MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

Neuroscience Letters

Volumn 80, Issue 1, 1987, Pages 111-114

  Coan, E J ^a   Saywood, W ^a   Collingridge, G L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

(+) 5 Methyl 10,11 dihydro 5H dibenzo a,d cyclohepten 5,10 imine maleate (MK 801); Hippocampal slice; Long term potentiation; N Methyl d aspartate receptor; Neuroprotection; Synaptic transmission

Indexed keywords

ASPARTIC ACID; DIZOCILPINE;

ANIMAL CELL; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; DIBENZOCYCLOHEPTENES; DIZOCILPINE MALEATE; FEMALE; HIPPOCAMPUS; IN VITRO; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROTRANSMITTER; SUPPORT, NON-U.S. GOV'T; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 0023243319     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(87)90505-2     Document Type: Article

References (14)

1. Studies on the use-dependency of phencyclidine-like compounds as N-methylaspartate antagonists in vivo and in vitro
2. Anticonvulsant activity of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties
3. Magnesium ions block an N-methyl-d-aspartate receptor-mediated component of synaptic transmission in rat hippocampus
4. Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N-methyl-d-aspartate receptor mediated synaptic responses in rat hippocampal slices
5. NMDA receptors — their role in long-term potentiation
6. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
7. Systemic administration of MK-801 protects against ischaemia-induced hippocampal neurodegeneration in the gerbil
8. Anticonvulsant doses of MK-801 fail to block long-term potentiation in vivo or impair spatial memory in the rat
9. Possible therapeutic applications of antagonists of excitatory amino acid neurotransmission
10. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5
11. 3H]-d-AP5 binding sites in rat brain membranes
12. Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine
13. The anti-convulsant MK-801 is a potent N-methyl-d-aspartate antagonist