Effect of poly(ADP-ribose) synthetase inhibitor administration to streptozotocin-induced diabetic rats on insulin and glucagon contents in their pancreas

Diabetes Research and Clinical Practice

Volumn 3, Issue 3, 1987, Pages 135-142

  Shima, Kenji ^a   Hirota, Meisei ^a   Sato, Mitsuyo ^a   Numoto, Satoshi ^b   Oshima, Ichiyo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b Kochi City Office   (Japan)

Author keywords

3 Aminobenzamide; Glucagon immunoreactivity; Glucagon containing cell; Glucagon like immunoreactivity; Insulin containing cell; Insulin content; Nicotinamide; Streptozotocin

Indexed keywords

3 AMINOBENZAMIDE; GLUCAGON; INSULIN; NICOTINAMIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; CHEMICAL INJURY; DIABETES MELLITUS; DRUG DOSE; DRUG EFFICACY; ENDOCRINE SYSTEM; HISTOLOGY; INJURY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PANCREAS; PANCREAS ISLET CELL; PHARMACOLOGY; PRELIMINARY COMMUNICATION; PRIORITY JOURNAL; RAT;

ANIMALS; BENZAMIDES; DIABETES MELLITUS, EXPERIMENTAL; GLUCAGON; INSULIN; MALE; NIACINAMIDE; PANCREAS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, INBRED STRAINS;

EID: 0023260303     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(87)80019-0     Document Type: Article

References (19)

1. Streptozotocin diabetes: time course of irreversible B-cell damage: further observations on prevention by nicotinamide
2. Protection against diabetes with nicotinamide
3. Influence of nicotinamide and pyridine nucleotide on streptozotocin and alloxan-induced pancreatic B-cell cytotoxicity
4. Complete protection from low-dose streptozotocin-induced diabetes in mice
5. Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis
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9. DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin
10. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis
11. Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide
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