Synthesis, Chemical Reactivity, and Antileukemic Activity of 5-Substituted 6,7-Bis(hydroxymethyl)pyrrolo[l,2-c]thiazole Biscarbamates and the Corresponding Sulfoxides and Sulfones

Journal of Medicinal Chemistry

Volumn 30, Issue 11, 1987, Pages 2109-2115

  Anderson, Wayne K ^a   Mach, Robert H ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRODRUG; PYRROLE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; CANCER CHEMOTHERAPY; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; LEUKEMIA P 388; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTINEOPLASTIC AGENTS; CARBAMATES; LEUKEMIA P388; LEUKEMIA, EXPERIMENTAL; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; SULFOXIDES; SUPPORT, U.S. GOV'T, P.H.S.; THIAZOLES;

EID: 0023546420     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00394a030     Document Type: Article

References (6)

1. Vinylogous Carbinolamine Tumor Inhibitors, 21. For,part 20 see: Anderson, W. K.; Heider, A. R. J. Med. Chem. 1986, 29, 2392.
2. Anderson, W. K.; Corey, P. F. J. Med. Chem. 1977, 20, 812.
3. Hansch, C.; Leo, A. J. Substituent Constants for Correlation Analysis in Chemistry and Biology; Wiley: New York, 1979.
4. Anderson, W. K.; Mach, R. H. Synth. Commun. 1986, 16, 911.
5. Bardos, T. J.; Datta-Gupta, N.; Hebborn, P.; Triggle, D. J. Med. Chem. 1965, 8, 167.
6. Pizzorno, M. T.; Albonico,S. M. J. Org. Chem. 1974, 39, 731.