Plasmodium falciparum: Immunogenicity of circumsporozoite protein constructs produced in Escherichia coli

Experimental Parasitology

Volumn 63, Issue 2, 1987, Pages 166-172

  Wirtz, Robert A ^a   Ballou, W Ripley ^a   Schneider, Imogene ^a   Chedid, Louis ^b   Gross, Mitchell J ^c   Young, James F ^c   Hollingdale, Michael ^d   Diggs, Carter L ^a   Hockmeyer, Wayne T ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b INSTITUT PASTEUR   (France)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Biomedical Research Institute   (United States)

Author keywords

Antibody; Bacterium; Escherichia coli; Malaria, human; Plasmodium falciparum; Protein, Circumsporozoite, Immunogenicity; Protozoa, parasitic; Sporozoite

Indexed keywords

MONOCLONAL ANTIBODY; PARASITE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ESCHERICHIA COLI; ETIOLOGY; EXPERIMENTAL INFECTION; GENETIC ENGINEERING; IMMUNOGENICITY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PREVENTION; PRIORITY JOURNAL; PROTOZOON; SPOROZOITE; VIRULENCE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; ESCHERICHIA COLI; IMMUNIZATION; MICE; MICE, INBRED C57BL; MOLECULAR WEIGHT; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS;

ANIMALIA; ESCHERICHIA COLI; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0023256626     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/0014-4894(87)90158-5     Document Type: Article

References (14)

1. Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum
2. Intrinsic and extrinsic factors in protein antigenic structure
3. Molecular size and shape of antigens
4. Infectivity to mosquitoes of Plasmodium falciparum clones grown in vitro from the same isolate
5. Biologic activity of a new synthetic muramyl peptide adjuvant devoid of pyrogenicity
6. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum
7. Genetic control of the immune response to a Plasmodium falciparum sporozoite vaccine: Widespread nonresponsiveness to single malaria epitope in highly repetitive vaccine in congenic mice
8. Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells: An in vitro assay of protective antibodies
9. Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. IV. Dose response, specificity and humoral immunity
10. Carrier-induced epitopic suppression, a major issue for future synthetic vaccines
11. Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. V. In vitro effects of immune serum on sporozoites
12. Structure of the circumsporozoite protein gene in 18 strains of Plasmodium falciparum
13. Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine
14. Ubiquity of the repetitive epitope of the CS protein in different isolates of human malaria parasites