Evidence that antagonism at non-NMDA receptors results in anticonvulsant action

European Journal of Pharmacology

Volumn 136, Issue 1, 1987, Pages 69-73

  Turski, Lechoslaw ^a   Meldrum, Brian S ^a   Turski, Waldemar A ^b   Watkins, Jeffrey C ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

(Mouse); 1 (p Bromobenzoyl) piperazine 2,3 dicarboxylic acid; Excitatory amino acid antagonists; Seizures; D Glutamylaminomethylsulphonic acid

Indexed keywords

1 (4 BROMOBENZOYL) 2,3 PIPERAZINEDICARBOXYLIC ACID; 2 AMINO 7 PHOSPHONOHEPTANOIC ACID; GAMMA DEXTRO GLUTAMYLAMINOMETHYLSULFONIC ACID; GAMMA GLUTAMYLAMINOMETHYLSULFONIC ACID; KAINIC ACID; N METHYLASPARTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; CONVULSION; DRUG EFFICACY; DRUG INTERACTION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTICONVULSANTS; ASPARTIC ACID; GLUTAMATES; INJECTIONS, INTRAVENTRICULAR; KAINIC ACID; MALE; MICE; N-METHYLASPARTATE; PIPERAZINES; RECEPTORS, AMINO ACID; RECEPTORS, CELL SURFACE; SUPPORT, NON-U.S. GOV'T;

EID: 0023248333     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(87)90780-1     Document Type: Article

References (11)

1. Antagonists at the N-methyl-D-aspartate receptor produce anticonflict effects
2. Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity
3. Anticonvulsant action of excitatory amino acid antagonists
4. γ-D-Glutamylaminomethylsulphonic acid (GAMS), a kainate and quisqualate antagonist, prevents sound-induced seizures in DBA/2 mice
5. Phosphono dipeptides and piperazine derivatives as antagonists of amino acid induced and synaptic excitation in mammalian and amphibian spinal cord
6. Depressant actions of γ-D-glutamylaminomethylsulfonate (GAMS) on amino acid-induced and synaptic excitation in the cat spinal cord
7. A simplified method of evaluating dose-effect experiments
8. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters
9. Anticonvulsant action of β-kainic acid in mice. Is β-kainic acid an N-methyl-D-aspartate antagonist?
10. Anticonvulsant action of stereoisomers of γ-glutamylaminomethylsulphonic acid in mice
11. Muscle relaxant action of excitatory amino acid antagonists