Bone Sarcomas Linked to Radiotherapy and Chemotherapy in Children

New England Journal of Medicine

Volumn 317, Issue 10, 1987, Pages 588-593

  Tucker, Margaret A ^{a,b,c,d,e,f,g}   D'angio, Giulio J ^h   Boice, John D ^h   Strong, Louise C ^h   li, Frederick P ^h   Stovall, Marilyn ^h   Stone, Betty J ^h   Green, Daniel M ^h   Lombardi, Fabrizio ^h   Newton, William ^h   Hoover, Robert N ^h   Fraumeni, Joseph F ^h  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d Dana Foundation   (United States)

^e ROSWELL PARK CANCER INSTITUTE   (United States)

^f NATIONAL CANCER INSTITUTE   (Italy)

^g NATIONWIDE CHILDREN S HOSPITAL   (United States)

^h NONE

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CHEMOTHERAPY; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; EPIDEMIOLOGY; HUMAN; MAJOR CLINICAL STUDY; OSTEOSARCOMA; PRIORITY JOURNAL; RADIOTHERAPY; RISK; THERAPY;

EID: 0023239053     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198709033171002     Document Type: Article

References (31)

1. Martland HS. Occupational poisoning in manufacture of luminous watch dials. JAMA 1929; 92: 466–73.
2. Fraumeni JF Jr. Boice JD Jr. Bone. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer epidemiology and prevention. Philadelphia: W.B. Saunders, 1982:814–26.
3. Cahan WG, Woodard HQ, Higinbotham NL, Stewart AW, Coley BL. Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1948; 1: 3–29.
4. Huvos AG, Woodard HQ, Cahan WG, et al. Postradiation osteogenic sarcoma of bone and soft tissues: a clinicopathologic study of 66 patients. Cancer 1985; 55: 1244–55.
5. Meadows AT, Baum E, Fossati-Bellani F, et al. Second malignant neoplasms in children: an update from the Late Effects Study Group. J Clin Oncol 1985; 3: 532–8.
6. Abramson DH, Ellsworth RM, Kitchin FD, Tung G. Second nonocular tumors in retinoblastoma survivors: Are they radiation-induced? Ophthalmology 1984; 91: 1351–5.
7. Sagerman RH, Cassady JR, Tretter P, Ellsworth RM. Radiation induced neoplasia following external beam therapy for children with retinoblastoma. Am J Roentgenol Radium Ther Nucl Med 1969; 105: 529–35.
8. Strong LC, Herson J, Osborne BM, Sutow WW. Risk of radiation-related subsequent malignant tumors in survivors of Ewing's sarcoma. JNCI 1979; 62: 1401–6.
9. Greene MH, Glaubiger DL, Meade GD, Fraumeni JF Jr. Subsequent cancer in patients with Ewing's sarcoma. Cancer Treat Rep 1979; 63: 2043–6.
10. Li FP. Second malignant tumors after cancer in childhood. Cancer 1977; 40: 1899–902.
11. Draper GJ, Sanders BM, Kingston JE. Second primary neoplasms in patients with retinoblastoma. Br J Cancer 1986; 53: 661–71.
12. Meadows AT, Strong LC, Li FP, et al. Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic predisposition. Cancer 1980; 46: 2603–6.
13. Ron E, Modan B, Boice JD Jr. Mortality from cancer and other causes following radiotherapy for ringworm of the scalp. Am J Epidemiol (in press).
14. Tucker MA, Meadows AT, Boice JD Jr. Hoover RN, Fraumeni JF Jr. Cancer risk following treatment of childhood cancer. In: Boice JD Jr. Fraumeni JF Jr, eds. Radiation carcinogenesis: epidemiology and biological significance. New York: Raven Press, 1984:211–24.
15. Monson RR. Analysis of relative survival and proportional mortality. Cornput Biomed Res 1974; 7: 325–32.
16. Heston JF, Kelly JAB, Meigs JW. Flannery JT, Cusano MM. Young JL Jr. Forty-five years of cancer incidence in Connecticut: 1935–79. Natl Cancer Inst Monogr 1986; 70: 333.
17. Waterhouse J, Muir C, Correa P, Powell J, eds. Cancer incidence in five continents. Vol. III. Lyon, France: International Agency for Research on Cancer, 1976.
18. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457–81.
19. Lubin JH. A computer program for the analysis of matched case–control studies. Comput Biomed Res 1981; 14: 138–43.
20. Rothman KJ, Boice JD Jr. Epidemiologic analysis with a programmable calculator. Boston: Epidemiology Resources. 1982.
21. Stovall M. Organ doses from radiotherapy of cancer of the uterine cervix. In: Day NE, Boice JD Jr, eds. Second cancer in relation to radiation treatment for cervical cancer: results of a cancer registry collaboration. New York: Oxford University Press, 1984:131–5.
22. Tucker MA, Meadows AT, Boice JD Jr, et al. Leukemia after therapy with alkylating agents for childhood cancer. JNCI 1987; 78: 459–64.
23. Sieber SM, Correa P, Dalgard DW, Adamson RH. Carcinogenic and other adverse effects of procarbazine in nonhuman primates. Cancer Res 1978; 38: 2125–34.
24. Boice JD Jr. Day NE, Andersen A, et al. Second cancers following radiation treatment for cervical cancer: an international collaboration among cancer registries. JNCI 1985; 74: 955–75.
25. Potish RA, Dehner LP, Haselow RE, Kim TH, Levitt SH, Nesbit M. The incidence of second neoplasms following megavoltage radiation for pediatric tumors. Cancer 1985; 56: 1534–7.
26. Hansen MF, Koufos A. Gallie BL, et al. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci USA 1985; 82: 6216–20.
27. Li FP, Fraumeni JF Jr. Soft-tissue sarcomas, breast cancer, and other neoplasms: A familial syndrome? Ann Intern Med 1969; 71: 747–52.
28. Williams WR, Strong LC, Norsted TL. Genetic epidemiology of childhood soft tissue sarcoma (STS). Proc Am Assoc Cancer Res 1985; 26: 208. abstract.
29. Mays CW, Spiess H. Bone sarcomas in patients given radium-224. In: Boice JD Jr, Fraumeni JF Jr, eds. Radiation carcinogenesis: epidemiology and biological significance. New York: Raven Press, 1984:241–52.
30. Committee on the Biological Effects of Ionizing Radiations. The effects on populations of exposure to low levels of ionizing radiation: 1980. Washington, D.C.: National Academy Press, 1980.
31. Greene MH, Harris EL, Gershenson DM, et al. Melphalan may be a more potent leukemogen than cyclophosphamide. Ann Intern Med 1986; 105: 360–7.