Insulin Resistance in Essential Hypertension

New England Journal of Medicine

Volumn 317, Issue 6, 1987, Pages 350-357

  Ferrannini, Eleuterio ^a   Buzzigoli, Giuseppe ^a   Bonadonna, Riccardo ^a   Giorico, Maria Antonietta ^a   Oleggini, Marco ^a   Graziadei, Linda ^a   Pedrinelli, Roberto ^a   Brandi, Luigi ^a   Bevilacqua, Stefano ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; CARDIOVASCULAR SYSTEM; CLINICAL ARTICLE; ENDOCRINE SYSTEM; ESSENTIAL HYPERTENSION; ETIOLOGY; GLUCOSE OXIDATION; HUMAN; INSULIN RESISTANCE; PRIORITY JOURNAL;

EID: 0023191508     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198708063170605     Document Type: Article

References (48)

1. Havlik RJ, Hubert HB, Fabsitz RR, Feinleib M. Weight and hypertension. Ann Intern Med 1983; 98: 855–9.
2. MacMahon SW, Blacket RB, Macdonald GJ, Hall W. Obesity, alcohol consumption and blood pressure in Australian men and women: the National Heart Foundation of Australia Risk Factor Prevalence Study. J Hypertens 1984; 2: 85–91.
3. Stamler R, Stamler J, Reidlinger WF, Algera G, Roberts RH. Weight and blood pressure: findings in hypertension screening of 1 million Americans. JAMA 1978; 240: 1607–10.
4. Golay A, Felber JP, Dusmet M, Gomez F, Curchod B, Jéquier E. Effect of weight loss on glucose disposal in obese and obese diabetic patients. Int J Obes 1985; 9: 181–90.
5. Reisin E, Abel R, Modan M, Silverberg DS, Eliahou HE, Modan B. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med 1978; 298: 1–6.
6. MacMahon SW, Macdonald GJ, Bernstein L, Andrews G, Blacket RB. Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients. Lancet 1985; 1: 1233–6.
7. Modan M. Halkin H. Almog S, et al. Hyperinsulinemia: a link between hypertension obesity and glucose intolerance. J Clin Invest 1985; 75: 809–17.
8. Olefsky JM, Kolterman OG, Scarlett JA. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol 1982; 243: E15–E30.
9. DeFronzo RA, Ferrannini E. The pathogenesis of non-insulin-dependent diabetes: an update. Medicine (Baltimore) 1982; 61: 125–40.
10. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237; E214–E223.
11. Ferrannini E, Del Prato S, DeFronzo RA. Glucose kinetics: tracer methods. In: Clarke WL, Lamer J, Pohl SL, eds. Methods in diabetes research. Vol. II: Clinical methods. New York: John Wiley, 1986:107–42.
12. Jéquier E. Direct and indirect calorimetry in man. In: Garrow JS, Halliday D, eds. Substrate and energy metabolism. London: John Wiley, 1985:8292.
13. Metropolitan Life Insurance Company. In: Geigy scientific tables. 6th ed. Ardsley, N.Y.: Geigy Pharmaceuticals, 1962:623.
14. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979; 28: 1039–57.
15. Hume R. Prediction of lean body mass from height and weight. J Clin Pathol 1966; 19: 389–91.
16. McGuire EAH, Helderman JH, Tobin JD, Andres R, Berman M. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 1976; 41: 565–73.
17. Jones NL. Evaluation of a microprocessor-controlled exercise testing system. J Appl Physiol 1984; 57: 1312–8.
18. Brandi LS, Frediani M, Oleggini M, Mosca F, Ferrannini E. Evaluation of a computerized, open circuit canopy system for indirect calorimetry. Riv Ital NutrParEnt 1986; 4: 145–52.
19. Bevilacqua S, Bonadonna R, Buzzigoli G, et al. Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism 1987; 36: 502–6.
20. Hawk PB, Oser BL, Summerson WH. Practical physiological chemistry. 12th ed. Toronto: Blakiston, 1947:814–22.
21. Malvano R, Zucchelli GC, Rosa U, Salvetti A. Measurement of plasma renin activity by angiotensin I radioimmunoassay. I. An assessment of some methodological aspects. J Nucl Biol Med 1972; 16: 24–31.
22. Pilo A, Ferrannini E, Bjorkman O, et al. Analysis of glucose production and disappearance rates following an oral glucose load in normal subjects: a double tracer approach. In: Cobelli C, Bergman RN, eds. Carbohydrate metabolism: quantitative physiology and mathematical modelling. London: John Wiley, 1981:221–8.
23. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 1959; 82: 420–30.
24. Cobelli C, Mari A, Ferrannini E. The non-steady state problem: error analysis of Steele's model and new developments for glucose kinetics. Am J Physiol 1987; 252: E679–E689.
25. Ferrannini E, Smith JD, Cobelli C, Toffolo G, Pilo A, DeFronzo RA. Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest 1985; 76: 357–64.
26. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55: 628–34.
27. Ferrannini E. The theoretical bases of indirect calorimetry. Metabolism (in press).
28. DeFronzo RA, Ferrannini E, Hendler R, Feiig P, Wahren J. Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 1983; 32: 35–45.
29. Scheinberg P. Observations on cerebral carbohydrate metabolism in man. Ann Intern Med 1965; 62: 367–71.
30. Karam JH, Grodsky GM, Forsham PH. Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. J Am Diet Assoc 1963; 12: 197–204.
31. Rizza RA, Mandarino LJ, Genest J, Baker BA, Gerich JE. Production of insulin resistance by hyperinsulinaemia in man. Diabetologia 1985; 28: 70–5.
32. Rabinowitz D, Zierler KL. Forearm metabolism in obesity and its response to intra-arterial insulin: characterization of insulin resistance and evidence for adaptive hyperinsulinism. J Clin Invest 1962; 41: 2173–81.
33. Bratusch-Marrain PR, Smith D, DeFronzo RA. The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metab 1982; 55: 973–82.
34. Rizza RA, Mandarino LJ, Gerich JE. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 1982; 54: 131–8.
35. Rizza RA, Cryer PE, Haymond MW, Gerich JE. Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest 1980; 65: 682–9.
36. Mondon CE, Dolkas CB, Reaven GM. The site of insulin resistance in acute uremia. Diabetes 1978; 27: 571–6.
37. DeFronzo RA, Smith D, Alvestrand A. Insulin action in uremia. Kidney Int 1983; 24: Suppl 16: S-102-S-114.
38. DeFronzo RA. The effect of insulin on renal sodium metabolism: a review with clinical implications. Diabetologia 1981; 21: 165–71.
39. Silverberg AB, Shah SD, Haymond MW, Cryer PE. Norepinephrine: hormone and neurotransmitter in man. Am J Physiol 1978; 234: E252–E256.
40. Buhler FR, Kiowski W, Landmann R, et al. Changing role of beta- and alpha-adrenoreceptor-mediated cardiovascular responses in the transition from a high-cardiac output into a high-peripheral resistance phase in essential hypertension. In: Laragh JH, Bühler FR, Seldin DW, eds. Frontiers in hypertension research. New York: Springer-Verlag, 1981:316–26.
41. Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L. Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man. Diabetes 1981; 30: 219–25.
42. Landsberg L, Young JB. Insulin-mediated glucose metabolism in the relationship between dietary intake and sympathetic nervous system activity. Int J Obes 1985; 9: Suppl 2: 63–8.
43. Hilton PJ. Cellular sodium transport in essential hypertension. N Engl J Med 1986; 314: 222–9.
44. Ahmed K, Thomas BS. The effects of long chain fatty acids on sodium plus potassium ion-stimulated adenosine triphosphatase of rat brain. J Biol Chem 1971; 246: 103–9.
45. Tamura M, Kuwano H, Kinoshita T, Inagami T. Identification of linoleic and oleic acids as endogenous Na+, K+-ATPase inhibitors from acute volume-expanded hog plasma. J Biol Chem 1985; 260: 9672–7.
46. Bidard J-N, Rossi B, Renaud J-F, Lazdunski M. A search for an 'ouabain-like' substance from the electric organ of Electrophorus electricus which led to arachidonic acid and related fatty acids. Biochim Biophys Acta 1984; 769: 245–52.
47. Ng LL, Hockaday TDR. Non-esterified fatty acids may regulate human leucocyte sodium pump activity. Clin Sci 1986; 71: 737–42.
48. Clausen T. Regulation of active Na+-K+ transport in skeletal muscle. Physiol Rev 1986; 66: 542–80.