Antitumor Activity of 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a Novel Water-Soluble Derivative of Camptothecin, against Murine Tumors

Cancer Research

Volumn 47, Issue 22, 1987, Pages 5944-5947

  Kunimoto, Takehiko ^a   Nitta, Kazuo ^a   Tanaka, Tomiko ^a   Uehara, Nobuaki ^a   Baba, Hiroyasu ^a   Takeuchi, Mieko ^a   Yokokura, Teruo ^b   Sawada, Siego ^b   Miyasaka, Tadashi ^c   Mutai, Masahiko ^b  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^c SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN DERIVATIVE; DOXORUBICIN; IRINOTECAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; DRUG SENSITIVITY; LEUKEMIA L 1210; LEWIS CARCINOMA; NONHUMAN;

ANIMAL; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED STRAINS; NEOPLASMS, EXPERIMENTAL; SUPPORT, NON-U.S. GOV'T;

EID: 0023552964     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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2. Muggia, F. M., Creaven, P. J., Hansen, H. H., Cohen, M. H., and Selawry, O. S. Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880); correlation with preclinical studies. Cancer Chemother. Rep., 56:515-521, 1972.
3. Schaeppi, U., Fleischman, R. W., and Cooney, D. A. Toxicity of camptothecin (NSC-100880). Cancer Chemother. Rep. Part 3,5; 25-36,1974.
4. Wall, M. E., and Wani, M. C. Camptothecin. In: J. M. Cassadry and J. D. Duros (eds.), Anticancer Agents Based on Natural Product Models, pp. 417–437. New York: Academic Press, Inc., 1980.
5. Kunimoto, T., Nitta, K., Tanaka, T., Uehara, N., Baba, H., Takeuchi, M., Yokokura T., Sawada, S., Miyasaka, T., and Mutai, M. Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors. J. Pharmacobiodyn., 10:149-152, 1987.
6. Nitta, K., Yokokura, T., Sawada, S., Takeuchi, M., Tanaka, T., Uehara, N., Baba, H., Kunimoto, T., Miyasaka, T., and Mutai, M. Antitumor activity of a new derivative of camptothecin. In: Recent Advances in Chemotherapy (Proc. 14th Int. Cong. Chemother.), pp. 28–30. Tokyo: University of Tokyo Press, 1985.
7. Geran, R. I., Greenberg, N. H., Macdonald, M. M., Schumacher, A. M., and Abbott, B. J. Protocols for screening chemical agents and natural products against animal tumors and other biological systems, (ed. 3). Cancer Chemother. Rep. Part 3,3:1-103,1972.
8. Matsuzono, H. Japan Patent; Kokai, 56-158786,1981.
9. Miyasaka, T., Sawada, S., Nokata, K., Sugino, E., and Mutai, M. U. S. Patent 460 4463,1986.
10. Miyasaka, T., Sawada, S., Nokata, K., Sugino, E., and Mutai, M. Japan Patent; Kokai, 60–17970, 1985.