The effect of circulating growth hormone-binding protein on metabolic clearance, distribution, and degradation of human growth hormone

Journal of Clinical Endocrinology and Metabolism

Volumn 64, Issue 4, 1987, Pages 657-660

  Baumann, Gerhard ^a   Amburn, Klaus D ^a   Buchanan, Thomas A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; PROTEIN; RADIOISOTOPE;

ANIMAL EXPERIMENT; BLOOD AND HEMOPOIETIC SYSTEM; DEGRADATION; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ISOLATION; DRUG METABOLISM; DRUG MONITORING; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; NORMAL HUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ANIMAL; CARRIER PROTEINS; GROWTH HORMONE; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0023150078     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-64-4-657     Document Type: Article

References (23)

1. Baumann G, Stolar M, Amburn K, Barsario CP, DeVries BC 1986. A specific growth hormone-binding protein in human plasma: Initial characterization. J Clin Endocrinol Metab 62:134
2. Baumanp G, Amburn K 1986 Human growth hormone circulates in large part as a complex associated with (a) plasma protein(s). Clin Res 34:681A (Abstract).
3. Herington AC, Yiner S, Stevenson J 1986 Identification and characterization of specific binding proteins for growth hormone in normal human sera. J Clin Invest 77:1817
4. Baumann G, Stolar MW, Buchanan TA 1985 Slow metabolic clearance rate of the 20, 000 dalton variant of human growth hormone: Implications for biological activity. Endocrinology 117:1309
5. Baumann G, Stolar MW, Buchanan TA 1986 The metabolic clearance, distribution and degradation of dimeric and monomeric growth hormone: implications for the pattern of circulating growth hormone forms. Endocrinology 119:1497
6. Berman M, Weiss MF 1967 User’s Manual for SAAM. NIH PHS publication 1703. US Government Printing Office, Washington DC
7. Refetoff S, Sônksen P 1970 Disappearance rate of endogenous and exogenous human growth hormone in man. J Clin Endocrinol Metab 30:386
8. Owens D, Srivastava MC, Tomkins CV, Nabarro JDN, Sônksen PH 1973 Studies on the metabolic clearance rate, apparent distribution space and plasma half-disappearance time of unlabelled human growth hormone in normal subjects and in patients with liver disease, renal disease, thyroid disease and diabetes mellitus. Eur J Clin Invest 3:254
9. Parker ML, Utigér RD, Daughaday WH 1962 Studies on human growth hormone. II. The physiological disposition and metabolic fate of human growth hormone in man. J Clin Invest 41:262
10. Navalesi R, Pilo A, Vigneri R 1975 Growth hormone kinetics in diabetic patients. Diabetes 24:317
11. Van Dyke DC, Simpson ME, Li CH, Evans HM 1950 Survival in the circulation of the growth and adrenocorticotrophic hormones as evidenced by parabiosis. Am J Phys 163:297
12. Gemzell CA, Heikenskjôld F, Strôm L 1955 Rate of disappearance of growth hormone from the plasma of rats after a single intravenous injection. Acta Endocrinol (Copenh) 19:181
13. Johnson V, Maack T 1977 Renal extraction, filtration, absorption, and catabolism of growth hormone. Am J Physiol 233:F185
14. 125I in the mouse, Horm Metab Res 5:172
15. Maack T, Johnson V, Kau ST, Figueiredo J, Sigulem D 1979 Renal filtration, transport, and metabolism of low-molecular-weight proteins: à review. Kidney Int 16:251.
16. Sonenberg M, Money WL, Dorans L, Bourque L 1954 The distribution of radioactivity in the tissues of the rat after the administration of radioactive growth hormone preparations. Endocrinology 55:709
17. McCormick JR, Sônksen PH, Soeldner JS, Egdahl RH 1969 Renal handling of insulin and growth hormone in hemorrhagic shock. Surgery 66:175
18. Cameron DP, Burger HG, Catt KJ, Gordon E, Watts JM 1972 Metabolic clearance of human growth hormone in patients with hepatic and renal failure, and in the isolated perfused pig liver. Metabolism 21:895
19. Bratusch-Marrain P, Bjôrkman O, Waldhàusl W, Wahren J 1979 Hepatic disposal of endogenous growth hormone and prolactin in man. Eur J Clin Invest 9:257
20. Taylor AL, Lipman RL, Sàlam A, Mintz DH 1972 Hepatic clearance of human growth hormone. J Clin Endocrinol Metab 34:395
21. Hizukà N, Gorden P, Lësniak MA, Van Obberghen E, Carpentier J-L, Orci L 1981 Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. J Biol Chem 256:4591.
22. Cohen KL, Nissley SP 1976 The serum half-life of somatomedin activity; evidence for growth hormone dependence. Acta Endocrinol (Copenh) 83:243
23. Daughaday WH, Ward AP, Goldberg AC, Trivedi B, Kapadia M 1982 Characterization of somatomedin binding in human serum by ultrafiltration and gel filtration. J Clin Endocrinol Metab 55:916