Multiple-Drug Resistance in Human Cancer

New England Journal of Medicine

Volumn 316, Issue 22, 1987, Pages 1388-1393

  Flier, Jeffrey S ^a   Underhill, Lisa H ^a   Pastan, Ira ^a   Gottesman, Michael ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CARMUSTINE; COLCHICINE; CYCLOPHOSPHAMIDE; CYTARABINE; DACTINOMYCIN; DAUNORUBICIN; DEXAMETHASONE; DILTIAZEM; DNA; DOXORUBICIN; ETOPOSIDE; METHOTREXATE; MITHRAMYCIN; QUINIDINE; RADIOISOTOPE; RESERPINE; RNA; TENIPOSIDE; TIOGUANINE; VERAPAMIL; VINBLASTINE; VINCRISTINE;

CANCER; CANCER CHEMOTHERAPY; CELL STRAIN KB; DRUG BINDING; DRUG COMPARISON; DRUG MECHANISM; DRUG RESISTANCE; GENE AMPLIFICATION; GENETIC ANALYSIS; GENETIC ENGINEERING; HEREDITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; SHORT SURVEY; SOFT TISSUE; THERAPY;

ANTINEOPLASTIC AGENTS; CELLS, CULTURED; DRUG RESISTANCE; GENE AMPLIFICATION; HUMAN; NEOPLASMS;

EID: 0023233801     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198705283162207     Document Type: Review

References (38)

1. Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science 1978; 202: 1051–5.
2. Ling V. Multidrug-resistant mutants. In: Gottesman MM, ed. Molecular cell genetics. New York: John Wiley. 1985:773–87.
3. Biedler J, Peterson RHF. Altered plasma membrane glycoconjugates of Chinese hamster cells with acquired resistance to actinomycin D, daunorubicin, and vincristine. In: Sartorelli achéal. Bertino JR, Lazo JS, eds. Molecular actions and targets for cancer chemotherapeutic agents. New York: Academic Press, 1981:453–82.
4. Ling V, Thompson LH. Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J Cell Physiol 1974; 83: 103–16.
5. Kartner N, Riordan JR, Ling V. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 1983; 221: 1285–8.
6. Inaba M, Kobayashi H. Sakurai Y, Johnson RK. Active efflux of daunorubicin and Adriamycin in sensitive and resistant sublines of P388 leukemia. Cancer Res 1979; 39: 2200–3.
7. Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Increased accumulation of vincristine and Adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res 1982; 42: 4730–3.
8. Akiyama S-i, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somatic Cell Mol Genet 1985; 11: 117–26.
9. Shen D-w, Cardarelli C, Hwang J, et al. Multiply drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. J Biol Chem 1986; 261: 7762–70.
10. Fojo A, Akiyama S-i, Gottesman MM, Pastan I. Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. Cancer Res 1985; 45: 3002–7.
11. Willingham MC, Cornwell MM, Cardarelli CO, Gottesman MM, Pastan I. Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and sensitive KB cells: effects of verapamil and other drugs. Cancer Res 1986; 46: 5941–6.
12. Cornwell MM, Gottesman MM, Pastan IH. Increased, vinblastine binding to membrane vesicles from multidrug-resistant KB cells. J Biol Chem 1986; 261: 7921–8.
13. Cornwell MM, Safa AR, Felsted RL. Gottesman MM, Pastan I. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150-to 170-kDa protein detected by photoaffinity labeling. Proc Natl Acad Sci USA 1986; 83: 3847–50.
14. Cornwell MM, Pastan I, Gottesman MM. Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem 1987; 262: 2166–70.
15. Shen D-W, Fojo A, Roninson IB, et al. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol 1986; 6: 4039–44.
16. Siminovitch L. Mechanisms of genetic variation in Chinese hamster ovary cells. In: Gottesman MM, ed. Molecular cell genetics, New York: John Wiley, 1985:869–79.
17. Fojo AT, Whang-Peng J, Gottesman MM, Pastan I. Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA 1985; 82: 7661–5.
18. Yeung C-Y, Ingolia DE, Bobonis C, et al. Selective overproduction of adenosine deaminase in cultured mouse cells. J Biol Chem 1983; 258: 8338–45.
19. Roninson IB. Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels. Nucleic Acids Res 1983; 11: 5413–31.
20. Roninson IB, Abelson HT, Housman DE, Howell N. Varshavsky A. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature 1984; 309: 626–8.
21. Gros P. Croop J. Roninson I. Varshavsky A, Housman DE. Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci USA 1986; 83: 337–41.
22. Roninson IB, Chin JE, Choi K, et al. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA 1986; 83: 4538–42.
23. Shen D-w, Fojo A, Chin JE, et al. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science 1986; 232: 643–5.
24. Rogan AM, Hamilton TC, Young RC, Klecker RW Jr, Ozols RF. Reversal of adriamycin resistance by verapamil in human ovarian cancer. Science 1984; 224: 994–6.
25. Beck WT. Mueller TJ. Tanzer LR. Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts. Cancer Res 1979; 39: 2070–6.
26. Fojo AT, Ueda K, Slamon DJ, et al. Expression of a multidrug resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 1987; 84: 265–9.
27. Gros P. Ben Neriah Y. Croop JM, Housman DE. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 1986; 323: 728–31.
28. Ueda K, Cardarelli C, Gottesman MM, Pastan I. Expression of a full-length cDNA for the human mdr1 (P-glycoprotein) gene confers multidrug-resistance in mouse and human cells. Proc Natl Acad Sci USA 1987; 84: 3004–8.
29. Kartner N, Evernden-Porelle D, Bradley G, Ling V. Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 1985; 316: 820–3.
30. Riordan JR, Duechars K, Kartner N, Alon N, Trent J, Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 1985; 316: 817–9.
31. Van der Bliek AM, Van der Velde-Koerts T, Ling V, Borst P. Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol 1986; 6: 1671–8.
32. Scotto KW, Biedler JL, Melera PW. Amplification and expression of genes associated with multidrug resistance in mammalian cells. Science 1986; 232: 751–5.
33. Ueda K, Cornwell MM, Gottesman MM, et al. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun 1986; 141: 956–62.
34. Ueda K, Clark DP, Chen C-j, Roninson IB, Gottesman MM, Pastan 1. The human multidrug resistance {mdr1) gene: cDNA cloning and transcription initiation. J Biol Chem 1987; 262: 505–8.
35. Chen C-j, Chin JE, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986; 47: 381–9.
36. Higgins CF, Hiles ID, Salmond GPC, et al. A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria. Nature 1986; 323: 448–50.
37. Gros P. Croop J, Housman D. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 1986; 47: 371–80.
38. Gerlach JH, Endicott JA, Juranka PF, et al. Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature 1986; 324: 485–9.