Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

Journal of Experimental Medicine

Volumn 165, Issue 2, 1987, Pages 302-319

  Jenkins, Marc K ^a   Schwartz, Ronald H ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C;

ANIMAL CELL; ANTIGEN PRESENTATION; CLONE; IMMUNE RESPONSE; IN VITRO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PIGEON; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMAL; ANTIGENS; CARBODIIMIDES; CLONE CELLS; CROSS-LINKING REAGENTS; CYTOCHROME C; ETHYLDIMETHYLAMINOPROPYL CARBODIIMIDE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE TOLERANCE; KINETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; PIGEONS; SPLEEN; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0023143676     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.165.2.302     Document Type: Article

References (51)

1. Oki, A., and E. Sercarz. 1985. T cell tolerance studied at the level of antigenic determinants. I. Latent reactivity to lysozyme peptides that lack suppressogenic epitopes can be revealed in lysozyme-tolerant mice. J Exp. Med. 161: 897.
2. Germain, R. N., and B. Benacerraf. 1981. A single major pathway of T lymphocyte interactions in antigen-specific immune suppression. Scand.J. Immunol. 13: 1.
3. Claman, H. N., S. D. Miller, P. J. Conlon, and J. W. Moorhead. 1980. Control of experimental contact sensitivity. Adv. Immunol. 30: 121.
4. Monroe, J. G., A. Lowy, R. D. Granstein, and M. I. Greene. 1984. Studies of immune responsiveness and unresponsiveness to the p-azobenzenearsonate (ABA) hapten. Immunol. Rev. 80: 103.
5. Borel, Y. 1980. Haptens bound to self IgG induce immunologic tolerance, while when coupled to syngeneic spleen cells they induce immune suppression. Immunol. Rev. 50: 71.
6. Nossal, G. J. V. 1983. Cellular mechanisms of immunologic tolerance. Annu. Rev. Immunol. 1: 33.
7. Taniguchi, M., and J. F. A. P. Miller. 1977. Enrichment of specific suppressor T cells and characterization of their surface markers. J Exp. Med. 146: 1450.
8. Goodman, J. W., and E. E. Sercarz. 1983. The complexity of structures involved in T-cell activation. Annu. Rev. Immunol. 1: 465.
9. − T suppressor cells inhibit the major histocompatibility complex-restricted interaction of T helpers with B cells and/or accessory cells. J. Exp. Med. 158: 1178.
10. Jenkins, M. K., and S. D. Miller. 1985. Immunoregulatory pathways in adult responder mice. III. Establishment of a GAT-specific suppressor T cell clone from GAT-tolerant responders which afferently regulates DTH responses. J Mol. Cell. Immunol. 2: 1.
11. Lamb, J. R., B. J. Skidmore, N. Green, J. M. Chiller, and M. Feldmann. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157: 1434.
12. Lamb, J. R., and M. Feldmann. 1984. Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction. Nature (Lond.). 308: 72.
13. Miller, S. D., R. P. Wetzig, and H. N. Claman. 1979. The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells. J Exp. Med. 149: 758.
14. Brautigen, D. L., S. Ferguson-Miller, and E. Margoliash. 1978. Mitochondrial cytochrome c: preparation and activity of native and chemically modified cytochromes c. Methods Enzymol. 53: 128.
15. Corradin, G., and H. A. Harbury. 1970. Cleavage of cytochrome c with cyanogen bromide. Biochim. Biophys. Acta. 221: 489.
16. Schwartz, R. H., B. S. Fox, E. Fraga, C. Chen, and B. Singh. 1985. The T lymphocyte response to cytochrome c. V. Determination of the minimal peptide size required for stimulation of T cell clones and assessment of the contribution of each residue beyond this size to antigenic potency. J Immunol. 135: 2598.
17. Julius, M. H., E. Simpson, and L. A. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3: 465.
18. Ozato, K., N. Mayer, and D. H. Sachs. 1980. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and la antigens. J Immunol. 124: 533.
19. Oi, V. T., P. P. Jones, J. W. Coding, and L. A. Herzenberg. 1978. Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and la antigens. Curr. Top. Microbiol. Immunol. 81: 115.
20. McGrath, M. S., E. Pillemer, and I. L. Weissman. 1980. Murine leukemogenesis: monoclonal antibodies to T cell determinants arrest T-lymphoma cell proliferation. Nature (Lond.). 285: 259.
21. Ledbetter, J. A., and L. A. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47: 63.
22. Lanier, L. L., G. A. Gutman, D. E. Lewis, S. T. Griswold, and N. L. Warner. 1982. Monoclonal antibodies against rat immunoglobulin kappa chains. Hybridoma. 1: 125.
23. Matis, L. A., D. L. Longo, S. M. Hedrick, C. Hannum, E. Margoliash, and R. H. Schwartz. 1983. Clonal analysis of the major histocompatibility complex-restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome c. J. Immunol. 130: 1527.
24. Ashwell, J. D., B. S. Fox, and R. H. Schwartz. 1986. Functional analysis of the interaction of the antigen-specific T cell receptor with its ligands. J Immunol. 136: 757.
25. Suzuki, G., and R. H. Schwartz. 1986. The pigeon cytochrome c-specific T cell response of low responder mice. I. Identification of antigenic determinants on fragment 1-65. J. Immunol. 136: 230.
26. Kimoto, M., and C. G. Fathman. 1981. Antigen-reactive T cell clones. I. Transcom-plementing hybrid I-A region gene products function effectively in antigen presentation. J. Exp. Med. 152: 759.
27. Ashwell, J. D., C. Chen, and R. H. Schwartz. 1986. High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules. J Immunol. 136: 389.
28. Bhattacharya, A., M. E. Dorf, and T. A. Springer. 1981. A shared alloantigenic determinant on la antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol. 127: 2488.
29. Schwartz, R. H. 1985. T-Lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3: 237.
30. Quill, H., L. Carlson, B. S. Fox, J. Weinstein, and K. H. Schwartz. 1986. Optimization of antigen presentation to T cell hybridomas by purified la molecules in planar membranes. Ia molecule polymorphism determines the antigenic fine specificity of the response to cytochrome c peptides. J Immunol. Methods. In press.
31. Miller, S. D., M. S. Sy, and H. N. Claman. 1977. The induction of hapten-specific T cell tolerance using hapten-modified lymphoid cells. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state. Eur. J. Immunol. 7: 165.
32. Solinger, A. M., M. E. Ultee, E. Margoliash, and R. H. Schwartz. 1979. T lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes. J Exp. Med. 150: 830.
33. Schwartz, R. H., and W. E. Paul. 1976. T-Lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation. J Exp. Med. 143: 529.
34. Gammon, G., K. Dunn, N. Shastri, A. Oki, S. Wilbur, and E. E. Sercarz. 1986. Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature (Lond.). 319: 413.
35. Groves, E. S., and A. Singer. 1983. Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens. J Exp. Med. 158: 1483.
36. Matzinger, P., R. Zamoyska, and H. Waldmann. 1984. Self-tolerance is H-2 restricted. Nature (Lond.). 308: 739.
37. Rammensee, H., and M.J. Bevan. 1984. Evidence from in vitro studies that tolerance to self antigens is MHC-restricted. Nature (Lond.). 308: 741.
38. + cells compatible with the recipient. Nature (Lond.). 278: 257.
39. Jenkins, M. K., C. Waltenbaugh, and S. D. Miller. 1985. Immunoregulatory pathways in adult responder mice. II. Regulation of delayed-type hypersensitivity responses by GAT-specific suppressor factors present in GAT-tolerant adult responder mice. J. Immunol. 134: 114.
40. 10 by a specific monoclonal T cell factor. J. Exp. Med. 152: 235.
41. Baxevanis, C. N., N. Ishii, Z. A. Nagy, andj. Klein. 1982. H-2-controlled suppression of T cell response to lactate dehydrogenase B. Characterization of the lactate dehydrogenase B suppressor pathway. J Exp. Med. 156: 822.
42. Reinherz, E. L., S. Meuer, K. A. Fitzgerald, R. E. Hussey, H. Levine, and S. F. Schlossman. 1982. Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell. 30: 735.
43. Weiss, A., R. Wiskocil, and J. Stobo. 1984. The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL-2 production reflects events occurring at a pre-translational level. J Immunol. 133: 1.
44. Otten, G., D. B. Wilde, M. B. Prystowsky, J. S. Olshan, H. Rabin, L. E. Henderson, and F. W. Fitch. 1986. Cloned helper T cells exposed to IL-2 become unresponsive to antigen and concanavalin A but not to calcium ionophore and phorbol ester. Eur. J. Immunol. 16: 217.
45. Bretscher, P., and M. Cohn. 1970. A theory of self-nonself discrimination: paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science (Wash. DC). 169: 1042.
46. Nossal, G. J. V., and B. L. Pike. 1978. Mechanisms of clonal abortion tolerogenesis. I. Response of immature, hapten-specific B lymphocytes. J Exp. Med. 148: 1161.
47. Letvin, N. L., I. Fox, M. I. Greene, B. Benacerraf, and R. N. Germain. 1980. Immunologic effects of whole body ultraviolet (UV) irradiation. II. Defect in splenic adherent cell antigen presentation for stimulation of T cell proliferation. J. Immunol. 125: 1402.
48. Ashwell, J. D., A. L. DeFranco, W. E. Paul, and R. H. Schwartz. 1984. Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp. Med. 159: 881.
49. Lu, C. Y., D. I. Beller, and E. R. Unanue. 1980. A defect in the antigen presenting function of macrophages from neonatal mice. Nature (Lond.). 282: 327.
50. Kyewski, B. A., C. G. Fathman, and R. V. Rouse. 1986. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation. J Exp. Med. 163: 231.
51. Tomonari, K. 1985. T cell receptor expressed on an auto-reactive T-cell clone, clone 4. I. Induction of various T-receptor functions by anti-T idiotypic antibodies. Cell. Immunol. 96: 147.