Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm

Bioinformatics

Volumn 3, Issue 4, 1987, Pages 345-349

  Verotta, Davide ^a   Sheiner, Lewis B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY - MATHEMATICAL MODELS; BIOMEDICAL ENGINEERING - DRUG THERAPY; COMPUTER PROGRAMS; MATHEMATICAL TECHNIQUES - ALGORITHMS;

NON-PARAMETRIC MODELS; PARAMETRIC MODELS; PHARMACODYNAMICS; PHARMACOKINETICS;

DRUG PRODUCTS;

ADRENERGIC BETA ANTAGONISTS; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; PROPANOLAMINE DERIVATIVE; TERTATOLOL;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; COMPUTER PROGRAM; DRUG EFFECT; EXERCISE TEST; HEMODYNAMICS; HUMAN; METHODOLOGY; PHARMACOKINETICS; PHARMACOLOGY; RANDOMIZATION;

ADRENERGIC BETA-ANTAGONISTS; ALGORITHMS; EXERCISE TEST; HEMODYNAMICS; HUMAN; MODELS, BIOLOGICAL; PHARMACOKINETICS; PHARMACOLOGY; PROPANOLAMINES; RANDOM ALLOCATION; SOFTWARE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023450020     PISSN: 13674803     EISSN: None     Source Type: Journal    
DOI: 10.1093/bioinformatics/3.4.345     Document Type: Article

References (5)

1. Chemiault Y, Pros U F, Karpouzas, I and Hotchen, M. (1986) Mathematical modelling accounting for discrepancies between blood levels and pharmaco- dynamic effects of a drug. Application to the numerical optimization of tertatolol. Int. Bio-Med. Comp., 18, 283-300
2. Fuseau, E and Sheiner L B. (1984) Sumiltaneous modelling of pharmacokinetics and pharmacodynamics with a non-parametnc pharmacodynamic model Chn. Pharmacol Ther., 35, 733-741
3. Segre G (1968) Kinetics of interaction between drugs and biological systems II Farmaco, 23, 907-918
4. Sheiner L B, Stansky, D R, Vozeh S., Miller, R D and Ham J (1979) Simultaneous modeling of pharmacokinetics and pharmacodynamics application to d-tubocuranne. Qm Pharmacol Ther., 25, 358-371
5. Unadkat J.D., Bartha F and Sheiner L B (1986) Simultaneous modelling of pharmacokinetics and pharmacodynamics with non-parametnc kinetic and dynamic models Clin Pharmacol Ther, 40, 86-93