Antimalarial Activity of 2-(Substituted amino)-4,6-bis(trichloromethyl)-l,3,5-triazines and N-(Chlorophenyl)-N′-[4-(substituted amino)-6-(trichloromethyl)-l,3,5-triazin-2-yl]guanidines

Journal of Medicinal Chemistry

Volumn 30, Issue 11, 1987, Pages 1943-1948

  Werbel, Leslie M ^a   Elslager, Edward F ^a   Hess, Carolyn ^a   Hutt, Marland P ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANIDINE DERIVATIVE; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; DRUG SCREENING; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM GALLINACEUM; PROTOZOON; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIMALARIALS; GUANIDINES; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, NON-P.H.S.; TRIAZINES;

EID: 0023568289     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00394a002     Document Type: Article

References (22)

1. This is paper 64 of a series on antimalarial drugs. For paper 63, see: Werbel, L. M.; Degnan, M. J. J. Med. Chem. 1987, 30, 2151.
2. This investigation was supported in U. S. Army Medical Research and Development Command Contract DA-49-193-MD-2754. This is Contribution No. 1815 to the U. S. Army Drug Development Program.
3. Jacobus, D. P. Presented before the Division of Medicinal Chemistry at the 153rd National Meeting of the American Chemical Society. Miami Beach. FL. April 1967.
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16. The parenteral antimalarial screening was carried out by Dr. Leo Rane of the University of Miami, and test results were provided through the courtesy of Dr. David P. Jacobus, Dr. T. R. Sweeney, and Dr. E. A. Steck of the Walter Reed Army Institute of Research. For a description of the test method, see ref 17.
17. Osdene, T. S.; Russell, P. B.; Rane, L. J. Med. Chem. 1967,10, 431.
18. Oral antimalarial screening against P. berghei in mice was carried out by Dr. Paul E. Thompson and co-workers, Department of Pharmacology, Parke, Davis and Co., Ann Arbor, MI. For a description of the test method, see ref 19 and 20.
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21. Antimalarial screening against P. Gallinaceum in chicks was carried out by Dr. Leo Rane at the University of Miami, and test results were supplied through the courtesy of Dr. David P. Jacobus, Dr. T. R. Sweeney, and Dr. E. A. Steck of the Walter Reed Army Institute of Research.
22. Bent, R. L.; et al. J. Am. Chem. Soc. 1951, 73, 3100.