Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomas

The Journal of Pathology

Volumn 151, Issue 4, 1987, Pages 285-291

  Quirke, Philip ^a   Dixon, Michael F ^a   Clayden, Andrew D ^a   Durdey, Paul ^a   Dyson, John E D ^a   Williams, Norman S ^a   Bird, Colin C ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

cell proliferation; DNA aneuploidy; Flow cytometry; rectal adenocarcinoma; tumour heterogeneity

Indexed keywords

ANEUPLOIDY; CELL GROWTH; DIAGNOSIS; DNA CONTENT; FLOW CYTOMETRY; HETEROGENEITY; HISTOLOGY; HUMAN; HUMAN CELL; LARGE INTESTINE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; RECTUM CARCINOMA;

ADENOCARCINOMA; ANEUPLOIDY; DNA, NEOPLASM; FLOW CYTOMETRY; HUMANS; MITOSIS; PROGNOSIS; RECTAL NEOPLASMS; TIME FACTORS;

EID: 0023276103     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1711510408     Document Type: Article

References (31)

1. DNA distribution in human colon carcinomas and its relationship to clinical behaviour
2. The influence of tumour cell DNA abnormalities on survival in colorectal cancer
3. Tumour DNA content in the prognosis of colorectal carcinoma
4. Preoperative staging of rectal neoplasm and the impact on clinical management
5. A mosaic subpopulation structure of human colorectal carcinomas demonstrated by flow cytometry
6. Large bowel carcinomas with different ploidy, related to secretory component, IgA, and CEA in epithelium and plasma
7. Ploidy and proliferation patterns in colorectal adenocarcinomas related to Dukes' classification and to histopathological differentiation: a flow cytometric DNA study
8. Heterogeneity of colorectal adenocarcinomas evaluated by flow cytometry and histopathology
9. The grading and prognosis of carcinoma of the colon and rectum
10. A method for analysis of cellular DNA content of paraffin‐embedded pathological material using flow cytometry
11. Convention on nomenclature for DNA cytometry
12. Application of DNA flow cytometry to paraffin‐embedded archival material for the study of aneuploidy and its clinical significance
13. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II Analysis and examples
14. Predictive assays for the therapy of rectum carcinoma
15. Is DNA aneuploidy a good prognostic indicator in patients with colorectal cancer?
16. Local recurrence of rectal adenocarcinoma is caused by inadequate surgical resection. A histopathological study of lateral tumour spread and surgical excision
17. The classification of cancer of the rectum
18. The limitations of preoperative grading of rectal carcinoma
19. Observer variation in the histological grading of rectal carcinoma
20. DNA pattern and cytological findings in fine needle aspirates of untreated prostatic tumours. A flow cytofluorometric study
21. The clinical significance of ploidy and proliferation in the clinical and biological evaluation of bladder tumours: A study of 100 untreated cases
22. The clonal evolution of tumor cell populations
23. Flow cytometry of colorectal carcinoma with three year follow up
24. Should flow cytometric DNA analysis precede definitive surgery for colon carcinoma
25. S phase fractions of colorectal carcinomas related to pathologic and clinical features
26. Early effects of preoperative irradiation upon the cell cycle composition in rectal adenocarcinomas. A flow‐cytometric DNA investigation
27. Prevalence and prognosis of individual clinical and pathological variables associated with colorectal carcinoma
28. Prognostic correlations of operable carcinoma of the rectum
29. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases
30. DNA flow cytometry of histological material from human gastric cancer