Estrogen formation in the mammalian brain: Possible role of aromatase in sexual differentiation of the hippocampus and neocortex

Steroids

Volumn 50, Issue 4-6, 1987, Pages 459-474

  MacLusky, Neil J ^a   Clark, Ann S ^a   Naftolin, Frederick ^a   Goldman Rakic, Patricia S ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Section of Neuroanatomy Yale University School of Medicine ^*

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; AROMATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN CORTEX; ESTROGEN SYNTHESIS; FEMALE; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MONKEY; NONHUMAN; RHESUS MONKEY; SEX DIFFERENTIATION;

ANIMAL; AROMATASE; BRAIN; CEREBRAL CORTEX; ESTROGENS; HIPPOCAMPUS; HUMAN; SEX DIFFERENTIATION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023520433     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0039-128X(87)90032-8     Document Type: Article

References (73)

1. Aromatization of androstenedione by the diencephalon
2. The formation of estrogens by central neuroendocrine tissue
3. Conversion of androgen to estrogens and other steroids in the vertebrate brain
4. Phylogenetic distribution of aromatase and other androgen- converting enzymes in the central nervous system
5. Sexual differentiation of the central nervous system
6. Gonadal steroidal influences on brain development and sexual differentiation
7. Conversion of androgens to estrogens (aromatization) in discrete regions of the rat brain: Sexual differences and effects of castration
8. Regulation of androgen metabolism and luteinizing hormone-releasing hormone content in discrete hypothalamic and limbic areas of male rhesus macaques
9. Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system
10. Independent masculinization of neuroendocine systems by intracerebral implants of testosterone or estradiol in the neonatal female rat
11. Neural localization for androgen activation of copulatory behavior in the male rat
12. Evidence for the existence of a sexually dimorphic nucleus in the preoptic area of the rat
13. Parameters of neuroendocrine aromatization and estrogen receptor occupation in the male rat
14. Effect of gonadal hormones on enzyme activities in brain and pituitary of male and female rats
15. Structural changes in the preoptic anterior hypothalamic area of the male rat, following neonatal castration and androgen substitution
16. Sexual dimorphism in synaptic organization in the amygdala and its dependence on neonatal hormone environment
17. Changes in Aromatase Activity in the Rat Brain during Embryonic, Neonatal, and Infantile Development
18. Estrogen formation in the developing rat brain: sex differences in aromatase activity during early postnatal life
19. Androgen aromatization and 5α-reduction in ferret brain during perinatal development: effects of sex and testosterone manipulation
20. Aromatase activity in the developing rabbit brain
21. Aromatase activity in the perinatal rat forebrain: effects of age, sex and intrauterine position
22. Sex differences in intellectual functioning
23. Sex differences in human brain asymmetry: a critical survey
24. Effects of prenatal sex hormones on gender-related behavior
25. Left-handedness: association with immune disease, migraine, and developmental learning disorder
26. Sex differences in brain organization for verbal and non-verbal functions
27. Gonadal hormones and sex differences in non-reproductive behaviors in rodents: Organizational and activational influences
28. The effects of testosterone propionate administered before birth on the development of behavior in genetic female rhesus monkeys
29. Neonatal androgens influence the social play of prepubescent rats
30. Sex-dependent behavioral effects of cerebral cortical lesions in the developing rhesus monkey
31. The influence of neonatal androgen on the development of cortical function in rhesus monkey
32. Sex dependent behavioral response to frontal cortical suction lesions in the rat
33. Organizational effects of early gonadal secretions on sexual differentiation in spatial memory
34. Persistent spatial maze learning deficits in hippocampal - lesioned rats across a 7-week postoperative period
35. The effects of puberty and castration on hippocampal dendritic spines of mice. A Golgi study
36. Sexual dimorphism in extent of axonal sprouting in rat hippocampus
37. Neonatal steroid treatment alters axonal sprouting in adult hippocampus: sexually dimorphic development of cholinergic target neurons
38. Morphologic cerebral cortical asymmetry in male and female rats
39. Effects of prenatal stress on sexually dimorphic asymmetries in the cerebral cortex of the male rat
40. The effects of neonatal gonadectomy and prenatal stress on cortical thickness and asymmetry in rats
41. Prenatal stress feminizes and demasculinizes the behavior of males
42. Maternal stress alters plasma testosterone in fetal males
43. Cerebral hemispheric asymmetry in humans
44. Sex differences in the fetal human corpus callosum
45. Sexual dimorphism in the human corpus callosum: an extension and replication study
46. The development of estrogen receptor systems in the rat brain: Perinatal development
47. The development of estrogen receptor systems in the rat brain: Postnatal development
48. Androgen and estrogen receptors in the developing mouse brain
49. Androgen and estrogen receptors in perinatal ferret brain
50. Estrogen binding in the neonatal neocortex
51. Perinatal development of estrogen receptors in mouse brain assessed by radioautography, nuclear isolation and receptor assay
52. Estrogen formation and binding in the cerebral cortex and diencephalon of the newborn rhesus monkey
53. Brain myelination after neonatal administration of estradiol
54. Gonad-brain relationships: Precocious brain maturation after estradiol in rats
55. Regional changes in amino acid concentration in the developing brain and the effects of neonatal administration of estradiol
56. On the genesis of sexual differentiation of the central nervous system: morphogenetic consequences of steroidal exposure and possible role of alpha-fetoprotein
57. Prenatal gonadal hormones and sex differences in human behavior
58. Gonadal steroid-brain interactions in sexual differentiation
59. Brain cell nuclear retention of testosterone metabolites, 5α-dihydrotestosterone and estradiol-17β in adult rats
60. Autoradiographic localization of estradiol-binding neurons in the rat hippocampal formation and entorhinal cortex
61. Conversion of androstenedione to estrone by neural tissues from fetal and noenatal rats
62. Estrogen formation in the brain
63. Steroid hormone binding and metabolism in cerebral cortex and limbic structures of the developing rhesus monkey
64. Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey
65. Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro Implication for sexual differentiation
66. Enzymatic aromatization of steroids I: Effects of oxygen and carbon monoxide on the intermediate steps of estrogen biosynthesis
67. Aromatase activity in explant cultures of the developing mouse brain: is the rodent cerebral cortex a target for locally synthesized estrogen?
68. Regulation of brain aromatase activity in rats
69. Effects of gonadectomy and androgen treatment on aromatase activity in the fetal monkey brain
70. Atlas of estrogen target cells in rat brain
71. 3H-estradiol
72. Androgen receptors in the cerebral cortex of fetal female rhesus monkeys