Clonidine displacing substance is biologically active on smooth muscle

European Journal of Pharmacology

Volumn 142, Issue 3, 1987, Pages 453-455

  Felsen, Diane ^a   Ernsberger, Paul ^a   Meeley, Mary P ^a   Reis, Donald J ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Clonidine; Clonidine displacing substance; Gastric fundus; Smooth muscle contraction

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ANGIOTENSIN II [1 SARCOSINE 8 ALANINE]; APRACLONIDINE; ATROPINE; BRADYKININ DERIVATIVE; CLONIDINE DISPLACING SUBSTANCE; METHYSERGIDE; PHENOXYBENZAMINE; PROSTAGLANDIN E2; VASOPRESSIN DERIVATIVE;

ANIMAL CELL; AORTA; DOG; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; ILEUM; JEJUNUM; NONHUMAN; RABBIT; RAT; SAPHENOUS VEIN; SMOOTH MUSCLE CONTRACTILITY; STOMACH FUNDUS;

ANIMAL; CATTLE; CLONIDINE; DINOPROSTONE; DOGS; IN VITRO; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; PROSTAGLANDINS E; RABBITS; RADIOIMMUNOASSAY; RATS; SUPPORT, NON-U.S. GOV'T; TISSUE EXTRACTS;

EID: 0023604870     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(87)90087-2     Document Type: Article

References (9)

1. Isolation of an endogenous clonidine-displacing substance from rat brain
2. An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure
3. 2 receptors in serotonin-induced contractions of nonvascular smooth muscle, J. Pharmacol. Exp. Ther. 232, 770.
4. An endogenous brain substance, CDS (clonidine-displacing substance), inhibits the twitch response of rat vas deferens
5. 3H-para-aminoclonidine
6. Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity
7. An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla
8. A sensitive method for the assay of 5-hydroxytryptamine
9. Platelet activating factor is a potent stimulus for renal prostaglandin release: Possible significance in unilateral ureteral obstruction