Effects of ethane dimethane sulphonate (EDS) on seminiferous tubule function in rats

International Journal of Andrology

Volumn 10, Issue 4, 1987, Pages 625-634

  O'LEARY, P C ^a   JACKSON, A E ^a   IRBY, D C ^a   DE KRETSER, D M ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Ethane dimethane sulphonate; fluid production; Leydig cell; seminiferous tubule; Sertoli cell; spermatogenesis

Indexed keywords

ETHYLENE GLYCOL DIMESYLATE; TESTOSTERONE;

ANIMAL EXPERIMENT; DRUG EFFICACY; DRUG MECHANISM; MALE GENITAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; SEMINIFEROUS TUBULE; SPERMATOGENESIS;

ANDROGEN-BINDING PROTEIN; ANIMAL; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE; MALE; MESYLATES; ORGAN WEIGHT; PROSTATE; RATS; RATS, INBRED STRAINS; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTIS; TESTOSTERONE;

EID: 0023260483     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.1987.tb00362.x     Document Type: Article

References (29)

1. The male rabbit. Determination of daily sperm production by means of testicular homogenates
2. In vitro bioassay of inhibin in testes of normal and cryptorchid rats
3. Effects of hypophysectomy and subsequent FSH and testosterone treatment on inhibin production by adult rat testes
4. Effects of testosterone on testicular inhibin and fluid production in intact and hypophysectomized adult rats
5. The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium
6. Suppression of testicular androgen synthesis in the rat by ethane‐1,2‐dimethanesulphonate
7. Comparative effects of methylene, ethylene and propylene dimethanesulphonates on the rat reproductive system
8. Androgen binding protein as a marker for Sertoli cell function
9. The effects of ethylene dimethane sulphonate (EDS) on rat Leydig cells: evidence to support a connective tissue origin of Leydig cells
10. Comparative protective actions of gonadotrophins and testosterone against the antispermatogenic action of ethane dimethane sulphonate
11. Gonadotrophin levels in male rats following impairment of Leydig cell function by ethylene dimethane sulphonate
12. Hormone antagonism to the antispermatogenic effect of ethylene dimethane sulphonate in rats
13. Seminiferous tubule fluid production and interstitial fluid production. 1. Effects of age and hormone regulation in immature rats
14. Studies on seminiferous tubule fluid production in the adult rat: effect of hypophysectomy and treatment with FSH, LH and testosterone
15. Selective destruction and regeneration of rat Leydig cells in vivo
16. Morphological and functional characterization of interstitial cells from mouse testes fractionated on Percoll density gradients
17. Specific destruction of Leydig cells in mature rats after in vivo administration of ethane dimethane sulphonate (EDS)
18. Leydig cell resistance to the cytotoxic effect of ethylene dimethane sulphonate in the adult rat testis
19. Gonadotrophin response after castration and selective destruction of the testicular interstitium in the normal and azoospermatogenic rat
20. Temporal changes in serum androgen after temporary impairment of Leydig cell function by ethane‐2,1‐dimethane sulphonate
21. Ethylene dimethane sulfonate destroys Leydig cells in the rat testis
22. Regulation of the seminiferous epithelium
23. Spermatogenesis and the Sertoli cell
24. Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats
25. The intratesticular distribution of testosterone and the relationship to levels of a peptide that stimulates testosterone production
26. Intratesticular secretion of a factor(s) with major stimulatory effects on Leydig cell testosterone secretion in vitro
27. Intratesticular factors and testosterone secretion: the effect of treatment with ethane dimethane sulphonate (EDS) and the induction of seminiferous tubule damage
28. The effects of ligation of the vasa efferentia and vasectomy on testicular function in the adult rat
29. Hormonal control of mammalian spermatogenesis