Carrier mediated transport of amino acids, small peptides, and their drug analogs

Journal of Controlled Release

Volumn 6, Issue 1, 1987, Pages 115-121

  Sinko, Patrick J ^a   Ming Hu, ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CEFATRIZINE; LEVODOPA; METHYLDOPA; PEPTIDE;

ANIMAL EXPERIMENT; DRUG ABSORPTION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

EID: 0023571669     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(87)90069-1     Document Type: Article

References (24)

1. Measurements of intestinal permeability using lw molecular weight polyethylene glycols (PEG 400). I. Chemical analysis and biological properties of PEG 400
2. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals
3. Passage of molecules through the wall of the gastrointestinal tract; measurement of intestinal permeability to polyethylene glycols in the 634–1338 dalton range (PEG 1000)
4. Binding of antibiotics to rat intestinal mucin
5. Absorption ofamino acids
6. Absorption of protein digestion products
7. Peptide absorption and hydrolysis
8. Mucosal and serosal fluxes of alanine in rabbit ileum
9. Characteristics of the amino acid transport system in the mucosal border of rabbit ileum
10. Concentration and pH dependency of α-methyldopa absorption in rat intestine
11. 14C-labelled α-methyldopa in normal and hypertensive human subjects
12. Cephalexin penetration of the surviving rat intestine
13. Characterization of aminocephalosporin transport across rat small intestine
14. Carrier mediated transport systems for aminopenicillins in rat small intestine
15. Intestinal absorption mechanism of amino-β-lactam antibiotics. III. Kinetics of carrier-mediated transport across the rat small intestine in situ
16. Structure affinity relationships of substrates for the neutral amino acid transport system in rabbit ileum
17. Studies on a wide spectrum intestinal dipeptide uptake system in the monkey and in the human
18. Influx of two dipeptides, glycylsarcosine and l-glutamic acid, into hamster jejunum in vitro
19. Influx of glycylsarcosine and l-lysyl-l-lysine into hamster jejunum in vitro
20. Intestinal absorption of peptides
21. Intestinal transport of dipeptides in man: Relative importance of hydrolysis and intact absorption