Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

Antiviral Research

Volumn 8, Issue 5-6, 1987, Pages 261-272

  Clercq, Erik De ^a   Sakuma, Takashi ^a   Baba, Masanori ^a   Pauwels, Rudi ^a   Balzarini, Jan ^a   Rosenberg, Ivan ^b   Holý, Antonin ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

(S) HPMPA; (S) HPMPC; Adenovirus; Cytomegalovirus; Herpes simplex virus; Phosphonylmethoxyalkylpurines; Phosphonylmethoxyalkylpyrimidines; PMEA; Varicellazoster virus

Indexed keywords

ADENOVIRUS; CELL CULTURE; CYTOMEGALOVIRUS; HERPES SIMPLEX VIRUS; NONHUMAN; PRIORITY JOURNAL; VARICELLA ZOSTER VIRUS;

ANIMAL; ANTIVIRAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; DNA VIRUSES; DRUG EVALUATION, PRECLINICAL; HUMAN; MICE; ORGANOPHOSPHORUS COMPOUNDS; PURINES; PYRIMIDINES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; VIRUS DISEASES;

EID: 0023607245     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(87)80004-9     Document Type: Article

References (19)

1. Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl(adenine and 2′-nor-cyclic GMP on adenovirus replication in vitro
2. In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against newly isolated clinical varicella-zoster virus strains
3. Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2′-deoxyuridine and related compounds
4. Antiviral nucleoside analogs
5. −) mutants of herpes simplex virus. Therapeutic approaches
6. Effect of interferon. polyacrylic acid, and polymethacrylic acid on tail lesions in mice infected with vaccinia virus
7. Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2′-deoxyuridine, against herpes simplex virus
8. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus
9. A novel selective broad-spectrum anti-DNA virus agent
10. Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro
11. Synthesis of 9-(2-phosphonylmethoxyethyl)adenine and related compounds
12. Synthesis of isomeric and enantiomeric O-phosphonylmethyl derivatives of 9-(2,3-dihydroxypropyl)adenine
13. Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication
14. Efficacy of (S)-HPMPA against thymidine kinase-deficient herpes simplex virus-keratitis
15. Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus
16. Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro
17. Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus
18. Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease
19. Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis