Treatment of Primary Moderate Hypercholesterolemia With Lovastatin (Mevinolin) and Colestipol

JAMA: The Journal of the American Medical Association

Volumn 257, Issue 1, 1987, Pages 33-38

  Vega, Gloria Lena ^a   Grundy, Scott M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLESTIPOL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN;

BLOOD AND HEMOPOIETIC SYSTEM; DRUG EFFICACY; DRUG MIXTURE; HUMAN; HUMAN EXPERIMENT; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; THERAPY;

AGED; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEINS; CLINICAL TRIALS; COLESTIPOL; DRUG THERAPY, COMBINATION; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; KINETICS; LIPIDS; LIPOPROTEINS, HDL CHOLESTEROL; LIPOPROTEINS, LDL CHOLESTEROL; LOVASTATIN; MALE; MIDDLE AGE; NAPHTHALENES; POLYAMINES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023232731     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1987.03390010037024     Document Type: Article

References (29)

1. Goldstein JL, Brown MS: LDL receptor defect in familial hypercholesterolemia. Med Clin North Am 1982;66:335-364.
2. Lowering blood cholesterol to prevent heart disease, CONSENSUS CONFERENCE. JAMA 1985; 253:2080-2086.
3. Endo A, Kurodo M, Tsujita G: ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterol-genesis produced by Penicillium citrinum. J Antibiot 1976;29:1346-1348.
4. Bilheimer DW, Grundy SM, Brown MD, et al: Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Proc Natl Acad Sci USA 1983;80:4124-4128.
5. Illingworth DR, Sexton GJ: Hypocholesterolemia effects of mevinolin in patients with heterozygous familial hypercholesterolemia. J Clin Invest 1984;74:1972-1978.
6. Grundy SM, Vega GL: Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia. J Lipid Res 1985; 26:1464-1475.
7. Illingworth DR: Mevinolin plus colestipol in therapy for severe heterozygous familial hypercholesterolemia. Ann Intern Med 1984;101:598-604.
8. Grundy SM, Vega GL, Bilheimer DW: Influence of combined therapy with mevinolin and interruption of bile acid reabsorption on low density lipoproteins in heterozygous familial hypercholesterolemia. Ann Intern Med 1985;103:339-343.
9. Nora JJ, Lortscher RM, Spangler RD, et al: I. Familial hypercholesterolemia with ’normal’ cholesterol in obligate heterozygotes. Am J Med Genet 1985;22:585-591.
10. Brown MD, Goldstein JL: The hyperlipoproteinemias and other disorders of lipid metabolism, in Isselbacher KJ, Adams RD, Braunwald E, et al. (eds): Harrison’s Principles of Internal Medicine, ed 9. New York, McGraw-Hill International Book Co, 1980, pp 507-517.
11. Vega GL, Beltz WF, Grundy SM: Low density lipoprotein metabolism in hypertriglyceridemic and normolipidemic patients with coronary heart disease. J Lipid Res 1985;26:115-126.
12. McFarlane AS: Efficient trace-labeling of proteins with iodine. Nature 1958;182:53.
13. Bilheimer DW, Eisenberg S, Levy RI: The metabolism of very low density lipoproteins proteins: I. Preliminary in vitro and in vivo observations. Biochim Biophys Acta 1972;260:212-221.
14. Matthews CME: The theory of tracer experiments with iodine 131-labeled plasma proteins. Phys Med Biol 1957;2:36-53.
15. Grundy SM, Vega GL, Bilheimer DW: Kinetic mechanism determining variability in low density lipoprotein levels and their rise with age. Arteriosclerosis 1985;5:623-630.
16. Heiss G, Tamir I, David CE, et al: Lipoprotein-cholesterol distributions in selected North American populations: The Lipid Research Clinics Program prevalence study. Circulation 1980;61: 302-315.
17. Lipid Research Clinics Program: The Lipid Research Clinics coronary primary prevention trial results: II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 1984;251:365-374.
18. Neaton JD, Kuller LH, Wentworth D, et al: Total cardiovascular mortality in relation to cigarette smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for five years. Am Heart J 1984; 108:759-769.
19. Goldstein JL, Hazzard WR, Schrott HG, et al: Hyperlipidemia in coronary heart disease: I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest 1973;52:1533-1543.
20. Goldstein JL, Schrott HG, Hazzard WR, et al: Hyperlipidemia in coronary heart disease: II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest 1973;52:1544-1568.
21. Brown MS, Goldstein JL: Lipoprotein receptors in the liver: Control signals for plasma cholesterol traffic. J Clin Invest 1983;72:743-747.
22. Campeau L, Enjalbert M, Lesperance J, et al: The relation of risk factors to the development of atherosclerosis in saphenous vein bypass grafts and progession of disease in the native circulation. N Engl J Med 1984;311:1329-1332.
23. Kannel WB, Castelli WP, Gordon T: Cholesterol in the prediction of atherosclerotic disease: New perspectives based on the Framingham Study. Ann Intern Med 1979;90:85-91.
24. Vlietstra RE, Frye RL, Kronmal RA, et al: Risk factors and angiographic coronary artery disease: A report from the Coronary Artery Surgery Study (CASS). Circulation 1980;62:254-261.
25. Havel RJ, Hunninghake DB, Illingworth R, et al: Mevinolin in therapy of familial hypercholesterolemia. Circulation 1985;72:111-198.
26. Witztum JL, Schonfeld G, Wiedman SW, et al: Bile sequestrant therapy alters the composition of low density and high density lipoproteins. Metabolism 1979;28:221-229.
27. Witztum JL, Young SG, Elam RL, et al: Cholestyramine-induced changes in low density lipoprotein composition and metabolism: I. Studies in the guinea pig. J Lipid Res 1985;26:92-103.
28. Kesaniemi YA, Grundy SM: Turnover of low density lipoproteins during inhibition of cholesterol absorption by neomycin. Arteriosclerosis 1984; 4:41-47.
29. Castelli WP, Abbott RD, McNamara PM: Summary estimates of cholesterol used to predict coronary heart disease. Circulation 1983;67:730-734.