The inflammatory effect of nucleus pulposus: A possible element in the pathogenesis of low-back pain

Spine

Volumn 12, Issue 8, 1987, Pages 760-764

  McCarron, Robert F ^a   Wimpee, Marc W ^a   Hudkins, Philip G ^a   Laros, Gerald S ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Inflammatory reaction; Low back pain; Neural elements; Nuclear material

Indexed keywords

ANIMAL EXPERIMENT; BONE; CARTILAGE; DOG; ETIOLOGY; JOINT; LOW BACK PAIN; MUSCULOSKELETAL SYSTEM; NONHUMAN; NUCLEUS PULPOSUS; PATHOGENESIS; PERIPHERAL NERVOUS SYSTEM;

ANIMAL; BACK PAIN; DOGS; DURA MATER; FEMALE; INTERVERTEBRAL DISK DISPLACEMENT; MALE; MENINGITIS;

EID: 0023226602     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/00007632-198710000-00009     Document Type: Article

References (24)

1. Akeson WH, Woo SL, Taylor TKF, G, Ghosh P, Bushell GR: Biomechanics and biochemistry of the intervertebral disk. Clin Orthop 129:133-140, 1977
2. Boros DL: Granulomatous inflammation. Prog Allergy 24:184, 1978
3. Braun IF, Lin JR, Benjamin MU, Kriecheflfll: Computed tomography of the asymptomatic postsurgical lumbar spine: Analysis of the physiologic scar. AJR 142:149-152, 1984
4. Crock HV: Practice of Spinal Surgery. New York, Springer-Verlag, 1983
5. Femstrom U: Discographical study of ruptured lumbar intervertebral discs. Acta Chir Scand [Suppl] 258, 1960
6. Femstrom V: Disk rupture with surgical observations. Acta Chir Scand [Suppl] 258, 1960
7. Halperin N, Agasi M, Hendel D: Painless root compression following disc extrusion. Arch Orthop Trauma Surg 101:63-66, 1982
8. Gerbstein SD, Tyle M, Gross A: Autoimmunity in degenerative disc disease of the lumbar spine. Orthop Clin North Am 6:67, 1975
9. Heavner JE: Personal communication, 1984
10. Kelsey JL, White AA: Epidemiology and impact of low-back pain. Spine 5:133-142, 1980
11. Kelly M: Is pain due to pressure of nerves? Neurology 6:32-36, 1956
12. Kirkaldy-Willis WH: The relationship of structural pathology to the nerve root. Spine 9:49-52, 1984
13. Kirkaldy-Willis WH: Managing low back pain. New York, Churchill Livingstone, 1983
14. Lipson SJ, Muir H: Proteoglycans in experimental intervertebral disc degeneration. Spine 6:194-210, 1981
15. Macnab I: The Mechanism of Spondylogenic Pain in Cervical Pain. Edited by C Hirsch and Y Zoherman. Oxford, Pergamon Press, 1971, pp 89-95
16. McCulloch JA, Macnab I: Sciatica and Chymopapain. Baltimore, Williams and Wilkins, 1983, pp 191-195
17. Marshall LL, Trethewie ER, Curtain CC: Chemical radiculitis. Clin Orthop 129:61-67, 1977
18. Marshall L, Trethewie ER: Chemical irritation of nerve-root in Disc prolapse. Lancet 2:320, 1973
19. Naylor A, Happey F, Turner RL, et al: Enzymatic and immunological activity in the intervertebral disc. Orthop Clin North Am 6:51-58,1975
20. Postlethwaite AE, Jackson BK, Beachy EH, Kang AH: Formation of multinucleated giant cells from human monocyte precursors: Mediation by a soluble protein from antigen- and mitogen-stimulated lymphocytes. J Exp Med 155:168, 1982
21. Racz GB, Sabonghy M, Guintaulas J, Kline WM: Intractable pain therapy using a new epidural catheter. JAMA 248:579-581, 1982
22. Ryan GB, Spector WG: Macrophage turnover in inflamed connective tissue. Proc R Soc Lond [Biol] 174:269, 1970
23. Smyth MJ, Wright V: Sciatica and the intervertebral disc. J Bone Joint Surg 40A:1401-1418, 1958
24. Wahl SM, Wahl LM: Modulation of fibroblast growth and function by monokines and lymphokines. In: Lymphokines. Edited by E. Pick. New York, Academic Press, 1981, pp 179-201