High-Dose Corticosteroids in Patients with the Adult Respiratory Distress Syndrome

New England Journal of Medicine

Volumn 317, Issue 25, 1987, Pages 1565-1570

  Bernard, Gordon R ^{a,b,c,d,e,f,g}   Luce, John M ^{a,b,c,d,e,f,g}   Sprung, Charles L ^{a,b,c,d,e,f,g}   Rinaldo, Jean E ^{a,b,c,d,e,f,g}   Tate, Robert M ^{a,b,c,d,e,f,g}   Sibbald, William J ^{a,b,c,d,e,f,g}   Kariman, Khalil ^{a,b,c,d,e,f,g}   Higgins, Stanley ^{a,b,c,d,e,f,g}   Bradley, Roberta ^{a,b,c,d,e,f,g}   Metz, Craig A ^{a,b,c,d,e,f,g}   Harris, Thomas R ^{a,b,c,d,e,f,g}   Brigham, Kenneth L ^{a,b,c,d,e,f,g}  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLPREDNISOLONE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ASPIRATION PNEUMONIA; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FATALITY; HUMAN; HUMAN EXPERIMENT; MAJOR CLINICAL STUDY; PANCREATITIS; SEPSIS; SHOCK;

EID: 0023549919     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198712173172504     Document Type: Article

References (41)

1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967; 2: 319–23.
2. Rinaldo JE, Rogers RM. Adult respiratory-distress syndrome: changing concepts of lung injury and repair. N Engl J Med 1982; 306: 900–9.
3. Pepe PE, Hudson LD, Carrico CJ. Early application of positive end-expiratory pressure in patients at risk of the adult respiratory-distress syndrome. N Engl J Med 1984; 311: 281–6.
4. Fein AM, Lippmann M, Holtzman H, Eliraz A, Goldberg SK. The risk factors, incidence, and prognosis of ARDS following septicemia. Chest 1983; 83: 40–2.
5. Bartlett RH, Morris AH, Fairley HB, Hirsch R, O'Connor N, Pontoppidan H. A prospective study of acute hypoxic respiratory failure. Chest 1986; 89: 684–9.
6. Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS. Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome: pathophysiological relevance and possible prognostic value. Lancet 1980; 1: 947–9.
7. Schneider RC, Zapol WM, Carvalho achéal. Platelet consumption and sequestration in severe acute respiratory failure. Am Rev Respir Dis 1980; 122: 445–51.
8. Haynes JB, Hyers TM, Giclas PC, Franks JJ, Petty TL. Elevated fibrin(ogen) degradation products in the adult respiratory distress syndrome. Am Rev Respir Dis 1980; 122: 841–7.
9. Lee CT, Fein AM, Lippmann M, Holtzman H, Kimbel P, Weinbaum G. Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome. N Engl J Med 1981; 304: 192–6.
10. Brigham KL, Meyrick B. Endotoxin and lung injury. Am Rev Respir Dis 1986; 133: 913–27.
11. Staub NC. Pulmonary edema due to increased microvascular permeability. Annu Rev Med 1981; 32: 291–312.
12. Heflin achéal Jr, Brigham KL. Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J Clin Invest 1981; 68: 1253–60.
13. Demling RH, Proctor R, Duy N, Searling JR. Lung lysosomal enzyme release during hemorrhagic shock and endotoxemia. J Surg Res 1980; 28: 269–79.
14. Perel A, Flick M, Staub NC. Methylprednisolone partially protects against microemboli-induced permeability injury in lungs of awake sheep. Am Rev Respir Dis 1980; 121: Suppl: 442. abstract.
15. Jacob HS, Craddock PR, Hammerschmidt DE, Moldow CF. Complementinduced granulocyte aggregation: an unsuspected mechanism of disease. N Engl J Med 1980; 302: 789–94.
16. Shasby DM, Vanbenthuysen KM, Tate RM, Shasby SS, McMurtry I, Repine JE. Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Respir Dis 1982; 125: 443–7.
17. Craddock PR, Hammerschmidt DE, White JG, Dalmasso AP, Jacob HS. Complement (C5a)-induced granulocyte aggregation in vitro: a possible mechanism of complement-mediated leukostasis and leukopenia. J Clin Invest 1977; 60: 260–4.
18. Wilson JW. Treatment or prevention of pulmonary cellular damage with pharmacologic doses of corticosteroid. Surg Gynecol Obstet 1972; 134: 675–81.
19. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 1976; 84: 304–15.
20. Brigham KL, Bowers RE, McKeen CR. Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep. J Clin Invest 1981; 67: 1103–10.
21. Toung TJK, Bordos D, Benson DW, et al. Aspiration pneumonia: experimental evaluation of albumin and steroid therapy. Ann Surg 1976; 183: 179–84.
22. Göteborg BR, Linköping DL. High-dose corticosteroids in the critically ill patient — an update. Acta Chir Scand [Suppl] 1985; 526: 1–140.
23. Lozman J, Dutton RE, English M, Powers SR Jr. Cardiopulmonary adjustments following single high dosage administration of methylprednisolone in traumatized man. Ann Surg 1975; 181: 317–24.
24. Wolfe JE, Bone RC, Ruth WE. Effect of corticosteroids in the treatment of patients with gastric aspiration. Am J Med 1977; 63: 719–22.
25. Sladen A. Methylprednisolone: pharmacologic doses in shock lung syndrome. J Thorac Cardiovasc Surg 1976; 71: 800–6.
26. Sibbald WJ, Anderson RR, Reid B, Holliday RL, Driedger AA. Alveolo-capillary permeability in human septic ARDS: effect of high-dose corticosteroid therapy. Chest 1981; 79: 133–42.
27. Weigelt JA, Norcross JF, Borman KR, Snyder WH III. Early steroid therapy for respiratory failure. Arch Surg 1985; 120: 536–40.
28. Toledo-Pereyra LH, Lin C, Kundler H, Replogle RL. Steroids in heart surgery: a clinical double-blind and randomized study. Am Surg 1980; 46: 155–60.
29. Ashbaugh DG, Maier RV. Idiopathic pulmonary fibrosis in adult respiratory distress syndrome: diagnosis and treatment. Arch Surg 1985; 120: 530–5.
30. Coffin LH, Shinozaki T, DéMeules JE, Browdle DA, Deane RSD, Morgan JG. Ineffectiveness of methylprednisolone in the treatment of pulmonary dysfunction after cardiopulmonary bypass. Am J Surg 1975; 130: 555–9.
31. Schonfeld SA, Ploysongsang Y, DiLisio R, et al. Fat embolism prophylaxis with corticosteroids: a prospective study in high-risk patients. Ann Intern Med 1983; 99: 438–43.
32. Lucas CE, Ledgerwood AM. Pulmonary response of massive steroids in seriously injured patients. Ann Surg 1981; 194: 256–61.
33. Lucas. The cardiopulmonary response to massive doses of steroids in patients with septic shock. Arch Surg 1984; 119: 537–41.
34. Sprung CL, Caralis PV, Marcial EH, et al. The effects of high-dose corticosteroids in patients with septic shock: a prospective, controlled study. N Engl J Med 1984; 311: 1137–43.
35. Flick MR, Murray JF. High-dose corticosteroid therapy in the adult respiratory distress syndrome. JAMA 1984; 251: 1054–6.
36. Pepe PE, Potkin RT, Reus DH, Hudson LD, Carrico CJ. Clinical predictors of the adult respiratory distress syndrome. Am J Surg 1982; 144: 124–30.
37. Friedman LM, Furberg CD, DeMets DL. Fundamentals of clinical trials. Boston: John Wright, 1981:174–94.
38. Detsky AS, Sackett DL. When was a 'negative' clinical trial big enough? How many patients you needed depends on what you found. Arch Intern Med 1985; 145: 709–12.
39. Freiman JA, Chalmers TC, Smith H Jr, Kuebler RR. The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial: survey of 71 “negative” trials. N Engl J Med 1978; 299: 690–4.
40. Zapol WM, Snider MT, Hill JD, et al. Extracorporeal membrane oxygenation in severe acute respiratory failure: a randomized prospective study. JAMA 1979; 242: 2193–6.
41. Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132: 485–9.