Increase in pO2 and Radiosensitivity of Tumors by Fluosol-DA (20%) and Carbogen

Cancer Research

Volumn 47, Issue 2, 1987, Pages 442-446

  Lee, Intae ^b   Hasegawa, Takeo ^b   Levitt, Seymour H ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOGEN; CARBON DIOXIDE; FLUOROCARBON; FLUOSOL DA; FLUOSOL-DA; OXYGEN; RADIATION SENSITIZING AGENTS; RADIOSENSITIZING AGENT; PERFLUORO COMPOUND;

ANIMAL; ARTICLE; DRUG COMBINATION; EXPERIMENTAL NEOPLASM; METABOLISM; MOUSE; MULTIMODALITY CANCER THERAPY; RADIATION EXPOSURE; SKIN; X RAY; ANIMAL EXPERIMENT; CANCER CHEMOTHERAPY; DRUG DOSE; DRUG EFFICACY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; OXYGEN SUPPLY; PRIORITY JOURNAL; RADIOSENSITIVITY; THERAPY;

ANIMAL; CARBON DIOXIDE; COMBINED MODALITY THERAPY; DRUG COMBINATIONS; FLUOROCARBONS; MICE; NEOPLASMS, EXPERIMENTAL; OXYGEN; RADIATION-SENSITIZING AGENTS; SKIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; X-RAYS;

EID: 0023164712     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Churchill-Davidson, I., Sanger, C., and Thomlinson, R. H. High pressure oxygen and radiotherapy. Lancet, 1: 1091, 1955.
2. Henk, J. M. Does hyperbaric oxygen have a future in radiation therapy? Int. J. Radiat. Oncol. Biol. Phys., 7: 1125-1128, 1981.
3. Dische, S. Hyperbaric oxygen: The Medical Research Council trials and their clinical significance. Br. J. Radiol., 51: 888-894, 1979.
4. Suit, D. H. Modification of radiation exposure. Int. J. Radiat. Oncol. Biol. Phys., 10: 101-108, 1984.
5. Griffin, T. W., Laramore, G. E., Hussey, D. H., Hendrickson, F. R., and Rodriguez-Antunez, A. Fast neutron beam radiation therapy in the United States. Int. J. Radiat. Oncol. Biol. Phys., 8: 2165-2168, 1982.
6. Richter, M. P., and Kligerman, M. M. Particle-beam radiation therapy. 1983 evaluation and recommendations. Cancer Treat. Res., 68: 303-308, 1984.
7. Phillips, T. L., Wasserman, T. H., and Brady, L. W. Clinical trials of hypoxic cell sensitizers. Int. J. Radiat. Oncol. Biol. Phys., 8: 327-333, 1982.
8. Dische, S., Saunders, M. I., Anderson, P., Stratford, M. R., and Minchinton, A. Clinical experience with nitroimidazoles as radiosensitizers. Int. J. Radiat. Oncol. Biol. Phys., 8: 335-338, 1982.
9. Song, C. W., Lee, C. K. K., Rhee, J. G., and Levitt, S. H. Comparison of the cytotoxicity of 5-thio-D-glucose and misonidazole on hypoxic cells in vitro. Int. J. Radiat. Oncol. Biol. Phys., 8: 749-752, 1982.
10. Fischer, J., Rockwell, S., and Martin, D. F. Perfluorochemicals and hyperbaric oxygen in radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 12: 95-102, 1986.
11. Teicher, B. A., and Rose, C. M. Perfluorochemical emulsion can increase tumor radiosensitivity. Science (Wash. DC), 223: 934-936, 1984.
12. Teicher, B. A., and Rose, C. M. Oxygen-carrying perfluorochemical emulsion as an adjuvant to radiation therapy in mice. Cancer Res., 44: 4285–4288, 1984.
13. Rockwell, S. Use of a perfluorochemical emulsion to improve oxygenation in a solid tumor. Int. J. Radiat. Oncol. Biol. Phys., 11: 97-103, 1985.
14. Rockwell, S., Mate, T. P., Irvin, C. G., and Nierenburg, M. Reactions of tumors and normal tissues in mice to irradiation in the presence and absence of a perfluorochemical emulsion. Presented at the Conference on Chemical Modifiers on Cancer Treatment, Abstract No. 4–16, Clearwater, FL, October 20-24, 1985.
15. Zhang, W. L., Pence, D., Patten, M., Levitt, S. H., and Song, C. W. Enhancement of tumor response to radiation by Fluosol-DA (Abstract). Int. J. Radiat. Oncol. Biol. Phys., 10: 172, 1984.
16. Song, C. W., Lee, I., Zhang, W. L., Pence, D. M., and Levitt, S. H. Radiosensitization of mouse tumor by perfluorochemicals and carbogen. Presented at the Conference on Chemical Modifiers of Cancer Treatment, Abstract No. 4–11, Clearwater, FL, October 20–24, 1985.
17. Song, C. W., Zhang, W. L., Pence, D. M., Lee, I., and Levitt, S. H. Increased radiosensitivity by perfluorochemicals and carbogen. Int. J. Radiat. Oncol. Biol. Phys., 11: 1833-1836, 1985.
18. Rose, C., Teicher, B., McIntosh, N., and Lustig, R. A clinical trial of Fluosol-DA in advanced head neck cancer. Presented at the Conference on Chemical Modifiers of Cancer Treatment, Abstract No. 4–19, Clearwater, FL, October 20-24, 1985.
19. Teicher, B. A., McIntosh, N. L., and Rose, C. M. Evidence for an immune component in the enhancement of tumor growth delay with X-ray/Fluosol-DA/oxygen breathing combination therapy. Presented at the 33rd Annual Meeting of the Radiation Research Society, Abstract No. Ji-10, Los Angeles, CA, May 5-9, 1985.
20. Twentyman, P. R., Brown, J. M., Gray, J. W., Franko, A. J., Scoles, M. A., and Kallman, R. F. A new mouse tumor model system (RIF-1) for comparison of endpoint studies. J. Natl. Cancer Inst., 64: 595-604, 1980.
21. Song, C. W., Patten, M. S., Rhee, J. G., Schuman, V. L., and Levitt, S. H. Role of blood flow in the response of RIF-1 tumors to combined treatment of hyperthermia and radiotherapy. In: J. Overgaard (ed.), Hyperthermic Oncology 1984, pp. 292–296. London: Taylor & Francis Ltd., 1984.
22. Naito, R., and Yokoyama, J. Perfluorochemical blood substitutes. “Fluosol-43, Fluosol-DA, 20% and 35%”. Technical Information Series No. 5, The Green Cross Corporation, Osaka, Japan, 1978.
23. Naito, R., and Yokoyama, K. Supplement to perfluorochemical blood substitutes. FC-43 emulsion, Fluosol-DA, 20% and 25%. Technical Information Series No. 7, The Green Cross Corporation, Osaka, Japan, 1981.
24. Schuman, V. L., Levitt, S. H., and Song, C. W. The radioprotective effect of 5-thio-D-glucose on normal tissues in vivo. Int. J. Radiat. Oncol. Biol. Phys., 8: 589-591, 1982.
25. Whalen, W. J., Rilley, J., and Nair, P. A microelectrode for measuring intracellular pO2. J. Appl. Physiol., 23: 798-801, 1967.
26. Schneiderman, G., and Goldstick, T. K. Oxygen electrode design criteria and performance characteristics: recessed cathode. J. Appl. Physiol., 45: 145-154,1978.
27. Brown, J. M., Yu, N. Y., Cory, M. J., Bicknell, R. B., and Taylor, D. L. In vivo evaluation of the radiosensitizing and cytotoxic properties of newly synthesized electron-affinic drugs. Br. J. Cancer, 37 (Supplement 3): 206–211, 1978.
28. Milne, N., Hill, R. P., and Bush, R. S. Factors affecting hypoxic KHT tumor cells in mice breathing O2, O2 + CO2or hyperbaric oxygen with or without anesthesia. Radiology, 106: 663-671, 1973.
29. Kruuv, J. A., Inch, W. R., and McCredie, J. A. Blood flow and oxygenation of tumors in mice. I. Effects of breathing gases containing carbon dioxide at atmospheric pressure. Cancer (Phila)., 20: 51-59, 1967.
30. Kruuv, J. A., Inch, W. R., and McCredie, J. A. Blood flow and oxygenation of tumors in mice. II. Effects of vasodilators. Cancer (Phila)., 20: 60–65, 1967.
31. Kruuv, J. A., Inch, W. R., and McCredie, J. A. Blood flow and oxygenation of tumors in mice. III. Effects of breathing amyl nitrite in oxygen on radiosensitivity of C3H tumor. Cancer (Phila.), 20: 66-70, 1967.