The BCR/ABL hybrid gene

Bailliere's Clinical Haematology

Volumn 1, Issue 4, 1987, Pages 983-999

  Groffen, John ^a   Heisterkamp, Nora ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BOOK; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; HUMAN; HUMAN CELL; HYBRID GENE; ONCOGENE; ONCOGENE BCR ABL;

ANIMAL; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 9; DNA, NEOPLASM; HUMAN; LEUKEMIA, LYMPHOCYTIC, ACUTE; MICE; PHILADELPHIA CHROMOSOME; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ABL; RESTRICTION MAPPING; RNA, MESSENGER; TRANSLATION, GENETIC; TRANSLOCATION (GENETICS);

EID: 0023488211     PISSN: 09503536     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-3536(87)80035-5     Document Type: Article

References (77)

1. Lymphosarcoma: virus induced thymic-independent disease in mice
2. Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromsome in chromic myelocytic leukemia
3. Localization of the human c-sis oncogene in Ph'-positive and Ph'-negative chronic myelocytic leukemia by in situ hybridization
4. c-abl and bcr are rearranged in a Ph'-negative CML patient
5. Alternative splicing of a Drosophila tropomyosin gene generates muscle tropomyosin isoforms with different carboxy-terminal ends
6. Blast crisis of chronic myeloid leukaemia (CML). I. Presentation simulating acute lymphoid leukaemia (ALL)
7. Alternative 5′ exons in c-abl mRNA
8. The chronic myelogenous leukemia specific p210 protein is the product of the bcr/abl hybrid gene
9. The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages
10. Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene
11. Altered transcription of an oncogene in chronic myeloid leukaemia
12. Chronic myelogenous leukemia: recent advances
13. A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia
14. The Ph' chromosome in childhood leukaemia
15. 1-positive ALL
16. Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K562
17. Altered transcription of the c-abl oncogene in K-562 and other chronic myelogenous leukemia cells
18. A human oncogene homologous to the transforming gene (v-sis) of simian sarcoma virus
19. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
20. bcr rearrangement and translocations of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia
21. Molecular analysis of both translocation products of a Philadelphia positive CML patient
22. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
23. Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter
24. Two mRNAs can be produced from a single immunoglobulin gene by alternative RNA processing pathways
25. Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor
26. +) acute lymphocytic leukemia
27. A novel 8 kb ablRNA transcript in chronic myelogenous leukemia
28. The molecular biology of chronic myelogenous leukaemia
29. Worshop letter: rapid progress in chronic myelogenous leukemia
30. Rearrangement of the bcr gene in Philadelphia chromosome-negative chronic myeloid leukemia
31. Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA
32. Isolation of human oncogene sequences (v-fes homolog) from a cosmid library
33. Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products
34. c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia
35. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
36. The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr-abl transcript
37. cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia
38. The human v-abl cellular homologue
39. Chromosomal localization of human cellular homologues of two viral oncogenes
40. Structural organization of the bcr gene and its role in the Ph' translocation
41. Localization of the c-abl oncogene adjacent to a translocation breakpoint in chronic myelocytic leukaemia
42. Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
43. Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell free system
44. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
45. Evidence against a scanning model of RNA splicing
46. A novel c-abl protein product in Philadelphiapositive acute lymphoblastic leukaemia
47. Recurring chromosomal abnormalities and lymphoma
48. Variable breakpoints on the Philadelphia chromosome in chronic myelogenous leukemia
49. Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome
50. Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes
51. Expression of the mouse HPRT gene: deletional analysis of the promoter region of an X-chromosome linked housekeeping gene
52. Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
53. Genomic diversity correlates with clinical variation in Ph'-negative chronic myeloid leukaemia
54. Chromosomes and causation of human cancer and leukemia. XXV. Significance of the Ph' (including unusual translocations) in various acute leukemias
55. Correction: Nucleotide Sequence of Abelson Murine Leukemia Virus Genome: Structural Similarity of its Transforming Gene Product to other Onc Gene Products with Tyrosinespecific Kinase Activity
56. Cells non-productively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and non-structural components
57. In vitro transformation of lymphoid cells by Abelson murine leukemia virus
58. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
59. Drosophila has one myosin heavy-chain with three developmentally regulated transcripts
60. Direct transformation of 3T3 cells by Abelson murine leukemia virus
61. Structure of the Abelson murine leukemia virus genome
62. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
63. Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl gene
64. Trans splicing of mRNA precursors
65. Evidence of new chimeric bcr-c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome
66. Evidence that the Phl gene encodes a 160,000 dalton phosphoprotein with associated kinase activity
67. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
68. Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes
69. Expression of an Abelson murine leukemia virus encoded protein in Escherichia coli caused extensive phosphorylation of tyrosine residues
70. The mouse c-abl locus: molecular cloning and characterization
71. Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia
72. Expression of cellular homologue of retroviral oncogenes in human hematopoietic cells
73. Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine
74. A transformation defective mutant of Abelson murine leukemia virus lacks protein kinase activity
75. A single mouse α-amylase gene specifies two different tissue-specific mRNAs
76. The chromosomal basis of human neoplasia
77. Splicing in adenovirus and other animal viruses