Association between Lupus Psychosis and Antiribosomal P Protein Antibodies

New England Journal of Medicine

Volumn 317, Issue 5, 1987, Pages 265-271

  Bonfa, Eloisa ^a,b   Golombek, Steven J ^a,b   Kaufman, Lee D ^a,b   Skelly, Susan ^a,b   Weissbach, Herbert ^a,b   Brot, Nathan ^a,b   Elkon, Keith B ^a,b  

^a Department of Obstetrics Gynecology   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; RIBOSOME PROTEIN P; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; HUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; PSYCHOSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0023177710     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198707303170503     Document Type: Article

References (38)

1. Christian CL, Elkon KB. Autoantibodies to intracellular proteins: clinical and biologic significance. Am J Med 1986; 80: 53–61.
2. Tan EM, Schur PH, Carr RI, Kunkel HG. Deoxyribonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus. J Clin Invest 1966; 45: 1732–40.
3. Koffler D, Schur PH, Kunkel HG. Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med 1968; 126: 607–24.
4. Reichlin M, Wasicek CA. Clinical and biologic significance of antibodies to Ro/SSA. Hum Pathol 1983; 14: 401–5.
5. Estes D, Christian CL. The natural history of systemic lupus erythematosus by prospective analysis. Medicine (Baltimore) 1971; 50: 85–95.
6. Feinglass EJ, Arnett FC, Dorsch CA, Zizic TM, Stevens MB. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore) 1976; 55: 323–39.
7. Gibson T, Myers AR. Nervous system involvement in systemic lupus erythematosus. Ann Rheum Dis 1976; 35: 398–406.
8. Appenzeller O, Williams RC Jr. Cerebral lupus erythematosus. Ann Intern Med 1979; 90: 430–1.
9. Kassan SS, Lockshin MD. Central nervous system lupus erythematosus: the need for classification. Arthritis Rheum 1979; 22: 1382–5.
10. Zvaifler NJ, Bluestein HG. The pathogenesis of central nervous system manifestations of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 862–6.
11. Harris EN, Hughes GRV. Cerebral disease in systemic lupus erythematosus. Springer Semin Immunopathol 1985; 8: 251–66.
12. Bluestein HG, Williams GW, Steinberg AD. Cerebrospinal fluid antibodies to neuronal cells: association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med 1981; 70: 240–6.
13. Hadler NM, Gerwin RD, Frank MM, Whitaker JN, Baker M, Decker JL. The fourth component of complement in the cerebrospinal fluid in systemic lupus erythematosus. Arthritis Rheum 1973; 16: 507–21.
14. Small P, Mass MF, Kohler PF, Harbeck RJ. Central nervous system involvement in SLE: diagnostic profile and clinical features. Arthritis Rheum 1977; 20: 869–78.
15. Elkon KB, Parnassa AP, Foster CL. Lupus autoantibodies target ribosomal P proteins. J Exp Med 1985; 162: 459–71.
16. Bonfa E, Elkon KB. Clinical and serologic associations of the antiribosomal P protein antibody. Arthritis Rheum 1986; 29: 981–5.
17. Elkon K, Skelly S, Parnassa AP, et al. Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus. Proc Natl Acad Sci USA 1986; 83: 7419–23.
18. Golombek SJ, Graus F, Elkon KB. Autoantibodies in the cerebrospinal fluid of patients with systemic lupus erythematosus. Arthritis Rheum 1986; 29: 1090–7.
19. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271–7.
20. Elkon KB, Culhane L. Partial immunochemical characterization of the Ro and La proteins using antibodies from patients with sicca syndrome and lupus erythematosus. J Immunol 1984; 132: 2350–6.
21. Elkon KB, Jankowski PW. Fine specificities of autoantibodies directed against the Ro, La, Sm, RNP, and Jo-1 proteins defined by two-dimensional gel electrophoresis and immunoblotting. J Immunol 1985; 134: 3819–24.
22. Kurata N, Tan EM. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis. Arthritis Rheum 1976; 19: 574–80.
23. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc Natl Acad Sci USA 1979; 76: 4350–4.
24. Aarden LA, de Groot ER, Feltkamp TEW. Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann NY Acad Sci 1975; 254: 505–15.
25. Koike T, Nagasawa R, Nagata N, Shirai T. Specificity of mouse hybridoma antibodies to DNA. Immunol Lett 1982; 4: 93–7.
26. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965; 2: 235–54.
27. Avrameas S. Coupling of enzymes to proteins with glutaraldehyde: use of the conjugates for the detection of antigens and antibodies. Immunochemistry 1969; 6: 43–52.
28. Elkon KB, Gharavi AE, Patel BM, Hughes GRV, Frankel A. IgA and IgM rheumatoid factors in serum, saliva and other secretions: relationship to immunoglobulin ratios in systemic sicca syndrome and rheumatoid arthritis. Clin Exp Immunol 1983; 52: 75–84.
29. Venables PJW, Smith PR, Maini RN. Purification and characterization of the Sjögren's syndrome A and B antigens. Clin Exp Immunol 1983; 54: 731–8.
30. Billings PB, Hoch SO. Isolation of intact Sm/RNP antigens from rabbit thymus. J Immunol 1983; 131: 347–51.
31. Wolin SL, Steitz JA. The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 1984; 81: 1996–2000.
32. Pincus T, Schur PH, Rose JA, Decker JL, Talal N. Measurement of serum DNA-binding activity in systemic lupus erythematosus. N Engl J Med 1969; 281: 701–5.
33. Quismorio FP, Friou GJ. Antibodies reactive with neurons in SLE patients with neuropsychiatric manifestations. Int Arch Allergy Appl Immunol 1972; 43: 740–8.
34. Bresnihan B, Oliver M, Williams B, Hughes GRV. An antineuronal antibody cross-reacting with erythrocytes and lymphocytes in systemic lupus erythematosus. Arthritis Rheum 1979; 22: 313–20.
35. Sege K, Peterson PA. Use of anti-idiotypic antibodies as cell-surface receptor probes. Proc Natl Acad Sci USA 1978; 75: 2443–7.
36. Cleveland WL, Wasserman NH, Sarangarajan R, Penn AS, Erlanger BF. Monoclonal antibodies to the acetylcholine receptor by a normally functioning auto-anti-idiotypic mechanism. Nature 1983; 305: 56–7.
37. Inoue T, Okamura M, Amatsu K, Ohe A, Kato N, Kanayama Y. Antineuronal antibodies in brain tissue of patient with systemic lupus erythematosus. Lancet 1982; 1: 852.
38. Graus F, Elkon KB, Cordon-Cardo C, Posner JB. Sensory neuronopathy and small cell lung cancer: antineuronal antibody that also reacts with the tumor. Am J Med 1986; 80: 45–52.