Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

Nature

Volumn 326, Issue 6108, 1987, Pages 73-77

  Dixon, Richard A F ^a   Sigal, Irving S ^a   Rands, Elaine ^a   Register, R Bruce ^a   Candelore, Mari Rios ^a   Blake, Allan D ^a   Strader, Catherine D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; ADRENALIN; AMINO ACID DERIVATIVE; BETA ADRENERGIC RECEPTOR; CHOLINERGIC RECEPTOR; CYANOPINDOLOL I 125; ISOPRENALINE; LIGAND; NORADRENALIN; OPSIN; RADIOISOTOPE; RETINAL; RHODOPSIN;

ANIMAL CELL; BIRD; BLOOD AND HEMOPOIETIC SYSTEM; CATTLE; DRUG ANALYSIS; DRUG BINDING; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG RECEPTOR BINDING; GENE EXPRESSION; GENETIC ENGINEERING; HEREDITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PHARMACOKINETICS; PRIORITY JOURNAL; SWINE;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; CRICETINAE; EPINEPHRINE; HUMANS; IODOCYANOPINDOLOL; ISOPROTERENOL; MUTATION; NOREPINEPHRINE; PINDOLOL; RECEPTORS, ADRENERGIC, BETA; RHODOPSIN; TRANSFECTION;

ANIMALIA; AVES; BOS TAURUS; CRICETINAE; MAMMALIA; SUIDAE; SUS SCROFA;

EID: 0023173659     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/326073a0     Document Type: Article

References (29)

1. Dixon, R. A. F. et al. Nature 321, 75-79 (1986).
2. Kobilka, B. K. et al. Proc. natn. Acad. Sci. U.S.A. 84, 46-50 (1987).
3. Yarden, Y. et al Proc. natn. Acad. Sci. U.S.A. 83, 6795-6799 (1986).
4. Kubo, T. et al. Nature 323, 411-416 (1986).
5. Nathans, J. & Hogness, D. S. Cell 34, 807-814 (1983).
6. Lefkowitz, R. J., Stadel, J. M. & Caron, M. G. A. Rev. Biochem. 52, 159-186 (1983).
7. Haga, K., Haga, T. & Ichiyama, A. J. biol. Chem. 261, 10133-10140 (1986).
8. Stryer, L. Cold Spring Harb. Symp. quant. Biol. 48, 841-852 (1983).
9. Gluzman, Y. Cell 23, 175-182 (1981).
10. Benovic, J. L., Shorr, R. G. L., Caron, M. G. & Lefkowitz, R. J. Biochemistry 23, 4510-4518 (1984).
11. Kit, S., Dubbs, D. R., Piekarski, L. J. & Hsu, T. C. Expl Cell Res. 31, 297-312 (1963).
12. Stemweis, P. C. & Gilman, A. G. Proc. natn. Acad. Sci. U.S.A. 79, 4888-4891 (1982).
13. Kent, R. S., DeLean, A. & Lefkowitz, R. J. Molec. Pharmacol. 17, 14-23 (1980).
14. Gilman, A. G. Cell 36, 577-479 (1984).
15. Bar-Sinai, A., Aldouby, Y., Chorev, M. & Levitsky, A. EMBO J. 5, 1175-1180 (1986).
16. Thomas, D. D. & Stryer, L. J. molec. Biol. 154, 145-157 (1982).
17. Scatchard, G. Ann. N.Y. Acad. Sci. 51, 660-672 (1949).
18. Munson, P. J. & Rodard, D. Ann. Biochem. 107, 220-239 (1980).
19. Hargrave, P. A. et al. Vision Res. 24, 1487-1499 (1984).
20. Gibbs, J. B., Sigal, I. S., Poe, M. & Scolnick, E. M. Proc. natn. Acad. Sci. U.S.A. 81, 5704-5708 (1984).
21. Hattori, M. & Sakaki, Y. Ann. Biochem. 152, 232-238 (1986).
22. Okayama, H. & Berg, P. Molec. cell Biol. 3, 280-289 (1983).
23. Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning; a Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).
24. Gorman, C. DNA Cloning, a Practical Approach, Vol. 2, 143-190 (IRL Press, Oxford, 1985).
25. Caron, M. C. & Leflcowitz, R. J. J. biol. Chem. 251, 2374-2384 (1976).
26. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randoll, R. J. J. biol. Chem. 193, 265-275 (1951).
27. Gorman, C., Padmanabhan, R. & Howard, B. Science 221, 551-554 (1983).
28. Southern, P. J. & Berg, P. Molec appl. Genet. 1, 327-338 (1982).
29. Salomon, Y., Landos, C. & Rodbell, M. Analyt. Biochem. 58, 541-548 (1974).