Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: Interaction between the chemical carcinogen and endogenous murine leukaemia viruses

Carcinogenesis

Volumn 8, Issue 1, 1987, Pages 163-172

  Warren, W ^a   Lawley, P D ^a   Gardner, E ^a   Harris, G ^a,b   Ball, J K ^a,c   Cooper, C S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; METHYLNITROSOUREA;

AKR MOUSE; ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; HEREDITY; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; ONCOGENE C MYC; THYMOMA; THYMUS;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; COCARCINOGENESIS; DNA RESTRICTION ENZYMES; KINETICS; LEUKEMIA VIRUS, MURINE; METHYLNITROSOUREA; MICE; THYMOMA; THYMUS NEOPLASMS; TRANSFECTION;

EID: 0023265616     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/8.1.163     Document Type: Article

References (62)

1. Levy, J.A. (1973) Xenotropic viruses: murine leukemia viruses associated with NIH/Swiss, NZB and other mouse strains. Science, 182, 1151-1153.
2. Rowe, W.P., and Pincus, T. (1972) Quantitative studies of naturally occurring murine leukaemia virus infection of AKR mice. J. Exp. Med., 135, 429-436.
3. Hartley J.W., Wolford, N.K., Old, L.J., and Rowe, W.P., (1977) A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc. Natl. Acad Sci. USA, 74, 789-792.
4. Chattopadhyay, S.K., Cloyd, M.W., Linemeyer, D.L., Lander, M.R., Rands, E. and Lowy, D.R., (1982) Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature, 295, 25-31.
5. Qiattopadhyay, S.K., Lander, M.R., Gupta, S., Rands, E. and Lowy, D.R., (1981) Origin of mink cytopathic focus-forming (MCF) viruses: comparison with ecotropic and xenotropic murine leukemia virus genomes. Virology, 113, 465-483.
6. Chien, Y., Verma, l.M., Shih, T.H., Scolnick, E.M., and Davidson, N. (1978) Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J. Virol., 28, 352-360.
7. Elder, J.H., Gautsch, J.W., Jensen, F.C., Lemer, A., Hartley, J.W. and Rowe, W.P., (1977) Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants. Proc. Natl Acad Sci. USA, 74, 4676-4680.
8. Lung, M.L., Hering, C., Hartley, J.W., Rowe, W.P., and Hopldns, N. (1979) Analysis of the genomes of mink cell focus-forming murine type C viruses: a progress report Cold Spring Harbor Symp. Quant. Biol., 44, 1269-1274.
9. Rommdaere, J., Faller, D.V., and Hopkins, N. (1978) Characterization and mopping of RNase T,-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses. Proc. NatL Acad. Sd. USA, 75, 495-499.
10. Cloyd, M.W., (1983) Characterization of target cells for MCF viruses in AKR mice. Cell, 32, 217-225.
11. Cloyd, M.W., Hartley, J.W. and Rowe, W.P., (1980) Lymphomagenicity of recombinant mink cell focus-inducing murine luekemia viruses. J. Exp. Med., 151, 542-552.
12. O’Donnell, P.V., Stockert, E., Obala, Y. and Old, LJ. (1981) Leukemogenic properties of AKR dualtropic (MCF) viruses: amplification of murine leukemia virus-related antigens on thymocytes and acceleration of leukemia development in AKR mice. Virology, 112, 548-563.
13. Nowinski, R.C., and Hays, E.F., (1978) Oncogenicity of AKR endogenous leukemia viruses. J. Virol., 27, 13-18.
14. Pedersen, F.S., Crowther, R.L., Tenney, D.Y., Reimold, A.M., and Hasel-tine, W.A., (1981) Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour. Nature, 292, 167-170.
15. Herr, W. and Gilbert, W. (1983) Somatically acquired recombinant murine leukemia proviruses in thymic leukemias of AKR/J mice. J. VuoL, 46, 70-82.
16. Corcoran, L.M., Adams, J.M., Dunn, A.R., and Cory, S. (1984) Murine T. lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell, 37, 113-122.
17. Cuypers, H.T., Selten, G., Quint, W., Zijlstra, M., Robanus-Maandag, E., Boelens, W., van Wezenbeek, P., Melief, C. and Bems, A. (1984) Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell, 37, 141-150.
18. Li, Y., Holand, C.A., Hartley, J.W. and Hopkins, N. (1984) Viral mtegration near c-myc in 10-20% of MCF 247-induced AKR lymphomas. Proc. NatL Acad. Sci. USA, 81, 6808-6811.
19. Selten, G., Cuypers, H.T., and Bems, A. (1985) Proviral activation of the putative oncogene Pint-1 in MuLV induced T-cell lymphomas. EMBO, J., 4, 1793-1798.
20. Selten, G., Cuypers, H.T., Zijlstra, M., Melif, C. and Bems, A. (1984) Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO, J., 3, 3215-3222.
21. Steffen, D. (1984) Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas. Proc. Natl. Acad. Sci. USA, 81, 2097-2101.
22. Lane, M.A., Sainten, A. and Cooper, G.M., (1982) Stage-specific transforming genes of human and mouse B-and T-lymphocyte neoplasms. Cell, 28, 873-880.
23. Frei, J.V. and Lawley, P.D., (1980) Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response. J. Natl. Cancer Inst., 64, 845-856.
24. Frei, J.V., (1980) Methylnitrosourea induction of thymomas in AKR mice requires one or two ‘hits’ only. Carcinogenesis, 1, 721-723.
25. Mayer, A. and Dorsh-HSsler, K. (1982) Endogenous MuLV infection does not contribute to onset of radiation or carcinogen-induced murine thymoma. Nature, 295, 253-255.
26. Chinsky, J., Lilly, F. and Childs, G. (1985) Comparison of chemically induced and spontaneous murine thymic lymphomas in RF and AKR mice: differential expression of c-myc and c-myb. Proc. Natl. Acad. Sci. USA, 82, 565-569.
27. Guerrero, I., Calzada, P., Meyer, A. and Pellicer, A. (1984) A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc. Natl. Acad. Sd. USA, 81, 202-205.
28. Richie, E.R., Naim, R.S., and Becker, F.F., (1985) Proviral structure and differentiation antigen phenotype of spontaneous and chemically induced AKR lymphomas. Cancer Res., 45, 2802-2806.
29. Graham, F.L., and van Der Eb, AJ. (1973) A new technique for the assay of infectivity of tumour adenoviruses 5 DNA. Virology, 52, 456-467.
30. Lowy, D.R., Rands, E. and Scolnick, E.M., (1978) Helper-independent transformation by unintegrated Harvey sarcoma virus DNA. J. Virol., 26, 291-298.
31. Stowe, N.D., and Wilkie, N.M., (1976) An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. J. Gen. ViroL, 33, 447-458.
32. Steffen, D. and Weinberg, R.A., (1978) The integrated genome of murine leukemia virus. Cell, 15, 1003-1010.
33. Southern, E.M., (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98, 503-517.
34. Rigby, P.W.J., Dieckmarm, M., Rhodes, C. and Berg, P. (1977) Labelling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Biol., 113, 237-251.
35. Feinberg, A.P., and Vogelstein, B. (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. AnaL Biochem, 132, 6-13.
36. DeFeo, D., Gonda, M.A., Young, H.A., Chang, E.H., Lowy, D.R., Scdnick, E.M., and Ellis, R.W., (1981) Analysis of two divergent rat genomic clones homologous to the transforming genes of Harvey murine sarcoma virus. Proc. Natl. Acad. Sd. USA, 78, 3328-3332.
37. Shen-Ong, G.L.C, Kealh, E.J., Piccoli, S.P., and Cote, M.D., (1982) Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas. Cell, 31, 443-452.
38. Marth, J.D., Peet, R., Krebs, E.G., and Perhnutter, R.M., (1985) A lymphocyte-specific protein-tyrosine kinase is rearranged and overexpresed in murine T cell lymphoma LSTRA. Cell, 43, 393-404.
39. Jenkins, J.R., Rudge, K., Redmond, S. and Wade-Evans, A. (1984) Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53. Nudeic Adds Res., 12, 5609-5626.
40. Graham, M., Adams, J.M. and Cory, S. (1985) Murine T lymphomas with retroviral inserts in the chromosomal 15 locus for piasmocytoma variant translocation. Nature, 314, 740-743.
41. Nordling, C.O., (1985) New theory on cancer-inducing mechanism. Br. J. Cancer, 7, 68-72.
42. Moolgavkar, S.H., and Knudson, A.G. Jr., (1981) Mutation and cancer a model for human carcinogenesis. J. Natl. Cancer Inst., 66, 1037-1052.
43. Marshall, C., J., (1985) Human oncogenes. In Weiss, R., Teich, N., Varmus, H. and Coffin, J. (eds), RNA Tumour Viruses. Cold Spring Harbor Laboratory Press, New York, Vol. 2, pp. 487-557.
44. Mowat, M., Cheny, A., Kimiua, N., Bernstein, A., Benchimol, S. (1985) Rearrangements of the cellular p53 gene in erythroleukaemic cells tranformed by Friend virus. Nature, 314, 633-636.
45. Eva, A. and Aaronson, S.A., (1983) Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene. Sdence, 220, 955-956.
46. Parada, L.F., and Weinberg, R.A., (1983) Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene. MoL Cell. Biol., 3, 2298-2301.
47. Balmain, A., Ramsden, M., Bowden, G.T., and Smith, I. (1984) Activation of mouse cellular Harvey-rar gene in chemically induced benign skin papillomas. Nature, 307, 658-660.
48. Sukumar, S., Notario, V., Martin-Zanca, D. and Barbacid, M. (1983) Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature, 306, 658-661.
49. Marshall, C.J., Vousden, K.H., and Phillips, D.H., (1984) Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo[a]pyrene diol-epoxide. Nature, 310, 586-589.
50. Frei, J.V., Swenson, D.H., Warren, W. and Lawley, P.D., (1978) Alkylation of DNA in vivo in various organs of C57BL mice by the carcinogens AJ-methyl-/V-nitrosourea, V-ethyl-V-nitrosourca and ethylmethanesulphooate in relation to induction of thymic lymphoma: some applications of high-pressure liquid chromatography. Biochem., J., 174, 1031-1044.
51. Zarbl, H., Sukumar, S., Arthur, A.V., Martin-Zanca, D. and Barbacid, M. (1985) Direct mutagenesis of Ha-rar-1 oncogenes by V-nitroso-A-methylurca during initiation of mammary carcinogenesis in rats. Nature, 315, 382-385.
52. Guerrero, I., Villasante, A., Corces, V. and Pellicer, A. (1985) Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proc. Natl. Acad. Sd. USA, 82, 7810-7814.
53. Cooper, G.M., and Neiman, P.E., (1980) Transforming genes of neoplasms induced by avian lymphoid leukosis viruses. Nature, 287, 656-659.
54. Lane, M.A., Sainten, A. and Cooper, G.M., (1981) Activation of related transforming genes in mouse and human mammary carcinomas. Proc. NatL Acad. Sd. USA, 78, 5185-5189.
55. Land, H., Parada, L.F., and Weinberg, R.A., (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature, 304, 596-602.
56. Tsichlis, P.N., Strauss, P.G., and Lohse, M.A., (1985) Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis. J. ViroL, 56, 258-267.
57. Peters, G., Lee, A.E., and Dickenson, C. (1986) Concerted activation of two potential proto-oncogenes in carcinomas induced by mouse mammary tumour virus. Nature, 320, 628-631.
58. Zijlstra, M., Cuypers, H.T., Selten, G., Radaszkiewicz, T., Koolwijk, P., DeGoede, R.E.Y., Schoenmakers, H.J., Bems, A. and Melief, C.J.M. (1984) Primary mokmey murine leukaemia virus (MuLV)-induced T-cell lymphomas in the mouse are often oligoclonal in origin. Annual Report Karl Landsteiner Foundation, pp. 115-117.
59. Famulari, N.G., (1983) Murine leukemia viruses with recombinant env genes: a discussion of their role in leukemogenesis. Carr. Top. Microbiol Immunol, 103, 73-108.
60. Pazmino, N.H., McEwan, R., Ihle, J.N. (1978) Radiation leukaemia in C57BL/6. ID. Correlation of altered expression of terminal deoxynucleotidyl transferase to induction of leukaemia. J. Exp. Med., 148, 1338-1350.
61. Haran-Ghera, N. (1980) Potential leukemic cells among bone marrow cells of young AKR/J mice. Proc. NatL Acad. Sci. USA, 77, 2923-2926.
62. Hayes, E.F., (1982) Bone marrow progenitor cells of AKR mice give rise to thymic lymphoma cells. Leukemia Res., 6, 429-432.