Journal of Cardiovascular Pharmacology

Volumn 10, Issue , 1987, Pages S96-S98

  Wood, Jeanette M ^a   Baum, Hans Peter ^a   Jobber, Ross A ^a   Neisius, Dietmar ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Immunoreactive renin; Plasma renin activity; Primate; Renin inhibition; Renin release; Sodium depletion

Indexed keywords

FUROSEMIDE; N BENZYLOXYCARBONYLARGINYLARGINYLPROLYLPHENYLALANYLHISTIDYLSTATINYLISOLEUCYLHISTIDYL (NEPSILON BUTYLOXYCARBONYLLYSINE) METHYL ESTER;

ANIMAL EXPERIMENT; BLOOD PRESSURE; FEMALE; HEART RATE; IMMUNOREACTIVITY; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MONKEY; NONHUMAN; OSMOTIC MINIPUMP; PLASMA RENIN ACTIVITY; SODIUM DEPLETION;

ANIMAL; BLOOD PRESSURE; CALLITHRIX; DIET, SODIUM-RESTRICTED; FEMALE; HEART RATE; MALE; OLIGOPEPTIDES; RENIN;

EID: 0023609891     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/00005344-198706107-00017     Document Type: Article

References (7)

1. Leekie B, Szelke M, Hallett A, et al. Peptide inhibitors of renin. Clin Exp Hypertension A 1983;5:1221-36.
2. Wood JM, Stanton JL, Hofbauer KG. Inhibitors of renin as potential therapeutie agents. J Enzyme Inhibition 1987;1:169-85.
3. Wood JM, Gulati N, Korgiarini P, Ftihrer W, Hofbauer KG. Effects of a specific and long-acting renin inhibitor in the marmoset. Hypertension 1985;7:797-803.
4. Hotbauer KG, Wood JM, Gulati N, Heusser C, Ménard J. Increased plasma renin during renin inhibition: studies with a novel immunoassay. Hypertension 1985;7:(suppl 1):E61-E65.
5. Zimmerman BG, Sybertz GJ, Wong PC. Interaction between sympathetic and renin-angiotensin system. J. Hypertension 1984;2:581-7.
6. Re RN. Cellular biology of the renin-angiotensin systems. Areh Intern Med 1984;144:2037-41.
7. Potter EK. Angiotensin inhibits action of vagus nerve at the heart. Br J Pharmacol 1983;75:9-11.