Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA

Biochimie

Volumn 69, Issue 8, 1987, Pages 879-884

  Moazed, Danesh ^a   Noller, Harry F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antibiotics; chemical probing; peptidyl transferase; ribosomal RNA

Indexed keywords

CARBOMYCIN; CHLORAMPHENICOL; ERYTHROMYCIN; PEPTIDYLTRANSFERASE; RIBOSOME RNA; UNCLASSIFIED DRUG; VERNAMYCIN;

DRUG MECHANISM; ESCHERICHIA COLI; NONHUMAN;

ACYLTRANSFERASES; ANTIBIOTICS; AUTORADIOGRAPHY; BASE SEQUENCE; CHLORAMPHENICOL; ERYTHROMYCIN; ESCHERICHIA COLI; LEUCOMYCINS; NUCLEIC ACID CONFORMATION; PEPTIDYLTRANSFERASE; RNA, RIBOSOMAL; RNA, RIBOSOMAL, 23S; SUPPORT, U.S. GOV'T, P.H.S.; VIRGINIAMYCIN;

EID: 0023604799     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/0300-9084(87)90215-X     Document Type: Article

References (21)

1. Substrate-and Antibiotic-Binding Sites at the Peptidyl-Transferase Centre of Escherichia coli Ribosomes. Studies on the Chloramphenicol, Lincomycin and Erythromycin Sites