Short-Term Metabolic Effects of Recombinant Human Insulin-like Growth Factor I in Healthy Adults

New England Journal of Medicine

Volumn 317, Issue 3, 1987, Pages 137-140

  Guler, Hans Peter ^a   Zapf, Jürgen ^a   Froesch, E Rudolf ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; SOMATOMEDIN; SOMATOMEDIN C;

DRUG EFFICACY; ENDOCRINE SYSTEM; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; BLOOD GLUCOSE; COMPARATIVE STUDY; EPINEPHRINE; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCAGON; GROWTH HORMONE; HUMAN; HYDROCORTISONE; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LACTATES; LIPOLYSIS; MALE; MIDDLE AGE; NOREPINEPHRINE; RECOMBINANT PROTEINS; SOMATOMEDINS; SUPPORT, NON-U.S. GOV'T;

EID: 0023276184     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198707163170303     Document Type: Article

References (25)

1. Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 1978; 253: 2769–76.
2. Rinderknecht Primary structure of human insulin-like growth factor II. FEBS Lett 1978; 89: 283–6.
3. Froesch ER, Zapf J. Insulin-like growth factors and insulin: comparative aspects. Diabetologia 1985; 28: 485–93.
4. Zapf J, Schmid Ch, Froesch ER. Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin Endocrinol Metab 1984; 13: 3–30.
5. Hintz RL. Plasma forms of somatomedin and the binding protein phenomenon. Clin Endocrinol Metab 1984; 13: 31–42.
6. Baxter RC. The somatomedins: insulin-like growth factors. Adv Clin Chem 1986; 25: 49–115.
7. Schwander JC, Hauri C, Zapf J, Froesch ER. Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology 1983; 113: 297–305.
8. Mathews LS, Norstedt G, Palmiter RD. Regulation of insulin-like growth factor I gene expression by growth hormone. Proc Natl Acad Sci USA 1986; 83: 9343–7.
9. Horiai H, Asada T, Seki J, et al. Growth-promoting effect of recombinant human insulin-like growth factor I/somatomedin C in hypophysectomized rats. Presented at the International Symposium on GRF, Growth Hormone and Somatomedin, Tokyo. 1986.
10. Guler HP, Zenobi P, Zapf J, et al. IGF I and II and recombinant human IGF I are hypoglycemic in the rat, mini-pig, and men. Endocrinology 1986; 118: Suppl: 129. abstract.
11. Schoenle E, Zapf J, Humbel RE, Froesch ER. Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature 1982; 296: 252–3.
12. Schoenle E, Zapf J, Hauri C, Steiner T, Froesch ER. Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats. Acta Endocrinol (Copenh) 1985; 108: 167–74.
13. Zapf J, Hauri C, Waldvogel M, Froesch ER. Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats. J Clin Invest 1986; 77: 1768–75.
14. Zapf J, Walter H, Froesch ER. Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 1981; 68: 1321–30.
15. Da Prada M, Zürcher G. Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline, and dopamine within the femtomole range. Life Sci 1976; 19: 1161–74.
16. Holst JJ, Aasted B. Production and evaluation of glucagon antibodies for radioimmunoassay. Acta Endocrinol (Copenh) 1974; 77: 715–26.
17. Falholt K, Lund B, Falholt W. An easy colorimetric micromethod for routine determination of free fatty acids in plasma. Clin Chim Acta 1973; 46: 105–11.
18. Poggi C, Le Marchand-Brustel Y, Zapf J, Froesch ER, Freychet P. Effects and binding of insulin-like growth factor I in the isolated soleus muscle of lean and obese mice: comparison with insulin. Endocrinology 1979; 105: 723–30.
19. Oelz O, Jakob A, Froesch ER. Nonsuppressible insulin-like activity (NSILA) of human serum. V. Hypoglycaemia and preferential metabolic stimulation of muscle by NSILA-S. Eur J Clin Invest 1970; 1: 48–53.
20. Gerich J, Davis J, Lorenzi M, et al. Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol 1979; 236: E380–E385.
21. Tannenbaum GS, Guyda HJ, Posner BI. Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain. Science 1983; 220: 77–9.
22. Abe H, Molitch ME, Van Wyk JJ, Underwood LE. Human growth hormone and somatomedin C suppress the spontaneous release of growth hormone in unanesthetized rats. Endocrinology 1983; 113: 1319–24.
23. Ceda GP, Davis RG, Hoffman AR. Somatomedin regulation of growth hormone secretion from perfused rat anterior pituitary cells. Endocrinology 1986; 118: Suppl: 126. abstract.
24. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 1981; 212: 1279–81.
25. Yamashita S, Melmed S. Insulin-like growth factor I action on rat anterior pituitary cells: suppression of growth hormone secretion and messenger ribonucleic acid levels. Endocrinology 1986; 118: 176–82.