Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse

Journal of Experimental Medicine

Volumn 165, Issue 6, 1987, Pages 1639-1654

  Wicker, Linda S ^a   Miller, Beverly J ^a   Coker, Lisa Z ^a   McNally, Susan E ^b   Scott, Solomon ^b   Mullen, Yoko ^c   Appeli, Michael C ^d  

^a Immunology Research   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; AUTOIMMUNE DISEASE; DIABETES MELLITUS; DIABETOGENESIS; ENDOCRINE SYSTEM; ETIOLOGY; GENE CONTROL; GENETIC ENGINEERING; HEREDITY; INSULITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL;

ANIMALS; AUTOIMMUNE DISEASES; CROSSES, GENETIC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; HOMOZYGOTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED STRAINS; PANCREAS; PANCREATITIS; SEX FACTORS;

EID: 0023240892     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.165.6.1639     Document Type: Article

References (42)

1. Nerup, J., M. Christy, P. Platz, L. P. Ryder, and A. Svegaard. 1984. Aspects of the genetics of insulin-dependent diabetes mellitus. In Immunology of Diabetes. D. Andreani, V. DiMario, K. F. Federlin, and L. G. Heding, editors. Kimpton Medical Publications, London. 63-70.
2. Cudworth, A. G., and E. Wolf. 1984. Genetic basis of type I (insulin-dependent) diabetes. In Immunology of Clinical and Experimental Diabetes. S. Gupta, editor. Plenum Publishing Corp., New York. 271-294.
3. Owerbach, D., B. Hagglof, A. Lernmark, and G. Holmgren. 1984. Susceptibility to insulin-dependent diabetes defined by restriction enzyme polymorphism of HLA-D region genomic DNA. Diabetes. 33: 958.
4. Cohen-Haguenauer, O., E. Robbins, C. Massart, M. Busson, I. Deschamps, J. Hors, J.-M. Lalouel, J. Dausset, and D. Cohen. 1985. A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA. 82: 3335.
5. + seropositive juvenile rheumatoid arthritis. J Exp. Med. 164: 345.
6. Sheehy, M. J., J. R. Rowe, and M.J. MacDonald. 1985. A particular subset of HLA-DR4 accounts for all or most of the DR4 association in type 1 diabetes. Diabetes. 34: 942.
7. Sheehy, M. J., J. R. Rowe, T. C. Fuller, E.J. Yunis, and K. H. Gabby. 1985. A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes. Diabetologia. 28: 891.
8. Foulis, A. K., C. N. Liddle, M. A. Farquharson, J. A. Richmond, and R. S. Weir. 1986. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia. 29: 267.
9. Sutherland, D. E. R., R. Sibley, P. Chinn, A. Michael, S. Srikanta, F. Taub, J. Najarian, and F. C. Goetz. 1984. Twin-to-twin pancreas transplantation (TX): reversal and reenactment of the pathogenesis of type I diabetes. Clin. Res. 32:551a. (Abstr.)
10. Nakhooda, A. F., A. A. Like, C. I. Chappel, F. T. Murray, and E. B. Marliss. 1977. The spontaneously diabetic Wistar rat. Diabetes. 26:100.
11. Seemayer, T. A., L. L. Oligny, G. S. Tannenbaum, H. Goldman, and E. Colle. 1980. Animal model: spontaneous diabetes mellitus in the BB Wistar rat. Am. J. Pathol. 101: 485.
12. Makino, S., D. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri, and Y. Tochino. 1980. Breeding of a non-obese, diabetic strain of mice. Exp. Anim. (Tokyo). 29: 1.
13. Tochino, Y., T. Kanaya, and S. Makino. 1982. Genetics of NOD mice. In Clinico-Genetic Genesis of Diabetes Mellitus. G. Mimura, S. Baba, Y. Goto, and J. Kobberling, Eds. Excerpta Medica, Amsterdam. 285-291.
14. Fujita, T., R. Yui, Y. Kusumoto, Y. Serizawa, S. Makino, and Y. Tochino. 1982. Lymphocyte insulitis in a "non-obese diabetic (NOD)" strain of mice: an immunohis-tochemical and electron microscope investigation. Biomed. Res. 3: 429.
15. Kanazawa, Y., K. Komeda, S. Sato, S. Mori, K. Akanuma, and F. Takaku. 1984. Non-obese-diabetic mice: immune mechanisms of pancreatic B-cell destruction. Diabetologia. 27: 113.
16. Maruyama, T., I. Takei, M. Taniyama, K. Kataoka, and S. Matsuki. 1984. Immunological aspect of non-obese diabetic mice: immune islet cell-killing mechanism and cell-mediated immunity. Diabetologia. 27: 121.
17. Koevary, S., A. A. Rossini, W. Stoller, W. L. Chick, and R. M. Williams. 1983. Passive transfer of diabetes in the BB/W rat. Science (Wash. DC). 220: 727.
18. Like, A. A., E.J. Weringer, A. Holdash, P. McGill, D. Atkinson, and A. A. Rossini. 1985. Adoptive transfer of autoimmune diabetes mellitus in Biobreeding/Worcester (BB/W) inbred and hybrid rats. J. Immunol. 134: 1583.
19. Like, A. A., M. Anthony, D. L. Guberski, and A. A. Rossini. 1983. Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes. Diabetes. 32: 326.
20. Jackson, R., N. Rassi, T. Crump, B. Haynes, and G. S. Eisenbarth. 1981. The BB rat: profound T cell lymphocytopenia. Diabetes. 30: 887.
21. Colle, E., R. D. Guttmann, and T. Seemayer. 1981. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. J. Exp. Med. 154: 1237.
22. Jackson, R. A., J. B. Buse, R. Rifai, D. Pelletier, E. L. Milford, C. B. Carpenter, G. S. Eisenbarth, and R. M. Williams. 1984. Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses. J. Exp. Med. 159: 1629.
23. Like, A. A., D. L. Guberski, and L. Butler. 1986. Diabetic Biobreeding/Worcester (BB/Wor) rats need not be lymphopenic. J. Immunol. 136: 3254.
24. Wicker, L. S., B.J. Miller, and Y. Mullen. 1986. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes. 35: 855.
25. Wicker, L. S., B.J. Miller, and Y. Mullen. 1986. Transfer of autoimmune diabetes mellitus with T cells from nonobese diabetic mice. Transplant. Proc. 18: 809.
26. Kataoka, S., J. Satoh, H. Fujiya, T. Toyota, R. Suzuki, K. Itoh, and K. Kumagai. 1983. Immunologic aspects of the nonobese diabetic (NOD) mouse. Abnormalities of cellular immunity. Diabetes. 32: 247.
27. Hattori, M., J. B. Buse, R. A. Jackson, L. Glimcher, M. E. Dorf, M. Minami, S. Makino, K. Moriwake, H. Kuzuya, H. Imura, W. M. Strauss, J. G. Seidman, and G. S. Eisenbarth. 1986. The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science (Wash. DC). 231: 733.
28. Leiter, E. H., M. Prochazka, D. L. Coleman, D. V. Serreze, and L. D. Shultz. 1986. Genetic factors predisposing to diabetes susceptibility in mice. In The Immunology of Diabetes Mellitus: Proceedings of the International Symposium on the Immunology of Diabetes, Edmonton. 29-36
29. Mathis, D. J., C. Benoist, V. E. Williams II, M. Kanter, and H. O. McDevitt. 1983. Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc. Natl. Acad. Sci. USA. 80: 273.
30. d antibodies and an examination of expression of H-2d antigens on the surface of these cells. Transplantation (Baltimore). 34: 113.
31. Oi, V. T., P. P. Jones, J. W. Goding, L. A. Herzenberg, and L. A. Herzenberg. 1978. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and la antigens. Curr. Top. Microbiol. Immunol. 81: 115.
32. Silver, J., S. L. Swain, andj. J. Hubert. 1980. Small subunit of I-A subregion antigens determines the allospecificity recognized by a monoclonal antibody. Nature (Lond.). 286: 272.
33. Talal, N., and A. D. Steinberg. 1974. The pathogenesis of autoimmunity in New Zealand black mice. Curr. Top. Microbiol. Immunol. 64: 79.
34. Seemayer, T. A., and E. Colle. 1984. Pancreatic cellular infiltrates in autoimmune-prone New Zealand black mice. Diabetologia. 26: 310.
35. Benacerraf, B., and R. N. Germain. 1978. The immune response genes of the major histocompatibility complex. Immunol. Rev. 38: 70.
36. Korman, A. J., J. M. Boss, T. Spies, R. Sorrentino, K. Okada, and J. L. Strominger. 1985. Genetic complexity and expression of human class II histocompatibility antigens. Immunol. Rev. 85: 45.
37. Adorini, L., M. A. Harvey, A. Miller, and E. E. Sercarz. 1979. The fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme (HEL) in a genetically nonresponder mouse strain. J. Exp. Med. 150: 293.
38. b mice. Immunogenetics. 20: 535.
39. Sadegh-Nasseri, S., V. Dessi, and E. E. Sercarz. 1986. Selective reversal of H-2-linked genetic unresponsiveness to lysozymes. II. Alteration in the T helper/T suppressor balance, owing to gene(s) linked to Ir-2, leads to responsiveness in BALB.B. Eur. J. Immunol. 16: 486.
40. Krzych, U., G. B. Thurman, A. L. Goldstein, J. P. Bressler, and H. R. Strausser. 1979. Sex-related immunocompetence of Balb/c mice. I. Study of immunologic responsiveness of neonatal, weanling, and young adult mice. J. Immunol. 123: 2568.
41. Makino, S., K. Kunimoto, Y. Muraoka, and K. Katagiri. 1981. Effect of castration on the appearance of diabetes in NOD mouse. Exp. Anim. (Tokyo). 30: 137.
42. Harada, M., and S. Makino. 1984. Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide. Diabetologia. 27: 604.