A double-blind clinical trial of prophylactic cloxacillin in open fractures

Journal of Orthopaedic Trauma

Volumn 1, Issue 1, 1987, Pages 12-17

  Braun, R ^a,b   Enzler, M A ^c   Rittmann, W W ^c  

^a Foundation Norbert Metz ^*  (Luxembourg)

^b UNIVERSITY OF BASEL   (Switzerland)

^c Chirurgische Klinik Stadtspital Waid   (Switzerland)

Author keywords

Antibiotics; Cloxacillin; Infection; Open fracture; Osteitis; Prophylaxis

Indexed keywords

CLOXACILLIN; PLACEBO;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIAL INFECTION; CLINICAL TRIAL; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INJURY; ISOLATION AND PURIFICATION; LIMB; MALE; MICROBIOLOGY; OPEN FRACTURE; OSTEOSYNTHESIS; PREMEDICATION; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL INFECTIONS; CLINICAL TRIALS; CLOXACILLIN; COMPARATIVE STUDY; DOUBLE-BLIND METHOD; EXTREMITIES; FEMALE; FRACTURE FIXATION, INTERNAL; FRACTURES, OPEN; HUMAN; MALE; MIDDLE AGE; PLACEBOS; PREMEDICATION; RANDOM ALLOCATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 0023587027     PISSN: 08905339     EISSN: 15312291     Source Type: Journal    
DOI: 10.1097/00005131-198701010-00002     Document Type: Article

References (15)

1. Bergmann BR: Antibiotic prophylaxis in open and closed fractures: a controlled clinical trial. Acta Orthop Scand 53:57, 1982
2. Bowers WH, Wilson FC, Greene WB: Antibiotic prophylaxis in experimental bone infections. J Bone Joint Surg 55A:795, 1973
3. Boyd RJ, Burke JF, Colton T: A double-blind clinical trial of prophylactic antibiotics in hip fractures. J Bone Joint Surg 55A:1251, 1973
4. Burnett JW, Gustilo RB, Williams DN, Kind AC: Prophylactic antibiotics in hip fractures. J Bone Joint Surg 62A:457, 1980
5. Burke JF: Preventing bacterial infection by coordinating antibiotic and cost activity: A time dependent relationship. South Med J 70:24, 1977
6. Chapman MW, Mahoney M: The role of early internal fixation in the management of open fractures. Clin Orthop 138:120, 1979
7. Ericson C, Lindgren L, Lindberg L: Cloxacillin in the prophylaxis of post-operative infections of the hip. J Bone Joint Surg 55:808, 1973
8. Gatell J, Riba J, Lozano LM, Maña J, Ramon R, Sanmiguel JG: Prophylactic cefamandole in orthopaedic surgery. J Bone Joint Surg 66A:1219, 1984
9. Matter P, Rittmann WW: The open fracture. Hans Huber, Bern, 1973
10. Patzakis MJ, Harvey JP, Ivler D: The role of antibiotics in the management of open fractures. J Bone Joint Surg 56:532, 1974
11. Rittmann WW, Perren SM: Cortical bone healing after internal fixation and infection. In: Biomechanics and Biology. Springer, New York, 1974
12. Mindermann T, Gruber UF: Indikationen zur Einmaldosis-Antibiotika-prophylaxe in Chirurgie und Gynäkologie. Hans Huber, Bern, 1984
13. Rittmann WW, Schibli M, Matter P, Allgöwer M: Open fractures. Long-term results in 200 consecutive cases. Clin Orth of Rel Res 138:132, 1979
14. Stone HH, et al: Prophylactic and preventive antibiotic therapy: Timing, duration and economics. Ann Surg 189:661, 1979
15. Roth AJ, Fry DE, Polk HC: Infectious morbidity in extremity fractures. J Trauma 26:757, 1986